NEUROBEHAVIORAL EVALUATION CORE

神经行为评估核心

• 批准号: 7714626
• 负责人: GERARD A. GIOIA
• 金额: $ 22.44万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714626
• 关键词: Adolescent; Adult; Affect; Area; Attention; Behavior; Behavioral; Biochemical; Budgets; Child; Clinical Research; Clinical Trials; Cognition; Cognitive; Complex; Condition; Consult; Consultations; Coupled; Critiques; Data Collection; Data Quality; Depth; Development; Disease; Epilepsy; Evaluation; Explosion; Functional Magnetic Resonance Imaging; Future; Genetic; Goals; Grant; Human Resources; Improve Access; Infant; Intelligence; Intervention; Investigation; Knowledge; Language; Libraries; Link; Manuscripts; Materials Testing; Measures; Medical; Memory; Mental Retardation and Developmental Disabilities Research Centers; Methodology; Methods; Modeling; Molecular Genetics; Monitor; Neurodevelopmental Disorder; Neuropsychological Tests; Numbers; Outcome; Pediatric Research; Performance; Phenotype; Population Study; Preparation; Principal Investigator; Process; Proteomics; Protocols documentation; Purpose; Quality of life; Research; Research Personnel; Research Project Grants; Research Support; Safety; Score; Services; Specific qualifier value; Staging; Study Section; Suggestion; Testing; Time; Training; Validation; behavior measurement; cost; design; executive function; functional status; instrument; investigator training; knowledge base; lectures; literacy; medical specialties; neurobehavioral; neurobehavioral disorder; neurogenetics; neuroimaging; neuropsychological; psychosocial; research study; response; skills; tool; urea cycle

A. OBJECTIVES In the critique of our MRDDRC application in 2001 the study section stated (p.5): behavioral expertise will need to be added to the Center to provide better input into this area at an early stage of grant development. In response to this suggestion we propose to develop the Neurobehavioral Evaluation Core (NEC) that will provide investigators with this expertise. The primary objective of the NEC is to provide sophisticated neurobehavioral and neuropsychological research support to MRDDRC projects, and to develop or validate new methods for this purpose. Scientific advancement of our understanding of complex neurobehavioral disorders of development is facilitated greatly by our ability to reliably and precisely define the developmental and behavioral phenotype. Measurement of behavioral and cognitive variables is crucial in studies of disease and development that comprise our MRDDRC. Over the past 3-5 years, there has been a substantial increase in the number of MRDDRC projects with a behavioral and/or psychosocial focus. The aims of these studies have been on the developmental, cognitive, and behavioral outcomes in children who have a variety of neurogenetic, neurodevelopmental, or acquired disorders that affect cognition and behaivor. In addition to a rigorous study of the underlying medical condition (e.g. urea cycle disorders or epilepsy), these investigations aim to describe the impact on the child's cognitive and behavioral development. Twenty to thirty years ago, this type of research might have focused on the broad aspects of development, such as the level of intelligence of these children. Newer methods allow a far more in depth focus into such critical developmental factors as attention, executive function, and memory subprocesses. The explosion of developmental neuropsychological knowledge base linking underlying neurological development and disorder with behavioral and cognitive development has further fueled the need for pediatric research to include sophisticated models of neurobehavioral and neuropsychological function. Historically, many studies that could have potentially benefited from examination of neuropsychological and neurobehavioral variables have not included such assessments because of: 1) limited knowledge regarding available measures; 2) cost-constraints within research project budgets for expert personnel and/or purchase of testing materials; and 3) lack of access to personnel skilled in the performance of these assessments. The primary goal of the NEC is to improve access to appropriate measures and to enhance the overall quality of neurobehavioral research being conducted throughout the MRDDRC. Within the NEC, we propose to: 1) provide access to an extensive battery of neuropsychological testing services; 2) develop and administer neurobehavioral tasks for neuroimaging protocols, including fMRI projects through the Neuroimaging Core; 3) provide consultation to MRDDRC investigators on the proper design and use of neurobehavioral and neuropsychological measures in research studies; and 4) train investigators and their staff in the use of these measures. With this increased sophistication investigators will be able to assess several levels of neurobehavioral outcome, e.g., specific neuropsychological processes, such as memory or executive function, together with quality of life functional status. This will be able to be coupled with studies exploring etiologic factors at the genetic level (utilizing the Molecular Genetics, Proteomics and Biochemical Analysis Core) and neuropathophysiologic level (using the Neuroimaging Core).

A. 目标 在 2001 年对我们的 MRDDRC 应用程序的批评中，研究部分指出（第 5 页）：行为专业知识将需要 将被添加到该中心，以便在赠款开发的早期阶段为该领域提供更好的投入。在 为了回应这一建议，我们建议开发神经行为评估核心（NEC），它将 为研究人员提供这方面的专业知识。 NEC 的主要目标是提供先进的 为 MRDDRC 项目提供神经行为和神经心理学研究支持，并开发或验证 为此目的的新方法。我们对复杂神经行为理解的科学进步 我们能够可靠而准确地定义发育障碍，这极大地促进了发育障碍的发生。 和行为表型。 行为和认知变量的测量对于疾病和发育的研究至关重要 组成我们的 MRDDRC。近3-5年，人数大幅增加 MRDDRC 项目以行为和/或社会心理为重点。这些研究的目的是 患有各种神经遗传、 影响认知和行为的神经发育或后天障碍。除了严格的研究 潜在的医疗状况（例如尿素循环障碍或癫痫），这些调查旨在描述 对孩子认知和行为发展的影响。二十、三十年前，这种 研究可能集中于发展的广泛方面，例如这些人的智力水平 孩子们。较新的方法可以更深入地关注注意力等关键发展因素， 执行功能和记忆子过程。发育神经心理学的爆炸式增长 将潜在的神经发育和障碍与行为和认知联系起来的知识库 的发展进一步推动了儿科研究的需要，包括复杂的模型 神经行为和神经心理功能。 从历史上看，许多研究可能受益于神经心理学和神经心理学的检查。 神经行为变量未包括此类评估，因为：1）关于神经行为变量的知识有限 可用措施； 2) 研究项目预算内专家人员和/或采购的成本限制 测试材料； 3) 缺乏熟练执行这些评估的人员。这 NEC 的主要目标是改善获得适当措施的机会并提高整体质量 MRDDRC 正在开展神经行为研究。 在 NEC 内，我们建议：1）提供广泛的神经心理学测试 服务； 2) 开发和管理神经影像协议的神经行为任务，包括功能磁共振成像项目 通过神经影像核心； 3) 向 MRDDRC 调查人员提供关于正确设计和 在研究中使用神经行为和神经心理学措施； 4) 培训调查员和 他们的工作人员正在使用这些措施。随着复杂性的提高，研究人员将能够评估 几个层面的神经行为结果，例如特定的神经心理过程，例如记忆或 执行功能，以及生活质量功能状态。这将能够与研究相结合 在基因水平探索病因（利用分子遗传学、蛋白质组学和生物化学） 分析核心）和神经病理生理学水平（使用神经影像核心）。