OUTCOME MEASUREMENT OF MTBI IN CHILDREN AND ADOLESCENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 虽然轻度创伤性脑损伤（mTBI）是儿童最常见的损伤之一，但关于mTBI后儿童的恢复过程和长期功能后遗症的系统研究很少，包括遗传因素的影响。将多态性等位基因与神经认知结果联系起来是确定某些基因是否有助于mTBI后恢复的一种策略。然而，等位基因多态性研究需要明确定义和验证的结果措施和样本量适合的等位基因的频率感兴趣。本方案描述了儿童国家医学中心、匹兹堡大学医学中心、运动医学脑震荡项目和达特茅斯希区柯克医学中心之间的一项4期、4年多中心合作研究的第1阶段（试点阶段），该研究有两个目的。第一个目标是为6-18岁的儿童开发一种心理测量学健全的测试组合，该测试组合易于管理，便携式和可重复，同时在检测和监测儿童和青少年mTBI的神经认知和行为结果方面灵敏。第二个目的是确定可能与mTBI后神经认知结果相关的选定候选基因的等位基因频率。总之，这些试验数据将为有效的遗传关联研究提供基础，以确定有助于儿童mTBI后神经认知恢复的遗传因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although mild traumatic brain injury (mTBI) is among the most common injuries in children, little systemic research has been done regarding the recovery process and long-term functional sequelae of children following mTBI, including the influence of genetic factors. Linking polymorphic alleles to neurocognitive outcome is one strategy to determine if certain genes contribute to recovery of after mTBI. However, allelic polymorphism studies require well-defined and validated outcome measures and sample sizes appropriate for the frequency of alleles of interest. This protocol describes the Phase 1, the piloting phase, of a 4-phase, 4-year-multi-center collaborative research study between Children's National Medical Center, University of Pittsburgh Medical Center, Sports Medicine Concussion Program, and Dartmouth Hitchcock Medical Center with two aims. The first aim is to develope a psychometrically-sound test battery for children aged 6-18 years that is easily administered, portable, and repeatable while sensitive in detecting and monitoring neurocognitive and behavioral outcomes of mTBI in children and adolescents. The second aim is to determine the allelic frequency of selected candidate genes that may be associated with neurocognitive outcome after mTBI. Together, these pilot data will provide the basis for a valid genetic association study for identifying genetic factors contributing to neurocognitive recovery after mTBI in children.