PAROXETINE EFFECTS ON RESPONSE TO MENTAL STRESS IN PATIENTS WITH STABLE ANGINA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This double-blind crossover placebo controlled crossover study is assessing the effect of 1 month of paroxetine administration on cardiovascular response and psychological discomfort during 2 mental stress tasks in patients with stable angina or a history of angina. After a screening visit, subjects are randomized to receive one month of treatment with either paroxetine (10mg/day for 1 week followed by 20 mg/day) or placebo after which they return to the GCRC for "mental stress testing." Cardiovascular response is measured while subjects perform two tasks expected to result in some mental stress. These tasks consist of giving a short speech and performing a mental arithmetic task. Starting one-half hour prior to mental stress testing and continuing until the conclusion of the visit, blood pressure and heart rate are measured at 1 to 2 minute intervals via an automated blood pressure measuring device. Blood (20 cc's) is drawn immediately prior to mental stress testing (at the end of the relaxation phase) and during each mental stress task. Psychological discomfort during the procedure is assessed after mental stress testing is complete. For the following month, subjects receive the alternate treatment after which "mental stress testing" is repeated.