OUTCOME MEASUREMENT OF MTBI IN CHILDREN AND ADOLESCENTS

儿童和青少年 MTBI 的结果测量

• 批准号: 8167301
• 负责人: GERARD A. GIOIA
• 金额: $ 0.05万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167301
• 关键词: 18 year old; Adolescent; Age; Alleles; Area; Back; Behavioral; Child; Childhood; Childhood Injury; Clinical; Complex; Computer Retrieval of Information on Scientific Projects Database; Development; Education; Funding; Gene Frequency; Genes; Genetic; Genetic Polymorphism; Grant; Institution; Link; Measurement; Measures; Medical center; Neurocognitive; Outcome; Outcome Measure; Phase; Process; Protocols documentation; Psychometrics; Recovery; Research; Research Personnel; Resources; Sample Size; Sensitivity and Specificity; Short-Term Memory; Source; Testing; Traumatic Brain Injury; United States National Institutes of Health; Universities; Validation; interest; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although mild traumatic brain injury (mTBI) is among the most common injuries in children, little systemic research has been done regarding the recovery process and long-term functional sequelae of children following mTBI, including the influence of genetic factors. Linking polymorphic alleles to neurocognitive outcome is one strategy to determine if certain genes contribute to recovery after mTBI. However, allelic polymorphism studies require well-defined and validated outcome measures and sample sizes appropriate for the frequency of alleles of interest. This protocol describes the Phase 1, the piloting phase, of a 4-phase, 6-year-multi-center collaborative research study between Children's National Medical Center, the Department of Education-Kaua'i Complex Area, University of Pittsburgh Medical Center, A.T. Still University and Dartmouth Hitchcock Medical Center. The aim of Phase 1, which has already been completed, was the initial development and adaptation of the three principal tests of the mTBI battery for the pediatric age range (5-18 years) - ImPACT, the BRIEF, and the N-back working memory measure. The specific aim of Phase 2 is the psychometric development of the tests with the mTBI battery including norming, test-retest reliability, and concurrent validity across the 5-18 year age range. The specific aim of Phase 3 is clinical validation, i.e., to establish the sensitivity and specificity of the mTBI battery to detect neruocognitive and behavioral changes in children with mTBI.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 虽然轻度创伤性脑损伤（mTBI）是儿童最常见的损伤之一，但关于mTBI后儿童的恢复过程和长期功能后遗症的系统研究很少，包括遗传因素的影响。将多态性等位基因与神经认知结果联系起来是确定某些基因是否有助于mTBI后恢复的一种策略。然而，等位基因多态性研究需要明确定义和验证的结果措施和样本量适合的等位基因的频率感兴趣。本方案描述了一项4期、6年多中心合作研究的第1期（试点阶段），该研究由儿童国家医学中心、教育部-考艾岛综合区、匹兹堡大学医学中心、A.T.斯蒂尔大学和达特茅斯希区柯克医学中心。已经完成的第1阶段的目的是初步开发和调整儿童年龄范围（5-18岁）的mTBI组合的三个主要测试- ImPACT，BRIEF和N-back工作记忆测量。 第2阶段的具体目标是开发mTBI成套测试的心理测量学，包括标准化、重测信度和5-18岁年龄范围内的同时效度。第3阶段的具体目标是临床验证，即，建立mTBI成套测验检测mTBI儿童神经认知和行为变化的敏感性和特异性。