NASA FLIGHT ANALOGS/BED REST RESEARCH PROJECT CAMPAIGN 5

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景： 美国国家航空航天局的科学家们正在努力寻找方法，让宇航员在长时间呆在太空时更健康、更安全。头朝下卧床休息是模仿一个人在没有重力的情况下在太空旅行的好方法。头朝下卧床休息有助于研究人员研究地球上的人，这种方式会导致身体在没有重力的情况下在太空旅行时所经历的一些变化。 NASA已经制定了一项长期计划，利用卧床休息研究来帮助找到防止其中一些变化的方法。这项调查被称为第五次竞选，是这项长期计划的下一部分。在这项研究中，科学家们将测试使用温和的振动平台来保持骨骼质量、肌肉力量和头朝下卧床时的平衡。科学家将这种振动称为“低强度机械刺激”或LMM。 假设： 每天10分钟的LMMS运动将阻止卧床休息对骨骼、肌肉和平衡造成的变化。 具体目标和程序(摘要)： 为了在研究中尽可能多地了解情况，科学家们将测量骨骼、肌肉、心脏、循环和神经系统的变化，以及营养和免疫状态。他们将使用多年来开发的测试来评估宇航员，以及一些专门的测试，看看LMM是否有助于阻止这些变化。 实验设计(摘要)： 在研究期间，受试者将在加尔维斯顿医院的特殊研究单元生活115至119天。他们将在90天的时间里头朝下地躺在床上。除了卧床休息外，他们还将接受精神和身体测试，以衡量他们在卧床前、卧床期间和卧床后身体和精神的变化。 在这项研究中，受试者每天在卧床休息时都会经历10分钟的振动过程。当他们躺在床上时，受试者的脚将被固定在一个轻微振动的盘子上，弹簧连接到受试者穿的背心上。 意义(摘要)： 科学家们希望获得有助于宇航员在未来的太空飞行中保持健康的信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: NASA scientists are working to find ways to keep astronauts healthier and safer when they spend a long time in space. Head down bed rest is a good way to mimic a person traveling in space without gravity. Head-down bed rest helps researchers study people on earth in a way that causes some of the changes the body goes through while traveling in space without gravity. NASA has developed a long term plan for using bed rest studies to help find ways to prevent some of these changes. This investigation, referred to as Campaign 5, is the next part of that long term plan. In this study scientists will test the use of a mildly vibrating platform to preserve bone quality, muscle strength, and balance during head down bed rest. Scientists refer to this vibration as "Low Magnitude Mechanical Stimuli" or LMMS. Hypothesis: Ten minutes per day of LMMS will stop the changes to bone, muscle, and balance that are caused by bed rest. Specific Aims and Procedures (summary): In order to learn as much as possible during the study, the scientists will measure changes in bone, muscle, heart, circulation, and nervous system, as well as nutrition and immune status. They will use tests that they have developed over many years for evaluating astronauts, and some specialized tests to see if LMMS helps stop these changes. Experimental Design (summary): During the study subjects will live at the special research unit at the hospital in Galveston for 115 to 119 days. They will stay in bed with their head tilted downward for 90 of those days. Along with bed rest, they will have mental and physical testing to measure changes in their body and mind before, during and after bed rest. Every day during the bed rest part of this study subjects will undergo a ten minute vibration procedure. While they are lying in bed the subjects will be held in place with their feet against a mildly vibrating plate by springs attached to a vest that the subject will wear. Significance (summary): Scientists hope to get information that will help keep astronauts healthy on future space flights.