INFLUENCE OF FITNESS ON LEG HEMODYNAMIC RESPONSES IN AGING WOMEN AND MEN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是比较腿部血流和血管传导性的反应，以次最大动态运动的老年人之间的健身和活动水平的广泛范围。我们假设：a）健身水平将对分级运动的血流动力学反应产生调节性影响，因此与不太健康的老年男性相比，更健康的老年男性的腿部血流量将更高。其次，我们假设a）在相对“正常”范围内的健身不会对老年女性次极量运动的充血反应产生调节性影响，以及B）与年轻女性相比，具有最高健身水平的老年女性将显示出对运动的血流反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main purpose of this study is to compare leg blood flow and vascular conductance responses to submaximal dynamic exercise between older individuals over a broad range of fitness and activity levels. We hypothesize that a) fitness level will have a modulatory influence on the hemodynamic response to graded exercise such that leg blood flow will be higher in more fit older men as compared to less fit older men. Secondly, we hypothesize that a) fitness across a relatively "normal" range will not have a modulatory influence on the hyperemic response to submaximal exercise in older women, and b) older women with the highest fitness levels will show preserved blood flow responses to exercise as compared to young women.