LOW DOSE INHALED NITRIC OXIDE FOR PREVENTION AND TREATMENT OF CHRONIC LUNG

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。一氧化氮是一种天然气体，通常在肺部产生，它打开了通往肺部的血管。在患有其他类型影响肺部血流的疾病的成人和婴儿中，已经研究了呼吸少量一氧化氮气体的效果。到目前为止所做的测试表明，一氧化氮可以使血液更容易流向肺部，并可以改善血液流向肺部最健康的部位。一氧化氮已被用于少数严重CLD早产儿使用呼吸机。到目前为止，一些接受一氧化氮治疗的CLD婴儿已经证明他们所需的氧气量减少，并且随着时间的推移，他们已经能够耐受较低的呼吸机设置。重要的是要理解，高呼吸机压力和高氧气是已知的肺损伤的原因。本研究的目的是确定在出生后2周仍需要使用呼吸机的早产儿如果通过呼吸机接受少量一氧化氮，是否不太可能发展为CLD。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nitric oxide is a natural gas ordinarily produced in the lung, which opens the blood vessels going to the lungs. The effect of breathing small amounts of nitric oxide gas has been studied in adults and infants with other types of diseases affecting blood flow to the lungs. The tests done so far suggest that nitric oxide can make it easier for blood to flow to the lungs and can improve blood flow to the healthiest parts of the lung. Nitric oxide has been used in a small number of premature infants with severe CLD who are on ventilators. Some infants with CLD who have received nitric oxide so far have demonstrated a decrease in the amount of oxygen that they require, and over time they have been able to tolerate lower ventilator settings. It is important to understand that high ventilator pressures and high oxygen are known to contribute to lung injury. The purpose of this study is to determine whether premature babies who still need to be on the ventilator at 2 weeks of life will be less likely to develop CLD if they receive a small amount of nitric oxide through the ventilator.