WOMEN'S HEALTH IN CYSTIC FIBROSIS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。来自明尼苏达大学CF中心患者的数据显示，与男性相比，女性的死亡率更高，这似乎在接近青春期时有所增加。该假说认为雌激素和孕激素可能对慢性萎缩性肺病有负面影响。本研究将在月经周期的滤泡期和黄体期检查患有CFF的年轻女性的肺功能。服用避孕药的CF妇女的肺功能将与未服用避孕药的妇女进行比较。还将获得更年期对肺功能、骨骼健康、血脂水平和心血管疾病影响的试点信息。如果有证据表明激素对肺功能有影响，可能会有未来的治疗意义，并有可能改善患有CF的妇女的存活率。在整个研究过程中，GCRC为患者在抽血、取痰和其他数据收集过程中与患者互动提供了一个理想的位置。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Data from patients seen at the University of Minnesota CF Center demonstrate greater mortality in women compared to men which appears to increase near the time of puberty. The hypothesis is that estrogen and progesterone may have a negative impact on CF lung disease. The present study will examine lung function during the follicular and luteal phases of the menstrual cycle in normally menstruating young women with CF. Lung function of women with CF on birth control pills will be compared to those that are not. Pilot information on the effect of menopause on lung function, bone health, lipid levels and cardiovascular disease will also be obtained. If there is evidence of hormonal influence on pulmonary function, there may be future therapeutic implications and the potential to improve survival in women with CF. The GCRC provides an ideal location to interact with patients during blood draws, sputum collection and other data collection throughout the studies.