OUTCOME MEASUREMENT OF MTBI IN CHILDREN AND ADOLESCENTS

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 尽管轻度创伤性脑损伤（mTBI）是儿童最常见的损伤之一，但关于mTBI后儿童的恢复过程和长期功能后遗症（包括遗传因素的影响）的系统研究却很少。将多态性等位基因与神经认知结果联系起来是确定某些基因是否有助于 mTBI 后恢复的一种策略。然而，等位基因多态性研究需要明确且经过验证的结果测量以及适合感兴趣等位基因频率的样本量。该协议描述了国家儿童医学中心、匹兹堡大学医学中心、运动医学脑震荡项目和达特茅斯希区柯克医疗中心之间为期 4 个阶段、为期 4 年的多中心合作研究的第一阶段，即试点阶段，有两个目标。第一个目标是为 6-18 岁儿童开发一种心理测量健全的测试电池，该测试电池易于管理、便携且可重复，同时能够灵敏地检测和监测儿童和青少年 mTBI 的神经认知和行为结果。第二个目标是确定可能与 mTBI 后神经认知结果相关的选定候选基因的等位基因频率。总之，这些试点数据将为有效的遗传关联研究提供基础，以识别有助于儿童 mTBI 后神经认知恢复的遗传因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although mild traumatic brain injury (mTBI) is among the most common injuries in children, little systemic research has been done regarding the recovery process and long-term functional sequelae of children following mTBI, including the influence of genetic factors. Linking polymorphic alleles to neurocognitive outcome is one strategy to determine if certain genes contribute to recovery of after mTBI. However, allelic polymorphism studies require well-defined and validated outcome measures and sample sizes appropriate for the frequency of alleles of interest. This protocol describes the Phase 1, the piloting phase, of a 4-phase, 4-year-multi-center collaborative research study between Children's National Medical Center, University of Pittsburgh Medical Center, Sports Medicine Concussion Program, and Dartmouth Hitchcock Medical Center with two aims. The first aim is to develope a psychometrically-sound test battery for children aged 6-18 years that is easily administered, portable, and repeatable while sensitive in detecting and monitoring neurocognitive and behavioral outcomes of mTBI in children and adolescents. The second aim is to determine the allelic frequency of selected candidate genes that may be associated with neurocognitive outcome after mTBI. Together, these pilot data will provide the basis for a valid genetic association study for identifying genetic factors contributing to neurocognitive recovery after mTBI in children.