iTAKL: Imaging Telemetry And Kinematic modeLing in youth football

iTAKL：青少年足球中的成像遥测和运动学建模

• 批准号: 9306963
• 负责人: GERARD A. GIOIA
• 金额: $ 64.45万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9306963
• 关键词: 12 year old; Adverse effects; Age; Anisotropy; Area; Athletic; Attention; Behavior assessment; Biomechanics; Biometry; Brain; Brain Concussion; Brain Injuries; Child; Childhood; Cognitive; Collaborations; Collection; Computer Simulation; Control Groups; Craniocerebral Trauma; Data; Development; Diffuse; Diffusion Magnetic Resonance Imaging; Elements; Equipment; Functional Magnetic Resonance Imaging; Funding; Head; Health Sciences; Image; Incidence; Injury; Investments; Linear Regressions; Magnetic Resonance Imaging; Magnetoencephalography; Manufactured football; Measures; Methods; Modeling; Monitor; Motion; Neurocognitive; Neuropsychology; Participant; Perfusion; Predisposition; Recording of previous events; Recruitment Activity; Regression Analysis; Research; Research Personnel; Rest; Rotation; Scanning; Seasons; Slow-Wave Sleep; Spin Labels; Sports; System; Target Populations; Techniques; Telemetry; Time; Translating; Traumatic Brain Injury; United States National Institutes of Health; Universities; Work; Youth; base; clinical epidemiology; cognitive change; cognitive testing; college; data acquisition; data modeling; design; executive function; experience; forest; gray matter; head impact; high school; instrument; kinematics; mild traumatic brain injury; multimodality; neuroimaging; neuroinformatics; pediatric traumatic brain injury; prevent; prospective; public health relevance; research clinical testing

DESCRIPTION (provided by applicant). Football head injuries involve significant forces and can result in mild to severe traumatic brain injuries. While this has received increasing attention at the professional, collegiate, and high school levels, there is scarce if any data available for participants in the youth leagues (8-12 years old). This study will relate information about head motion during a hit in youth football to neurocognitive and imaging data to determine the effects of subconcussive impacts, and the true incidence of cognitive and objective imaging changes. All elements of this study focus on the objective to increase understanding of pediatric mild Traumatic Brain Injury (mTBI) and prospectively collect biomechanical, imaging, functional, and computational modeling data on a scale never before attempted. This project integrates neuroinformatics work and the computational modeling techniques developed by Drs. Maldjian and Stitzel at Wake Forest University Health Sciences (WFUHS). It leverages the investments by WFUHS which has identified, instrumented, and begun recruiting the target population and funding the initial year as part of our ongoing work in this area of critical public importance. Th long term benefit of the research will be to allow equipment designers, researchers, and clinicians to better prevent, mitigate, identify and treat injuries to help make youth league football a safer activity for millions of children.

描述(由申请人提供)。足球头部损伤涉及巨大的力量，可能导致轻微到严重的创伤性脑损伤。虽然这受到了越来越多的关注 在专业、大学和高中各级，青年联盟(8-12岁)的参与者几乎没有可用的数据。本研究将有关青少年足球击球时头部运动的信息与神经认知和成像数据相关联，以确定亚震荡撞击的影响，以及认知和客观成像变化的真实发生率。这项研究的所有要素都集中在目标上，目的是增加对儿童轻度创伤性脑损伤(MTBI)的了解，并前瞻性地收集前所未有的规模的生物力学、成像、功能和计算建模数据。该项目整合了神经信息学工作和维克森林大学健康科学(WFUHS)的马尔德健和斯蒂泽尔博士开发的计算建模技术。它利用了WFUHS的投资，WFUHS已经确定、利用并开始招募目标人口，并为最初一年提供资金，作为我们在这一具有关键公共重要性的领域正在进行的工作的一部分。这项研究的长期好处将是使设备设计师、研究人员和临床医生能够更好地预防、减轻、识别和治疗伤害，帮助使青少年足球成为数百万儿童的一项更安全的活动。