ATN 021B: PREVALENCE OF MORPHOLOGIC AND METABOLIC ABNORMALITIES IN HIV-INFEC

ATN 021B：HIV 感染者形态和代谢异常的患病率

• 批准号: 7608165
• 负责人: Ligia Peralta
• 金额: $ 0.73万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608165
• 关键词: Age; Anti-Retroviral Agents; Caring; Computer Retrieval of Information on Scientific Projects Database; Cross-Sectional Studies; Dyslipidemias; Enrollment; Fatty acid glycerol esters; Funding; Glucose; Grant; HIV; HIV Infections; HIV Seropositivity; Highly Active Antiretroviral Therapy; Institution; Insulin Resistance; Life Expectancy; Metabolic; Osteoporosis; Patients; Pharmaceutical Preparations; Prevalence; Prevalence Study; Research; Research Personnel; Resources; Risk; Severities; Source; Treatment Protocols; United States National Institutes of Health; Viral; Youth; antiretroviral therapy; base; day; design; lipid metabolism; male; outcome forecast

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is a cross-sectional survey designed to evaluate the prevalence and severity of alterations in fat distribution, glucose, lipid metabolism, and BMD in HIV-infected and -uninfected male youth as well as drug and non-drug factors related to their presence. Despite unarguable advances in HIV care associated with highly active antiretroviral therapy, it is now apparent that many patients on these regimens are developing potentially deleterious metabolic complications, which include insulin resistance, dyslipidemia, alterations in fat distribution, osteopenia, osteoporosis, and, less commonly, hyperlactatemia. Although the long-term risks associated with these complications in patients with HIV infection are unknown, there is mounting concern that they may impact the long-term prognosis in patients whose life expectancies are significantly extended due to effective viral suppression by HAART. In this study, the prevalence of morphological and metabolic abnormalities in HIV-uninfected youth at high risk for HIV infection and HIV-infected youth on different types of antiretroviral medications will be determined. Approximately 250 male youth between the ages of 12 years, 0 days and 24 years, 364 days will be enrolled in four study groups: a group of 50 HIV-negative subjects; a group of 100 HIV-positive subjects who are antiretroviral therapy nanve; and two groups of up to 50 HIV-positive subjects each, one on an NNRTI-based regimen and the other on a PI-based regimen.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究是一项横断面调查，旨在评估脂肪分布，葡萄糖，脂质代谢和BMD的患病率和严重程度，在受HIV感染和未感染的男性青年以及与存在有关的药物和非药物因素中。尽管与高度活性抗逆转录病毒疗法相关的HIV护理方面的进步不可忽视，但现在很明显，这些方案中的许多患者正在发展潜在的有害代谢并发症，包括胰岛素抵抗，血脂异常，脂肪分布的改变，骨质疗法，骨质骨髓病，骨质疏松症以及常见的超炎，超级胰素性，超级炎症。尽管与HIV感染患者的这些并发症相关的长期风险尚不清楚，但人们一直担心它们可能会影响预期寿命由于HAART有效抑制病毒而显着延长的患者的长期预后。在这项研究中，将确定因艾滋病毒感染而高风险的艾滋病毒未感染的年轻人的形态和代谢异常的患病率，并在不同类型的抗逆转录病毒药物上受到了艾滋病毒感染的高风险。在12岁，0天和24岁之间，大约250名男性年轻人将参加四个研究小组：一组50名HIV阴性受试者；一组抗逆转录病毒疗法的100名HIV阳性受试者；以及两组最多50个HIV阳性受试者，一组是基于NNRTI的方案，另一组是基于PI的方案。