EFFECTS OF AGE ON LIMB ARTERIAL COMPLIANCE

年龄对四肢动脉顺应性的影响

• 批准号: 7378546
• 负责人: DAVID N PROCTOR
• 金额: $ 0.86万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378546
• 关键词: EFFECTS; AGE; LIMB; ARTERIAL; COMPLIANCE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many different types of changes in the vascular system may be at the heart of decreased blood vessel function with aging in humans. A key factor in this decrement in function appears to be changes in mechanical properties of the vessel walls and how they respond to blood pressure changes. Compliance of blood vessels is their distensibility in response to pressure changes inside them, i.e. how much the vessel walls move every time the heart beats. We have developed a software that can simultaneously record blood pressure tracings from a noninvasive blood pressure monitor and changes in calf volume from a noninvasive surface strain gauge every time the heart beats to derive whole calf compliance. This project will combine this technology with the method generally used to assess single vessel compliance using Doppler ultrasound and noninvasive blood pressure monitoring to compare whole calf compliance with that of the major artery feeding the calf vascular bed, the popliteal artery. This will be done to compare age-related changes in vessel compliance (from Doppler imaging and blood pressure tracings) with age-related changes in whole limb compliance (from surface strain gauge and blood pressure tracings) which reflects changes in the large vessels in the limb and the small vasculature that cannot be easily studied on its own. Measurements will be made during rest and moderate heating (about the temperature of a common sauna) of one calf and foot only to induce a locally higher blood flow without causing any cardiovascular distress or discomfort.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。血管系统中许多不同类型的变化可能是人类血管功能随年龄增长而下降的核心。这种功能下降的一个关键因素似乎是血管壁机械性能的变化以及它们对血压变化的反应。血管的顺应性是它们响应于内部压力变化的扩张性，即每次心脏跳动时血管壁移动多少。我们已经开发了一种软件，可以同时记录血压描记从一个无创血压监测仪和变化的小腿体积从一个无创表面应变计每次心脏跳动，以获得整个小腿顺应性。本项目将联合收割机与通常用于评估单血管顺应性的方法结合使用多普勒超声和无创血压监测，以比较整个小腿与小腿血管床主要动脉（腘动脉）的顺应性。这样做的目的是比较血管顺应性的年龄相关变化（来自多普勒成像和血压描记）与整个肢体顺应性的年龄相关变化（来自表面应变仪和血压描记），这反映了肢体中大血管和小血管系统的变化，这些变化本身无法轻易研究。将在休息和适度加热（约为普通桑拿浴的温度）时对一只小腿和足部进行测量，仅用于诱导局部较高的血流量，而不会引起任何心血管不适或不适。