NASA FLIGHT ANALOGS/BED REST RESEARCH PROJECT CAMPAIGN 5

NASA 飞行模拟/卧床休息研究项目活动 5

• 批准号: 7605421
• 负责人: DAVID L WARE
• 金额: $ 156.42万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605421
• 关键词: Astronauts; Bed rest; Beds; Computer Retrieval of Information on Scientific Projects Database; Equilibrium; Experimental Designs; Force of Gravity; Funding; Future; Grant; Head; Hospitals; Immune; Institution; Investigation; Learning; Living Wills; Measures; Mechanics; Muscle; Nervous system structure; Persons; Procedures; Psyche structure; Research; Research Personnel; Research Project Grants; Resources; Scientist; Source; Space Flight; Stimulus; Study Subject; Testing; Time; Travel; United States National Aeronautics and Space Administration; United States National Institutes of Health; Work; analog; body-mind; bone; bone quality; day; foot; heart circulation; muscle strength; nutrition; prevent; vibration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: NASA scientists are working to find ways to keep astronauts healthier and safer when they spend a long time in space. Head down bed rest is a good way to mimic a person traveling in space without gravity. Head-down bed rest helps researchers study people on earth in a way that causes some of the changes the body goes through while traveling in space without gravity. NASA has developed a long term plan for using bed rest studies to help find ways to prevent some of these changes. This investigation, referred to as Campaign 5, is the next part of that long term plan. In this study scientists will test the use of a mildly vibrating platform to preserve bone quality, muscle strength, and balance during head down bed rest. Scientists refer to this vibration as "Low Magnitude Mechanical Stimuli" or LMMS. Hypothesis: Ten minutes per day of LMMS will stop the changes to bone, muscle, and balance that are caused by bed rest. Specific Aims and Procedures (summary): In order to learn as much as possible during the study, the scientists will measure changes in bone, muscle, heart, circulation, and nervous system, as well as nutrition and immune status. They will use tests that they have developed over many years for evaluating astronauts, and some specialized tests to see if LMMS helps stop these changes. Experimental Design (summary): During the study subjects will live at the special research unit at the hospital in Galveston for 115 to 119 days. They will stay in bed with their head tilted downward for 90 of those days. Along with bed rest, they will have mental and physical testing to measure changes in their body and mind before, during and after bed rest. Every day during the bed rest part of this study subjects will undergo a ten minute vibration procedure. While they are lying in bed the subjects will be held in place with their feet against a mildly vibrating plate by springs attached to a vest that the subject will wear. Significance (summary): Scientists hope to get information that will help keep astronauts healthy on future space flights.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 背景： 美国宇航局的科学家们正在努力寻找方法，让宇航员在长时间在太空中时保持健康和安全。头朝下卧床休息是模仿人在无重力的太空中旅行的好方法。 低头卧床休息有助于研究人员研究地球上的人，这种方式会导致身体在无重力的太空旅行时经历一些变化。 美国国家航空航天局 (NASA) 制定了一项长期计划，利用卧床休息研究来帮助找到预防这些变化的方法。这项调查被称为“行动 5”，是该长期计划的下一部分。在这项研究中，科学家们将测试使用轻微振动平台在低头卧床休息期间保持骨骼质量、肌肉力量和平衡。科学家将这种振动称为“低强度机械刺激”或 LMMS。 假设： 每天 10 分钟的 LMMS 将阻止卧床休息引起的骨骼、肌肉和平衡的变化。 具体目标和程序（摘要）： 为了在研究过程中尽可能多地了解情况，科学家们将测量骨骼、肌肉、心脏、循环和神经系统以及营养和免疫状态的变化。他们将使用多年来开发的用于评估宇航员的测试，以及一些专门的测试来看看 LMMS 是否有助于阻止这些变化。 实验设计（摘要）： 研究期间，受试者将在加尔维斯顿医院的特别研究室居住 115 至 119 天。 其中 90 天，他们会低着头躺在床上。 除了卧床休息外，他们还将接受精神和身体测试，以测量卧床休息之前、期间和之后身体和精神的变化。 每天在卧床休息期间，该研究对象的一部分将接受十分钟的振动程序。 当受试者躺在床上时，他们的脚将被固定在受试者将穿的背心上的弹簧固定在轻微振动的板上。 意义（概要）： 科学家希望获得有助于宇航员在未来太空飞行中保持健康的信息。