NASA BED REST PROJECT CAMPAIGN 1: IMMUNE FUNCTION AND STERIODOGENESIS

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。背景：太空飞行似乎会降低宇航员抵抗感染的能力，并使他们变得虚弱。美国宇航局的科学家们正在努力让宇航员在太空中度过很长一段时间时变得更健康、更安全。头朝下卧床休息是假装一个人在没有重力的太空中旅行的好方法。这项研究将显示你的身体（头朝下、脚朝上）有多像宇航员的身体。 具体目标和程序（摘要）：卧床休息研究的目的是开始获取有关人们的信息，以便科学家能够为太空飞行对宇航员健康造成的不良后果改善方法。科学家们希望开发出一种药物、锻炼计划或任何能够减少宇航员在太空飞行期间发生的不良变化以及损害他们返回地球后正常活动的任何东西。 实验设计（摘要）：志愿者将在加尔维斯顿的医院住84天。其中 60 天他们将卧床休息。除了卧床休息外，这些研究还将进行心理和身体测试，称为综合测试方案（ITR）。这些测试测量卧床休息之前、期间和之后身体和精神的变化。目前，许多此类测试是在宇航员太空飞行前后进行的，以观察长途太空旅行后的变化。 意义（摘要）：本研究中收集的信息将有助于规划未来的太空飞行并找到保持免疫系统健康的方法

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Space flight seems to lower an astronaut's ability to fight off infection and makes them weak. NASA scientists are working to make astronauts healthier and safer when they spend a long time in space. Head-down bed rest is a good way to pretend a person is traveling in space without gravity. This study will show how much your body, tilted head down and feet up, is like an astronaut's body. Specific Aims and Procedures (summary): The reason for the bed rest study is to begin getting information on people so that scientists can make ways for the bad results of space flight on astronaut's health to be better. The scientists hope to make a drug, exercise program or anything that will lower the bad changes that happen to astronauts during space flight and that hurt their normal activities after they return to Earth. Experimental Design (summary): Volunteers will live at the hospital in Galveston for 84-days. They will stay in bed for 60 of those days. Along with bed rest, these studies will have mental and physical tests called the Integrated Testing Regimen (ITR). These tests measure changes in your body and mind before, during and after bed rest. Right now, many of these tests are used on astronauts before and after space flight to watch the changes from long trips into space. Significance (summary): The information collected in this study will help plan future space flights and make a way to keep the immune system healthy