Aetiology pathogenesis and immunology of post-weaning multi-systemic wasting syndrome in pigs: genetic-environmental interactions

猪断奶后多系统消耗综合征的病因、发病机制和免疫学：遗传-环境相互作用

• 批准号: BB/E018394/1
• 负责人: Dirk Werling
• 金额: $ 242.99万
• 依托单位: Royal Veterinary College
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FE018394%2F1
• 关键词: Aetiology; pathogenesis; immunology; post; weaning

Post-weaning multi-systemic wasting syndrome (PMWS) is a common disease of young pigs in the U.K. It is extremely debilitating, causes considerable suffering and poor welfare, and has a high mortality of up to 20%. The disease was first recognised in 1991 and is now prevalent worldwide. Since over 1.2 billion pigs are reared annually for human consumption, then there are good commercial and ethical reasons why new diseases like PMWS should be controlled or eliminated to ensure a safe, humane and sustainable supply of pork, sausages and ham. At first scientists thought that PMWS was caused by a virus but they now realise that genetic and environmental factors must be involved, along with opportunistic secondary pathogens. This project proposes a unique interdisciplinary approach to investigate this endemic disease and will integrate modern scientific techniques from epidemiology, genetics, microbiology, pathology, molecular immunology and environmental science to identify why PMWS occurs, leading to new control methods. British pig farmers will be heavily involved in the project, thereby guaranteeing that pigs in Britain will be the first to benefit from this research, while collaboration with a major international pharmaceutical company will ensure that new veterinary products will be made available to pig farmers worldwide.

断奶后多系统衰竭综合征（PMWS）是英国仔猪的一种常见病。这是非常衰弱，造成相当大的痛苦和福利差，并有高达20%的死亡率。该病于1991年首次被发现，目前在全球范围内流行。由于每年有超过12亿头猪被饲养供人类食用，因此有充分的商业和道德理由来控制或消除PMWS等新疾病，以确保安全，人道和可持续的猪肉，香肠和火腿供应。起初，科学家们认为PMWS是由病毒引起的，但他们现在意识到，遗传和环境因素必须与机会性继发病原体一起沿着。该项目提出了一种独特的跨学科方法来调查这种地方病，并将整合流行病学，遗传学，微生物学，病理学，分子免疫学和环境科学的现代科学技术，以确定PMWS发生的原因，从而导致新的控制方法。英国养猪户将积极参与该项目，从而保证英国的猪将首先从这项研究中受益，而与一家大型国际制药公司的合作将确保向全球养猪户提供新的兽医产品。

项目成果

Global gene expression profiling of myeloid immune cell subsets in response to in vitro challenge with porcine circovirus 2b.

• DOI: 10.1371/journal.pone.0091081
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Mavrommatis B;Offord V;Patterson R;Watson M;Kanellos T;Steinbach F;Grierson S;Werling D
• 通讯作者: Werling D

Making sense of PMWS, PCV2, PCVD

了解 PMWS、PCV2、PCVD

• 作者: Barbara Wieland (Author)

Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b.

• DOI: 10.1016/j.vetmic.2015.03.010
• 发表时间: 2015-06-12
• 期刊: VETERINARY MICROBIOLOGY
• 影响因子: 3.3
• 作者: Patterson, Robert;Neyel, Amanda;Diaz, Adriana V.;Martineau, Henny M.;Demmers, Theo;Browne, Christopher;Mavrommatis, Bettina;Werling, Dirk
• 通讯作者: Werling, Dirk

BPEX Pig Health Scheme: a useful monitoring system for respiratory disease control in pig farms?

• DOI: 10.1186/1746-6148-7-82
• 发表时间: 2011-12-30
• 期刊: BMC VETERINARY RESEARCH
• 影响因子: 2.6
• 作者: Holt, Hannah R.;Alarcon, Pablo;Wieland, Barbara
• 通讯作者: Wieland, Barbara

Cost of post-weaning multi-systemic wasting syndrome and porcine circovirus type-2 subclinical infection in England - an economic disease model.

• DOI: 10.1016/j.prevetmed.2013.02.010
• 发表时间: 2013-06-01
• 期刊: Preventive veterinary medicine
• 影响因子: 2.6
• 作者: Alarcon P;Rushton J;Wieland B
• 通讯作者: Wieland B