ATN 021: PREVALENCE OF MORPHOLOGIC AND METABOLIC ABNORMALITIES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项横断面调查，旨在评估艾滋病毒感染女性青年的形态和代谢异常的患病率和严重程度，并评估与这些异常相关的药物和非药物因素。本研究旨在评估感染HIV和未感染HIV的年轻女性在葡萄糖代谢、脂质、乳酸、身体成分和骨密度方面是否存在显著差异。此外，本研究将评估暴露于特定类别的抗逆转录病毒（ARV）药物是否以不同的方式与HIV感染者的代谢和形态异常相关。该研究包括一次性收集病史数据、实验室标本和身体评估。这项研究将阐明需要进一步深入研究以了解蛋白酶抑制剂（PI）和非核苷类似物逆转录酶抑制剂（NNRTI）为基础的治疗在年轻女性中的病理生理作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a cross-sectional survey designed to evaluate the prevalence and severity of morphologic and metabolic abnormalities in HIV infected female youth and to assess the drug and non-drug factors related to these abnormalities. This study is designed to assess whether there exist significant differences in glucose metabolism, lipids, lactate, body composition and bone density between HIV infected and uninfected young women. Furthermore, this study will evaluate whether exposure to specific classes of antiretroviral (ARV) medications is associated with the metabolic and morphologic abnormalities among HIV infected individuals in different ways. The study involves a one-time collection of medical history data, laboratory specimens, and physical assessments. This study will elucidate the need for further in-depth study to understand the pathophysiological effects of protease inhibitor (PI)- and non-nucleoside analogue reverse transcriptase inhibitor (NNRTI)-based therapies in young females.