OUTCOME MEASUREMENT OF MTBI IN CHILDREN AND ADOLESCENTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。虽然轻度创伤性脑损伤（mTBI）是儿童中最常见的损伤之一，但关于mTBI后儿童的恢复过程和长期功能后遗症，包括遗传因素的影响，目前还没有系统的研究。将多态等位基因与神经认知结果联系起来是确定某些基因是否有助于mTBI后恢复的一种策略。然而，等位基因多态性研究需要明确和有效的结果测量和样本大小适合感兴趣的等位基因的频率。本协议描述了国家儿童医学中心、匹兹堡大学医学中心、运动医学脑震荡项目和达特茅斯希区柯克医学中心之间一项为期4年、为期4年的多中心合作研究的第一阶段，即试点阶段。第一个目标是为6-18岁的儿童开发一套心理测量学上健全的测试系统，该测试系统易于管理，便携，可重复，同时在检测和监测儿童和青少年mTBI的神经认知和行为结果方面敏感。第二个目的是确定可能与mTBI后神经认知结果相关的选定候选基因的等位基因频率。总之，这些试点数据将为有效的遗传关联研究提供基础，以确定有助于儿童mTBI后神经认知恢复的遗传因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although mild traumatic brain injury (mTBI) is among the most common injuries in children, little systemic research has been done regarding the recovery process and long-term functional sequelae of children following mTBI, including the influence of genetic factors. Linking polymorphic alleles to neurocognitive outcome is one strategy to determine if certain genes contribute to recovery of after mTBI. However, allelic polymorphism studies require well-defined and validated outcome measures and sample sizes appropriate for the frequency of alleles of interest. This protocol describes the Phase 1, the piloting phase, of a 4-phase, 4-year-multi-center collaborative research study between Children's National Medical Center, University of Pittsburgh Medical Center, Sports Medicine Concussion Program, and Dartmouth Hitchcock Medical Center with two aims. The first aim is to develop a psychometrically-sound test battery for children aged 6-18 years that is easily administered, portable, and repeatable while sensitive in detecting and monitoring neurocognitive and behavioral outcomes of mTBI in children and adolescents. The second aim is to determine the allelic frequency of selected candidate genes that may be associated with neurocognitive outcome after mTBI. Together, these pilot data will provide the basis for a valid genetic association study for identifying genetic factors contributing to neurocognitive recovery after mTBI in children.