PACTG 1006: EFFECTS OF HAART ON THE RECOVERY OF IMMUNE FUNCTION IN HIV+ CHILDREN
PACTG 1006: EFFECTS OF HAART ON THE RECOVERY OF IMMUNE FUNCTION IN HIV+ CHILDREN
批准号:
7605689
负责人:
William Borkowsky
金额:
$3.73万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-04-01 至 2008-03-31
关键词:
Antibody FormationAntigensCD4 Lymphocyte CountCD4 Positive T LymphocytesCandidaCell CountChildChildhoodComputer Retrieval of Information on Scientific Projects DatabaseFundingGrantGrowthHIVHepatitis AHepatitis A immunizationHighly Active Antiretroviral TherapyImmuneImmunizationImmunocompromised HostImmunologicsInstitutionMeasuresNatural regenerationNumbersPhenotypePlasmaPopulationPurposeRNARandomizedRecoveryRecovery of FunctionResearchResearch PersonnelResourcesSecondary ImmunizationSeriesSerologicalSourceT-LymphocyteTestingTetanusTetanus ToxoidTetanus VaccineTranslatingUnited States National Institutes of HealthVaccinationagedcell mediated immune responsecomparativefollow-upimmune functionresponsetreatment duration
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This study is a randomized, comparative response study with long-term follow-up in HIV-infected children aged 2-17 years who are severely immunocompromised and are initiating highly active antiretroviral therapy (HAART). Subjects must be virologic responders, defined as >0.75 log decrease in plasma HIV RNA copy number 1 month after initiation of HAART. It will consist of approximately 90 subjects in two groups. The purpose of this study is to assess the ability of newly derived CD4 T cells to spontaneously develop lymphoproliferative responses to a recall antigen, tetanus toxoid, or to develop responses after booster vaccinations with tetanus vaccine; to assess the ability to develop protective antibody responses to a T cell-dependent antigen using a primary series of hepatitis A vaccinations.; and to measure the durability of any response beyond the last vaccination.
The rationale for this study is that HIV-infected children initiating HAART have shown significant inhibition of HIV growth and significant increases in CD4 T cell counts. It is not known to what extent an increase in CD4 count in this population of children translates to a complete functional immune recovery. HIV-infected children have typically demonstrated poor serological responses to routine childhood immunizations. This study will examine the phenotype of T cells regenerated post-HAART initiation and will assess function by evaluating T cell responses to neoantigens and recall antigens. Cell-mediated immune responses to an environmental antigen (Candida), a recall antigen (tetanus), and a primary immunogen (hepatitis A) will be tested. Studies of immunologic function and recovery will be assessed and correlated with CD4 cells, HAART treatment, and duration of response.
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Virology Core
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批准号:8134721
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项目类别:
-
资助金额:$12.77万
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财政年份:2010
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负责人:William Borkowsky
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依托单位:
CLINICAL TRIAL: PACTG 390: ANTIRETROVIRAL REGIMENS AND TREATMENT-SWITCHING STRAT
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批准号:7718416
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项目类别:
-
资助金额:$1.27万
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财政年份:2008
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负责人:William Borkowsky
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依托单位:
CLINICAL TRIAL: PACTG 1020-A: NOVEL PROTEASE INHIBITOR (BMS-232632) IN HIV-INFEC
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批准号:7718391
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项目类别:
-
资助金额:$7.33万
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财政年份:2008
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负责人:William Borkowsky
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依托单位:
CLINICAL TRIAL: PACTG 1025: PERINATAL CORE PROTOCOL (AIDS)
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批准号:7718399
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项目类别:
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资助金额:$20.7万
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财政年份:2008
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负责人:William Borkowsky
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依托单位:
CLINICAL TRIAL: ACTG 219: PEDIATRIC LATE OUTCOMES (AIDS)
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批准号:7718380
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项目类别:
-
资助金额:$0.64万
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财政年份:2008
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负责人:William Borkowsky
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依托单位:
PACTG 390: ANTIRETROVIRAL REGIMENS AND TREATMENT-SWITCHING STRATEGIES (AIDS)
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批准号:7605729
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项目类别:
-
资助金额:$1.1万
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财政年份:2007
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负责人:William Borkowsky
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依托单位:
ACTG 219: PEDIATRIC LATE OUTCOMES (AIDS)
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批准号:7605676
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项目类别:
-
资助金额:$23.92万
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财政年份:2007
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负责人:William Borkowsky
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依托单位:
PACTG 1025: PERINATAL CORE PROTOCOL (AIDS)
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批准号:7605703
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项目类别:
-
资助金额:$24.58万
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财政年份:2007
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负责人:William Borkowsky
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依托单位:
PACTG P1038: LOPINAVIR/RITONAVIR IN PEDIATRIC SUBJECTS WITH HIV PREVIOUSLY TREAT
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批准号:7605739
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项目类别:
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资助金额:$1.1万
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财政年份:2007
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负责人:William Borkowsky
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依托单位:
PACTG 1020-A: NOVEL PROTEASE INHIBITOR (BMS-232632) IN HIV-INFECTED CHILDREN
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批准号:7605692
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项目类别:
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资助金额:$7.9万
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财政年份:2007
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负责人:William Borkowsky
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依托单位:
PACTG P1061S: IMMUNOLOGIC MEMORY AFTER VACCINATION IN HAART-TREATED CHILDREN
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批准号:7605765
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项目类别:
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资助金额:$0.66万
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财政年份:2007
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负责人:William Borkowsky
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依托单位:
PACTG 1020-A: NOVEL PROTEASE INHIBITOR (BMS-232632) IN HIV-INFECTED CHILDREN
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批准号:7378256
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项目类别:
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资助金额:$2.67万
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财政年份:2006
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负责人:William Borkowsky
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依托单位:
PERSISTENCE OF IMMUNE RESPONSE TO VACCINIA IN IMMUNOCOMPETENT AND HIV+ ADULTS
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批准号:7378297
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项目类别:
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资助金额:$0.5万
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财政年份:2006
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负责人:William Borkowsky
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依托单位:
ANTIRETROVIRAL THERAPY ON BODY COMPOSITION IN HIV-INFECTED CHILDREN
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批准号:7378255
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项目类别:
-
资助金额:$0.33万
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财政年份:2006
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负责人:William Borkowsky
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依托单位:
PACTG P1055: PSYCHIATRIC CO-MORBIDITY IN PERINATALLY HIV-INFECTED CHILDREN
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批准号:7378354
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项目类别:
-
资助金额:$0.33万
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财政年份:2006
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负责人:William Borkowsky
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依托单位:
PACTG 1015: INTERRUPTING HAART IN HIV+ CHILDREN W/ LOW VIRAL LOADS
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批准号:7378257
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项目类别:
-
资助金额:$1.0万
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财政年份:2006
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负责人:William Borkowsky
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依托单位:
PACTG 390: ANTIRETROVIRAL REGIMENS AND TREATMENT-SWITCHING STRATEGIES (AIDS)
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批准号:7378314
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项目类别:
-
资助金额:$0.17万
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财政年份:2006
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负责人:William Borkowsky
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依托单位:
PACTG 394: TENOFOVIR DF IN HIV-1 INFECTED PREGNANT WOMEN AND THEIR INFANTS
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批准号:7378332
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项目类别:
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资助金额:$0.84万
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财政年份:2006
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负责人:William Borkowsky
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依托单位:
PACTG P1045: PREVALENCE OF ABNORMALITIES IN VERTICALLY HIV-INFECTED CHILDREN
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批准号:7378304
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项目类别:
-
资助金额:$0.17万
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财政年份:2006
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负责人:William Borkowsky
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依托单位:
PACTG 382: DMP 266 & NELFINAVIR COMBINATION IN HIV-INFECTED CHILDREN (AIDS)
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批准号:7378249
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项目类别:
-
资助金额:$0.5万
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财政年份:2006
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负责人:William Borkowsky
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依托单位:
国内基金
海外基金
Neo-antigens暴露对肾移植术后体液性排斥反应的影响及其机制研究
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批准号:2022J011295
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项目类别:省市级项目
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资助金额:10.0万元
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批准年份:2022
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负责人:王亚伟
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依托单位:
结核分枝杆菌持续感染期抗原(latency antigens)的重组BCG疫苗研究
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批准号:30801055
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项目类别:青年科学基金项目
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资助金额:19.0万元
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批准年份:2008
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负责人:王丽梅
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依托单位: