Adolescent Trials Network for HIV/AIDS Interventions

青少年艾滋病毒/艾滋病干预试验网络

• 批准号: 7196463
• 负责人: Ligia Peralta
• 金额: $ 35.01万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-16 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7196463
• 关键词: AIDS/HIV problem; Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; Adult; Age; Area; Baltimore; Basic Science; Caring; Childhood; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Outreach; Counseling; Databases; Early identification; Environment; Goals; HIV; Heterosexuals; Human Virology; Immunology; Institutes; Intervention; Laboratories; Leadership; Maryland; Minority; Mission; Modeling; Patients; Population; Protocols documentation; Research; Research Personnel; Risk; Scientist; Services; Site; Structure; Student Dropouts; Testing; Time; Universities; Youth; adolescent substance abuse; base; collaborative trial; ethnic minority population; experience; medical specialties; member; outreach program; performance site; programs; quality assurance; tertiary prevention; transitional housing; vaccine development

DESCRIPTION (provided by applicant): The University of Maryland Baltimore (UMB) STAR TRACK Adolescent HIV Program (STAR TRACK Program) is a clinical and research unit with significant experience in the areas of adolescent HIV research. STAR TRACK is the only adolescent exclusive HIV service in the state of Maryland and has a comprehensive "one stop shopping" model of care, a state wide community outreach program, an HIV early identification program through an adolescent specific HIV counseling and testing unit, and a community researcher partnership Connect to Protect Baltimore. Our program has been one of 15 sites of the Adolescent HIV/AIDS Research Network (AMHARN) from 1994-2000 and the Adolescent Trials Network (ATN) from 2001 to present with a successful track record of recruitment, retention, site performance and quality assurance. At the present time, the ATN UMB unit is ranked first in recruitment out of the other 15 units nationally. Our PI, study coordinators, research assistants, and Youth Community Advisory Board member have productively participated in and contributed towards the ATN mission and its goals. Our program has extensive experience in the recruitment and retention of HIV+ and HIV- adolescents, in clinical care and research, has a caseload of 110 HFV+ youths (30 of who are in transition to adult care) and approximately 3,000 HIV-youths. STARTRACK has strong clinical and research collaborations with the two other UMB HIV clinics for adults and pediatric patients for a total of 228 active HIV infected young people under the age of 24 many of whom have research experience. Our program has highly experienced adolescent researchers and study coordinators as well as basic and clinical researchers of the Division of Pediatric Immunology and the Institute of Human Virology of the University of Maryland. These investigators have an extensive track record of leadership in multi center collaborative trials and have made significant contributions to the ATN research agenda by developing protocols and contributing in many ways to the research agenda. The tight interface between community outreach, early identification of HIV, linkage to care and research, and comprehensive primary and sub specialty care, intrinsic to STAR TRACK'S structure, facilitates the major goals of the ATN. These relationships also provide a great structure to expand subject recruitment. This application details the current clinical and research capacity of the Adolescent Medicine Trial Unit (AMTU) at the University of Maryland to conduct research protocols related to the primary, secondary and tertiary prevention of HIV. High-risk populations available for this research include high-risk sexual minority and heterosexual youths, as well as ethnic minority and substance abusing youths. In addition, it includes youths in transitional housing situations and school dropouts. Furthermore, the strong collaboration with an experienced laboratory, database manager and other University of Maryland scientists with expertise in HIV clinical trials and vaccine development provides an optimal environment for enriching the basic science and laboratory-based agenda of the ATN.

描述（由申请人提供）：马里兰州巴尔的摩大学（UMB）Star Track青少年艾滋病毒计划（Star Track Program）是一个临床和研究部门，在青少年艾滋病毒研究领域具有丰富的经验。 Star Track是马里兰州唯一的青少年独家艾滋病毒服务，并具有全面的“一站购物”护理模型，一项全州社区广泛的外展计划，通过青少年特定的艾滋病毒咨询和测试单位的艾滋病毒早期识别计划，以及一个社区研究人员的合作伙伴关系，以保护巴尔的摩。我们的计划是1994 - 2000年的青少年艾滋病毒/艾滋病研究网络（AMHARN）的15个地点之一，以及2001年的青少年试验网络（ATN），以成功地记录招聘，保留，现场绩效和质量保证的记录。目前，ATN UMB单位在全国其他15个单位中排名第一。我们的PI，研究协调员，研究助理和青年社区顾问委员会成员已有效地参与了ATN任务及其目标。我们的计划在临床护理和研究中招募和保留艾滋病毒+和艾滋病毒青少年方面具有丰富的经验，其案件为110 HFV+青年（其中30名正在过渡到成人护理）和大约3,000名HIV-Youths。 Startrack与其他两家UMB HIV诊所进行了强有力的临床和研究合作，为成人和儿科患者提供了228名活跃的HIV感染的年轻人，其中24名有24岁以下的年轻人，其中许多人都有研究经验。我们的计划拥有经验丰富的青少年研究人员和研究协调员，以及小儿免疫学系和马里兰大学人类病毒学研究所的基础和临床研究人员。这些研究者在多中心协作试验中具有广泛的领导能力记录，并通过制定协议并以许多方式为研究议程做出贡献，为ATN研究议程做出了重大贡献。社区外展，艾滋病毒的早期识别，与护理和研究的联系以及全面的初级和次级专业护理之间的紧密界面，与星际田径结构的内在融合，促进了ATN的主要目标。这些关系还为扩大主题招聘提供了很好的结构。该应用程序详细介绍了马里兰大学青少年医学试验单元（AMTU）的当前临床和研究能力，以执行与HIV的主要，次要和第三级预防有关的研究方案。这项研究可用的高风险人口包括高风险的性少数群体和异性恋年轻人，以及少数民族和滥用毒品的年轻人。此外，它包括过渡住房情况和学校辍学的年轻人。此外，与经验丰富的实验室，数据库经理和其他马里兰州大学科学家的强大合作在HIV临床试验和疫苗开发方面具有专业知识，为丰富了ATN的基础科学和实验室议程提供了一个最佳的环境。