NASA FLIGHT ANALOGS/BED REST RESEARCH PROJECT CAMPAIGN 5

NASA 飞行模拟/卧床休息研究项目活动 5

• 批准号: 7719190
• 负责人: DAVID L WARE
• 金额: $ 160.32万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719190
• 关键词: Astronauts; Bed rest; Beds; Computer Retrieval of Information on Scientific Projects Database; Equilibrium; Experimental Designs; Force of Gravity; Funding; Future; Grant; Head; Hospitals; Immune; Institution; Investigation; Learning; Living Wills; Measures; Mechanics; Muscle; Nervous system structure; Persons; Procedures; Psyche structure; Research; Research Personnel; Research Project Grants; Resources; Scientist; Source; Space Flight; Stimulus; Study Subject; Testing; Time; Travel; United States National Aeronautics and Space Administration; United States National Institutes of Health; Work; analog; body-mind; bone; bone quality; day; foot; heart circulation; muscle strength; nutrition; prevent; vibration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: NASA scientists are working to find ways to keep astronauts healthier and safer when they spend a long time in space. Head down bed rest is a good way to mimic a person traveling in space without gravity. Head-down bed rest helps researchers study people on earth in a way that causes some of the changes the body goes through while traveling in space without gravity. NASA has developed a long term plan for using bed rest studies to help find ways to prevent some of these changes. This investigation, referred to as Campaign 5, is the next part of that long term plan. In this study scientists will test the use of a mildly vibrating platform to preserve bone quality, muscle strength, and balance during head down bed rest. Scientists refer to this vibration as "Low Magnitude Mechanical Stimuli" or LMMS. Hypothesis: Ten minutes per day of LMMS will stop the changes to bone, muscle, and balance that are caused by bed rest. Specific Aims and Procedures (summary): In order to learn as much as possible during the study, the scientists will measure changes in bone, muscle, heart, circulation, and nervous system, as well as nutrition and immune status. They will use tests that they have developed over many years for evaluating astronauts, and some specialized tests to see if LMMS helps stop these changes. Experimental Design (summary): During the study subjects will live at the special research unit at the hospital in Galveston for 115 to 119 days. They will stay in bed with their head tilted downward for 90 of those days. Along with bed rest, they will have mental and physical testing to measure changes in their body and mind before, during and after bed rest. Every day during the bed rest part of this study subjects will undergo a ten minute vibration procedure. While they are lying in bed the subjects will be held in place with their feet against a mildly vibrating plate by springs attached to a vest that the subject will wear. Significance (summary): Scientists hope to get information that will help keep astronauts healthy on future space flights.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 背景资料： 美国宇航局的科学家们正在努力寻找方法，使宇航员在太空中度过长时间时保持健康和安全。头朝下卧床休息是一个很好的方式来模仿一个人在太空旅行没有重力。 头朝下卧床休息有助于研究人员研究地球上的人，这种方式会导致身体在没有重力的太空旅行中经历的一些变化。 美国宇航局已经制定了一项长期计划，利用卧床休息研究来帮助找到防止这些变化的方法。这项调查，被称为活动5，是该长期计划的下一部分。在这项研究中，科学家们将测试使用一个温和的振动平台，以保持骨骼质量，肌肉力量和平衡，在头向下卧床休息。科学家将这种振动称为“低强度机械刺激”或LMMS。 假设： 每天10分钟的LMMS将停止由卧床休息引起的骨骼，肌肉和平衡的变化。 具体目标和程序（摘要）： 为了在研究过程中尽可能多地了解情况，科学家们将测量骨骼、肌肉、心脏、循环和神经系统的变化，以及营养和免疫状态。他们将使用他们多年来开发的测试来评估宇航员，以及一些专门的测试来看看LMMS是否有助于阻止这些变化。 实验设计（总结）： 在研究期间，受试者将在加尔维斯顿医院的特别研究单位生活115至119天。 他们会在床上躺90天，头向下倾斜。 沿着卧床休息，他们将进行精神和身体测试，以测量他们在卧床休息前、期间和之后的身心变化。 在本研究的卧床休息部分，受试者每天将接受10分钟的振动程序。 当他们躺在床上时，受试者将被固定在适当的位置，他们的脚靠在一个温和振动的板上，弹簧连接到受试者将穿的背心上。 意义（总结）： 科学家们希望获得有助于在未来的太空飞行中保持宇航员健康的信息。