NEUROBEHAVIORAL EVALUATION CORE

神经行为评估核心

• 批准号: 7714626
• 负责人: GERARD A. GIOIA
• 金额: $ 22.44万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714626
• 关键词: Adolescent; Adult; Affect; Area; Attention; Behavior; Behavioral; Biochemical; Budgets; Child; Clinical Research; Clinical Trials; Cognition; Cognitive; Complex; Condition; Consult; Consultations; Coupled; Critiques; Data Collection; Data Quality; Depth; Development; Disease; Epilepsy; Evaluation; Explosion; Functional Magnetic Resonance Imaging; Future; Genetic; Goals; Grant; Human Resources; Improve Access; Infant; Intelligence; Intervention; Investigation; Knowledge; Language; Libraries; Link; Manuscripts; Materials Testing; Measures; Medical; Memory; Mental Retardation and Developmental Disabilities Research Centers; Methodology; Methods; Modeling; Molecular Genetics; Monitor; Neurodevelopmental Disorder; Neuropsychological Tests; Numbers; Outcome; Pediatric Research; Performance; Phenotype; Population Study; Preparation; Principal Investigator; Process; Proteomics; Protocols documentation; Purpose; Quality of life; Research; Research Personnel; Research Project Grants; Research Support; Safety; Score; Services; Specific qualifier value; Staging; Study Section; Suggestion; Testing; Time; Training; Validation; behavior measurement; cost; design; executive function; functional status; instrument; investigator training; knowledge base; lectures; literacy; medical specialties; neurobehavioral; neurobehavioral disorder; neurogenetics; neuroimaging; neuropsychological; psychosocial; research study; response; skills; tool; urea cycle

A. OBJECTIVES In the critique of our MRDDRC application in 2001 the study section stated (p.5): behavioral expertise will need to be added to the Center to provide better input into this area at an early stage of grant development. In response to this suggestion we propose to develop the Neurobehavioral Evaluation Core (NEC) that will provide investigators with this expertise. The primary objective of the NEC is to provide sophisticated neurobehavioral and neuropsychological research support to MRDDRC projects, and to develop or validate new methods for this purpose. Scientific advancement of our understanding of complex neurobehavioral disorders of development is facilitated greatly by our ability to reliably and precisely define the developmental and behavioral phenotype. Measurement of behavioral and cognitive variables is crucial in studies of disease and development that comprise our MRDDRC. Over the past 3-5 years, there has been a substantial increase in the number of MRDDRC projects with a behavioral and/or psychosocial focus. The aims of these studies have been on the developmental, cognitive, and behavioral outcomes in children who have a variety of neurogenetic, neurodevelopmental, or acquired disorders that affect cognition and behaivor. In addition to a rigorous study of the underlying medical condition (e.g. urea cycle disorders or epilepsy), these investigations aim to describe the impact on the child's cognitive and behavioral development. Twenty to thirty years ago, this type of research might have focused on the broad aspects of development, such as the level of intelligence of these children. Newer methods allow a far more in depth focus into such critical developmental factors as attention, executive function, and memory subprocesses. The explosion of developmental neuropsychological knowledge base linking underlying neurological development and disorder with behavioral and cognitive development has further fueled the need for pediatric research to include sophisticated models of neurobehavioral and neuropsychological function. Historically, many studies that could have potentially benefited from examination of neuropsychological and neurobehavioral variables have not included such assessments because of: 1) limited knowledge regarding available measures; 2) cost-constraints within research project budgets for expert personnel and/or purchase of testing materials; and 3) lack of access to personnel skilled in the performance of these assessments. The primary goal of the NEC is to improve access to appropriate measures and to enhance the overall quality of neurobehavioral research being conducted throughout the MRDDRC. Within the NEC, we propose to: 1) provide access to an extensive battery of neuropsychological testing services; 2) develop and administer neurobehavioral tasks for neuroimaging protocols, including fMRI projects through the Neuroimaging Core; 3) provide consultation to MRDDRC investigators on the proper design and use of neurobehavioral and neuropsychological measures in research studies; and 4) train investigators and their staff in the use of these measures. With this increased sophistication investigators will be able to assess several levels of neurobehavioral outcome, e.g., specific neuropsychological processes, such as memory or executive function, together with quality of life functional status. This will be able to be coupled with studies exploring etiologic factors at the genetic level (utilizing the Molecular Genetics, Proteomics and Biochemical Analysis Core) and neuropathophysiologic level (using the Neuroimaging Core).

A.目标 在2001年对MRDDRC申请的批评中，研究部分表示（第5页）：行为专业知识将需要 要添加到中心，以在赠款开发的早期阶段为该领域提供更好的投入。在 对此建议，我们建议开发神经行为评估核心（NEC） 为调查人员提供此专业知识。 NEC的主要目的是提供复杂的 对MRDDRC项目的神经行为和神经心理学研究支持，并开发或验证 为此目的的新方法。我们对复杂神经行为的理解的科学发展 发展障碍是由于我们可靠，精确定义发展的能力而极大地促进了发展 和行为表型。 对行为和认知变量的测量对于疾病和发育研究至关重要 包括我们的MRDDRC。在过去的3 - 5年中，数量已大幅增加 MRDDRC以行为和/或社会心理重点进行项目。这些研究的目的是 具有多种神经遗传学的儿童的发展，认知和行为结果 神经发育或产生影响认知和行为的疾病。除了严格的研究 这些调查旨在描述潜在的医疗状况（例如尿素周期疾病或癫痫病） 对孩子的认知和行为发展的影响。二十到三十年前，这种类型的 研究可能专注于发展的广泛方面，例如这些智能的水平 孩子们。较新的方法可以更深入地关注关注的关键发展因素，例如 执行功能和内存子过程。发育神经心理学的爆炸 知识基础将潜在的神经系统发展和混乱与行为和认知联系起来 开发进一步加剧了小儿研究的需求，包括 神经行为和神经心理学功能。 从历史上看，许多可能受益于神经心理学和 神经行为变量尚未包括以下评估，因为：1）关于 可用措施； 2）专家人员和/或购买的研究项目预算中的成本约束 测试材料； 3）缺乏获得这些评估表现的人员的机会。这 NEC的主要目标是改善获得适当措施的机会，并提高总体质量 整个MRDDRC进行了神经行为研究。 在NEC中，我们建议：1）提供大量神经心理学测试的访问权限 服务； 2）开发和管理神经影像学方案的神经行为任务，包括fIMRI项目 通过神经成像核心； 3）就适当的设计和MRDDRC调查人员提供咨询 研究研究中的神经行为和神经心理学措施； 4）培训调查人员和 他们的员工使用这些措施。随着这种复杂的调查人员的提高，将能够评估 几个级别的神经行为结果，例如特定的神经心理学过程，例如记忆或 执行功能，以及生活质量功能状态。这将能够与研究结合 在遗传水平上探索病因因子（利用分子遗传学，蛋白质组学和生化 分析核心）和神经病理生理水平（使用神经成像核心）。