INFLUENCE OF FITNESS ON LEG HEMODYNAMIC RESPONSES IN AGING WOMEN AND MEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的主要目的是比较不同健身和活动水平的老年人对次极量动态运动的腿部血流和血管传导性的反应。我们假设，a)健康水平将对分级运动的血液动力学反应产生调制影响，因此，与不太健康的老年男性相比，更健康的老年男性的腿部血流量会更高。其次，我们假设a)相对“正常”范围内的健康状况不会对老年女性对次极量运动的充血反应产生调节性影响，b)与年轻女性相比，健康水平最高的老年女性对运动的血流反应将保持不变。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main purpose of this study is to compare leg blood flow and vascular conductance responses to submaximal dynamic exercise between older individuals over a broad range of fitness and activity levels. We hypothesize that a) fitness level will have a modulatory influence on the hemodynamic response to graded exercise such that leg blood flow will be higher in more fit older men as compared to less fit older men. Secondly, we hypothesize that a) fitness across a relatively "normal" range will not have a modulatory influence on the hyperemic response to submaximal exercise in older women, and b) older women with the highest fitness levels will show preserved blood flow responses to exercise as compared to young women.