ATN 021B: PREVALENCE OF MORPHOLOGIC AND METABOLIC ABNORMALITIES IN HIV-INFEC

ATN 021B：HIV 感染者形态和代谢异常的患病率

• 批准号: 7608165
• 负责人: Ligia Peralta
• 金额: $ 0.73万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608165
• 关键词: Age; Anti-Retroviral Agents; Caring; Computer Retrieval of Information on Scientific Projects Database; Cross-Sectional Studies; Dyslipidemias; Enrollment; Fatty acid glycerol esters; Funding; Glucose; Grant; HIV; HIV Infections; HIV Seropositivity; Highly Active Antiretroviral Therapy; Institution; Insulin Resistance; Life Expectancy; Metabolic; Osteoporosis; Patients; Pharmaceutical Preparations; Prevalence; Prevalence Study; Research; Research Personnel; Resources; Risk; Severities; Source; Treatment Protocols; United States National Institutes of Health; Viral; Youth; antiretroviral therapy; base; day; design; lipid metabolism; male; outcome forecast

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is a cross-sectional survey designed to evaluate the prevalence and severity of alterations in fat distribution, glucose, lipid metabolism, and BMD in HIV-infected and -uninfected male youth as well as drug and non-drug factors related to their presence. Despite unarguable advances in HIV care associated with highly active antiretroviral therapy, it is now apparent that many patients on these regimens are developing potentially deleterious metabolic complications, which include insulin resistance, dyslipidemia, alterations in fat distribution, osteopenia, osteoporosis, and, less commonly, hyperlactatemia. Although the long-term risks associated with these complications in patients with HIV infection are unknown, there is mounting concern that they may impact the long-term prognosis in patients whose life expectancies are significantly extended due to effective viral suppression by HAART. In this study, the prevalence of morphological and metabolic abnormalities in HIV-uninfected youth at high risk for HIV infection and HIV-infected youth on different types of antiretroviral medications will be determined. Approximately 250 male youth between the ages of 12 years, 0 days and 24 years, 364 days will be enrolled in four study groups: a group of 50 HIV-negative subjects; a group of 100 HIV-positive subjects who are antiretroviral therapy nanve; and two groups of up to 50 HIV-positive subjects each, one on an NNRTI-based regimen and the other on a PI-based regimen.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究是一项横断面调查，旨在评估HIV感染和未感染的男性青年中脂肪分布、血糖、脂代谢和骨密度改变的患病率和严重程度，以及与其存在相关的药物和非药物因素。尽管与高效抗逆转录病毒治疗相关的艾滋病毒治疗取得了无可争议的进步，但现在很明显，这些方案的许多患者都出现了潜在的有害代谢并发症，包括胰岛素抵抗、血脂异常、脂肪分布变化、骨量减少、骨质疏松症，以及较少见的高乳酸血症。尽管与艾滋病毒感染患者的这些并发症相关的长期风险尚不清楚，但越来越多的人担心，这些并发症可能会影响患者的长期预后，这些患者的预期寿命因HAART的有效病毒抑制而显著延长。在这项研究中，将确定艾滋病毒感染高危未感染艾滋病毒的青年和接受不同类型抗逆转录病毒药物治疗的艾滋病毒感染青年的形态和代谢异常的发生率。大约250名12岁零天至24岁364天的男性青年将参加四个研究组：50名艾滋病毒阴性受试者；100名艾滋病毒阳性受试者接受NVE抗逆转录病毒治疗；以及两组，每组最多50名艾滋病毒阳性受试者，一组接受NNRTI方案，另一组接受PI方案。