Optimising yield of antioxidants and sunscreens in microalgae for sustainable biosythesis of ingredients for health and beauty products

优化微藻中抗氧化剂和防晒霜的产量，以实现健康和美容产品成分的可持续生物合成

• 批准号: BB/E01898X/1
• 负责人: Simon Davies
• 金额: $ 5.52万
• 依托单位: Plymouth University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FE01898X%2F1
• 关键词: Optimising; yield; antioxidants; sunscreens; microalgae

Microalgae, microscopic plants ubiqitous in the world's oceans, are nature's very own power cells converting light energy from the sun into chemical compounds. The high biodiversity of microalgae and their adaptation to a wide range of changing environments has resulted in them containing unique suites of compounds. Certain suites of compounds play a key role in protecting the cell against for example the sun's damaging rays. These same compounds have potential to protect humans and could be used in a range of healthcare consumer products. Currently, microalgae are a relatively untapped source of natural products. The heathcare industry are are looking to nature for sustainable alternatives in a range of their personal care products and microalgae have many attributes that make them particularly attractive. Research at Plymouth Marine Laboratory in collaboration with the Boots Company has revealed that certain species of microalgae contain valuable bioactivity including sunscreen protection and antioxidant activity. This project will focus on optimising the yield of these bioactives and on understanding biosynthetic pathways and interconversions. Results from experimental studies will be compared to those derived from mathematical models and will be used to optimise the yield of bioactives in microalgae grown using photobioreactor (PBR) technology, required for commercial scale production of microlagae. We will also investigate the potential of using waste CO2 and NOx emissions to enhance the growth of the microalgae and assess the impact this has on levels of bioactives. Additionally co-product material, remaining after extraction of targeted bioactives, will be investigated as a potential sustainable source of nutrition for farmed fish.

微藻，一种遍布于世界海洋的微型植物，是大自然自身的能量电池，它将太阳的光能转化为化合物。微藻的高度生物多样性及其对广泛变化的环境的适应性导致它们含有独特的化合物套件。某些化合物在保护细胞免受太阳等有害射线的侵害方面发挥着关键作用。这些化合物具有保护人类的潜力，可用于一系列医疗保健消费品。目前，微藻是相对未开发的天然产品来源。保健行业正在寻找自然界的可持续替代品在一系列的个人护理产品和微藻有许多属性，使他们特别有吸引力。普利茅斯海洋实验室与Boots公司合作的研究表明，某些种类的微藻含有宝贵的生物活性，包括防晒保护和抗氧化活性。该项目将专注于优化这些生物活性物质的产量，并了解生物合成途径和相互转化。实验研究的结果将与数学模型的结果进行比较，并将用于优化微藻商业规模生产所需的光生物反应器（PBR）技术生长的微藻中生物活性物质的产量。我们还将研究利用废弃的二氧化碳和氮氧化物排放来促进微藻生长的潜力，并评估这对生物活性物质水平的影响。此外，将研究提取目标生物活性物质后剩余的副产品材料，作为养殖鱼类潜在的可持续营养来源。