WOMEN'S HEALTH IN CYSTIC FIBROSIS

囊性纤维化的女性健康

• 批准号: 7605976
• 负责人: JOANNE L BILLINGS
• 金额: $ 0.79万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605976
• 关键词: Blood; Cardiovascular Diseases; Collection; Computer Retrieval of Information on Scientific Projects Database; Cystic Fibrosis; Data; Data Collection; Estrogens; Funding; Future; Grant; Hormonal; Institution; Lipids; Location; Luteal Phase; Menopause; Minnesota; Oral Contraceptives; Patients; Progesterone; Puberty; Pulmonary Cystic Fibrosis; Research; Research Personnel; Resources; Respiratory physiology; Source; Sputum; Therapeutic; Time; United States National Institutes of Health; Universities; Woman; Women' s Health; bone health; improved; men; mortality; pulmonary function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Data from patients seen at the University of Minnesota CF Center demonstrate greater mortality in women compared to men which appears to increase near the time of puberty. The hypothesis is that estrogen and progesterone may have a negative impact on CF lung disease. The present study will examine lung function during the follicular and luteal phases of the menstrual cycle in normally menstruating young women with CF. Lung function of women with CF on birth control pills will be compared to those that are not. Pilot information on the effect of menopause on lung function, bone health, lipid levels and cardiovascular disease will also be obtained. If there is evidence of hormonal influence on pulmonary function, there may be future therapeutic implications and the potential to improve survival in women with CF. The GCRC provides an ideal location to interact with patients during blood draws, sputum collection and other data collection throughout the studies.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 来自明尼苏达大学 CF 中心的患者数据显示，与男性相比，女性死亡率更高，而且在青春期附近似乎有所增加。 假设雌激素和孕激素可能对 CF 肺部疾病产生负面影响。 本研究将检查患有 CF 的正常月经年轻女性在月经周期的卵泡期和黄体期的肺功能。 服用避孕药的 CF 女性的肺功能将与未服用避孕药的女性进行比较。 还将获得有关更年期对肺功能、骨骼健康、血脂水平和心血管疾病影响的初步信息。 如果有证据表明激素对肺功能有影响，则可能会对未来的治疗产生影响，并有可能提高患有 CF 的女性的生存率。 GCRC 提供了在整个研究过程中进行抽血、痰液收集和其他数据收集期间与患者互动的理想场所。