PAROXETINE EFFECT ON RESPONSE TO MENTAL STRESS DURING CIGARETTE SMOKING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究旨在评估帕罗西汀治疗1个月对吸烟者吸烟后即刻在两种心理应激任务中的心血管反应和主观不适的影响。每个受试者接受一个月的帕罗西汀或安慰剂治疗，之后他们返回GCRC进行访问，在此期间测量心血管反应，同时执行两项预计会导致一些精神压力的任务。这些任务包括发表简短的演讲和执行心算任务。在接下来的一个月里，受试者接受替代治疗，之后再次测量对压力任务的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is assessing the effect of 1 month of paroxetine treatment on cardiovascular response and subjective discomfort during 2 mental stress tasks in smokers immediately after smoking a cigarette. Each subject receives one month of either paroxetine or placebo after which they return to the GCRC for a visit during which cardiovascular response is measured while performing two tasks expected to result in some mental stress. These tasks consist of giving a short speech and performing a mental arithmetic task. For the following month, subjects receive the alternate treatment after which response to the stress tasks is measured again.