Antimicrobials and improved diagnostics towards integrated control of CBPP

抗菌剂和改进的诊断以实现 CBPP 的综合控制

基本信息

  • 批准号:
    BB/H009450/1
  • 负责人:
  • 金额:
    $ 92.47万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2010
  • 资助国家:
    英国
  • 起止时间:
    2010 至 无数据
  • 项目状态:
    已结题

项目摘要

CBPP is a bacterial pneumonia of cattle in Africa that causes major economic losses to livestock farmers and national governments in affected countries. These arise chiefly from the death of infected cattle and the reduced productivity of those that survive. A feature of the disease is that cattle continue to shed the pathogen for a variable period after they have apparently recovered. These are known as carrier animals and, because of them, animal movement plays a major role in the spread of the disease. As a result, the presence of the CBPP in a country often imposes trade barriers on livestock products. Considerable resources are therefore invested by national governments in attempts to control or eradicate the disease. Control of CBPP is generally the responsibility of the state veterinary services and relies on the use of live attenuated vaccines, which are not available to individual farmers. These are deployed either annually or in the face of outbreaks. However, available vaccines have limited efficacy, and because state veterinary services are often under-resourced, the necessary vaccine coverage is rarely achieved. Farmers therefore often revert to the use of antibiotics to treat cattle that they believe are infected. Unfortunately, there is little information on the efficacy of antibiotics for treatment of CBPP infected cattle and some studies suggest that these interventions have no benefit. In addition, the use of antibiotics in the face of CBPP has been controversial because of the belief that it promotes establishment of the carrier state. Indeed, use of antibiotics for treatment of CBPP is discouraged or banned in most affected countries. Notwithstanding this, the failure of vaccine-based control strategies to limit the spread of CBPP in Africa has led to calls for a re-evaluation of the role of antimicrobials in its control. In addition, mathematical modeling studies have predicted that, used in conjunction with available vaccines, effective antimicrobials would have a high chance of success in eradicating the disease from infected herds. This project will apply advanced pharmacological methods to evaluate three antimicrobial compounds for their efficacy against the CBPP bacterium and develop rational dosage strategies for their deployment as control tools in the field. The project will also develop a diagnostic test capable of recognising cattle in the early stages of infection, using a format applicable at the crush side or point-of-care, to inform decisions to treat.
CBPP是非洲牛的细菌性肺炎,对受影响国家的畜牧业农民和国家政府造成重大经济损失。这主要是由于受感染的牛死亡和幸存牛的生产力下降。这种疾病的一个特点是,牛在明显康复后的一段时间内继续散发病原体。这些被称为携带者动物,因为它们,动物运动在疾病传播中起着重要作用。因此,一个国家的CBPP的存在往往对畜产品施加贸易壁垒。因此,各国政府投入了大量资源,试图控制或根除这一疾病。CBPP的控制通常由国家兽医服务部门负责,并依赖于使用减毒活疫苗,而这些疫苗不适用于个体农民。每年或在面临疫情时部署这些人员。然而,现有的疫苗效力有限,而且由于国家兽医服务往往资源不足,很少达到必要的疫苗覆盖率。因此,农民们经常使用抗生素来治疗他们认为被感染的牛。不幸的是,关于抗生素治疗CBPP感染牛的有效性的信息很少,一些研究表明这些干预措施没有益处。此外,在CBPP面前使用抗生素一直存在争议,因为人们认为它会促进携带者状态的建立。事实上,大多数受影响的国家不鼓励或禁止使用抗生素治疗CBPP。尽管如此,基于疫苗的控制策略未能限制CBPP在非洲的传播,这导致人们呼吁重新评估抗菌剂在控制中的作用。此外,数学建模研究预测,与现有疫苗结合使用,有效的抗菌剂将有很高的成功机会从受感染的牛群中根除疾病。该项目将采用先进的药理学方法来评估三种抗菌化合物对CBPP细菌的有效性,并制定合理的剂量策略,以将其作为现场控制工具进行部署。该项目还将开发一种诊断测试,能够在感染的早期阶段识别牛,使用适用于挤压侧或护理点的格式,以告知治疗决定。

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Control of contagious bovine pleuropneumonia: knowledge, attitudes, perceptions and practices in Narok district of Kenya.
  • DOI:
    10.1016/j.prevetmed.2014.03.029
  • 发表时间:
    2014-08-01
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
    Kairu-Wanyoike SW;Kiara H;Heffernan C;Kaitibie S;Gitau GK;McKeever D;Taylor NM
  • 通讯作者:
    Taylor NM
Vaccination of cattle with the N terminus of LppQ of Mycoplasma mycoides subsp. mycoides results in type III immune complex disease upon experimental infection.
  • DOI:
    10.1128/iai.00003-15
  • 发表时间:
    2015-05
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    Mulongo M;Frey J;Smith K;Schnier C;Wesonga H;Naessens J;McKeever D
  • 通讯作者:
    McKeever D
Pharmacodynamics of antimicrobials against Mycoplasma mycoides mycoides small colony, the causative agent of contagious bovine pleuropneumonia.
  • DOI:
    10.1371/journal.pone.0044158
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Mitchell JD;McKellar QA;McKeever DJ
  • 通讯作者:
    McKeever DJ
Willingness to pay for contagious bovine pleuropneumonia vaccination in Narok South District of Kenya.
  • DOI:
    10.1016/j.prevetmed.2014.03.028
  • 发表时间:
    2014-08-01
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
    Kairu-Wanyoike SW;Kaitibie S;Heffernan C;Taylor NM;Gitau GK;Kiara H;McKeever D
  • 通讯作者:
    McKeever D
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Dirk Werling其他文献

WC1(+) gammadelta T cells indirectly regulate chemokine production during mycobacterium bovis infection in SCID-bo mice.
WC1( ) gammadelta T 细胞在 SCID-bo 小鼠牛分枝杆菌感染期间间接调节趋化因子的产生。
Therapeutic targeting of the innate immune system in domestic animals
  • DOI:
    10.1007/s00441-010-1054-9
  • 发表时间:
    2010-10-16
  • 期刊:
  • 影响因子:
    2.900
  • 作者:
    Tracey J. Coffey;Dirk Werling
  • 通讯作者:
    Dirk Werling
TITLE: Analysis of Genetic Variation in the Bovine SLC11A1 Gene, Its Influence on the Expression of NRAMP1 and Potential Association With Resistance to Bovine Tuberculosis AUTHORS:
标题:牛 SLC11A1 基因遗传变异分析、其对 NRAMP1 表达的影响以及与牛结核病耐药性的潜在关联
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Angela Holder;Rachel Garty;Charlotte Elder;Paula Mesnard;Celine Laquerbe;Marie;M. Salavati;Muhammad Zubair Shabbir;Thomas Tzelos;Timothy Connelly;Bernardo Villarreal;Dirk Werling
  • 通讯作者:
    Dirk Werling
Multi-omics analysis reveals regime shifts in the gastrointestinal ecosystem in chickens following anticoccidial vaccination and emEimeria tenella/em challenge
多组学分析揭示了鸡在抗球虫疫苗接种和柔嫩艾美耳球虫感染后胃肠道生态系统的转变。
  • DOI:
    10.1128/msystems.00947-24
  • 发表时间:
    2024-09-17
  • 期刊:
  • 影响因子:
    4.600
  • 作者:
    Po-Yu Liu;Janie Liaw;Francesca Soutter;José Jaramillo Ortiz;Fiona M. Tomley;Dirk Werling;Ozan Gundogdu;Damer P. Blake;Dong Xia
  • 通讯作者:
    Dong Xia
Toll-like receptors in domestic animals
  • DOI:
    10.1007/s00441-010-1047-8
  • 发表时间:
    2010-10-07
  • 期刊:
  • 影响因子:
    2.900
  • 作者:
    Thomas W. Jungi;Katja Farhat;Iwan A. Burgener;Dirk Werling
  • 通讯作者:
    Dirk Werling

Dirk Werling的其他文献

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{{ truncateString('Dirk Werling', 18)}}的其他基金

Protecting Pigs From Enzootic Pneumonia: Rational Design Of Safe Attenuated Vaccines.
保护猪免受地方性肺炎:安全减毒疫苗的合理设计。
  • 批准号:
    BB/X017540/1
  • 财政年份:
    2023
  • 资助金额:
    $ 92.47万
  • 项目类别:
    Research Grant
22-ICRAD Call 2 Comparative host and species-specific immune responses of macrophages infected with zoonotic Leptospira interrogans
22-ICRAD Call 2 感染人畜共患问号钩端螺旋体的巨噬细胞的宿主和物种特异性免疫反应比较
  • 批准号:
    BB/X020061/1
  • 财政年份:
    2023
  • 资助金额:
    $ 92.47万
  • 项目类别:
    Research Grant
Establishment of an Organ-on-a-chip facility for Veterinary Species
建立兽医物种器官芯片设施
  • 批准号:
    BB/X019675/1
  • 财政年份:
    2023
  • 资助金额:
    $ 92.47万
  • 项目类别:
    Research Grant
Creating a bovine C-type lectin receptor atlas and identification of their ligands
牛C型凝集素受体图谱的创建及其配体的鉴定
  • 批准号:
    BB/P008461/1
  • 财政年份:
    2017
  • 资助金额:
    $ 92.47万
  • 项目类别:
    Research Grant
Aetiology pathogenesis and immunology of post-weaning multi-systemic wasting syndrome in pigs: genetic-environmental interactions
猪断奶后多系统消耗综合征的病因、发病机制和免疫学:遗传-环境相互作用
  • 批准号:
    BB/E018394/1
  • 财政年份:
    2008
  • 资助金额:
    $ 92.47万
  • 项目类别:
    Research Grant

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