NASA FLIGHT ANALOGS/BED REST RESEARCH PROJECT CAMPAIGN 5

NASA 飞行模拟/卧床休息研究项目活动 5

• 批准号: 7605421
• 负责人: DAVID L WARE
• 金额: $ 156.42万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605421
• 关键词: Astronauts; Bed rest; Beds; Computer Retrieval of Information on Scientific Projects Database; Equilibrium; Experimental Designs; Force of Gravity; Funding; Future; Grant; Head; Hospitals; Immune; Institution; Investigation; Learning; Living Wills; Measures; Mechanics; Muscle; Nervous system structure; Persons; Procedures; Psyche structure; Research; Research Personnel; Research Project Grants; Resources; Scientist; Source; Space Flight; Stimulus; Study Subject; Testing; Time; Travel; United States National Aeronautics and Space Administration; United States National Institutes of Health; Work; analog; body-mind; bone; bone quality; day; foot; heart circulation; muscle strength; nutrition; prevent; vibration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: NASA scientists are working to find ways to keep astronauts healthier and safer when they spend a long time in space. Head down bed rest is a good way to mimic a person traveling in space without gravity. Head-down bed rest helps researchers study people on earth in a way that causes some of the changes the body goes through while traveling in space without gravity. NASA has developed a long term plan for using bed rest studies to help find ways to prevent some of these changes. This investigation, referred to as Campaign 5, is the next part of that long term plan. In this study scientists will test the use of a mildly vibrating platform to preserve bone quality, muscle strength, and balance during head down bed rest. Scientists refer to this vibration as "Low Magnitude Mechanical Stimuli" or LMMS. Hypothesis: Ten minutes per day of LMMS will stop the changes to bone, muscle, and balance that are caused by bed rest. Specific Aims and Procedures (summary): In order to learn as much as possible during the study, the scientists will measure changes in bone, muscle, heart, circulation, and nervous system, as well as nutrition and immune status. They will use tests that they have developed over many years for evaluating astronauts, and some specialized tests to see if LMMS helps stop these changes. Experimental Design (summary): During the study subjects will live at the special research unit at the hospital in Galveston for 115 to 119 days. They will stay in bed with their head tilted downward for 90 of those days. Along with bed rest, they will have mental and physical testing to measure changes in their body and mind before, during and after bed rest. Every day during the bed rest part of this study subjects will undergo a ten minute vibration procedure. While they are lying in bed the subjects will be held in place with their feet against a mildly vibrating plate by springs attached to a vest that the subject will wear. Significance (summary): Scientists hope to get information that will help keep astronauts healthy on future space flights.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 背景： NASA科学家正在努力寻找方法，以使宇航员在太空中花费很长时间时更健康，更安全。躺下床休息是模仿无重力旅行的人的好方法。 头向下的床休息可以帮助研究人员以一种导致人体在没有重力的太空旅行时进行的一些变化的方式研究人。 NASA已制定了一项长期计划，用于使用床休息研究，以帮助找到防止其中一些变化的方法。这项调查（称为竞选5）是长期计划的下一部分。在这项研究中，科学家将测试使用轻度振动平台，以保持骨骼质量，肌肉力量和在床下休息期间的平衡。科学家将这种振动称为“低幅度机械刺激”或LMM。 假设： 每天十分钟的LMM会阻止床休息引起的骨骼，肌肉和平衡的变化。 具体目标和程序（摘要）： 为了在研究期间尽可能多地学习，科学家将衡量骨骼，肌肉，心脏，循环和神经系统的变化以及营养和免疫状态。他们将使用他们多年来开发的测试来评估宇航员，并进行一些专门测试，以查看LMM是否有助于阻止这些变化。 实验设计（摘要）： 在研究期间，受试者将在加尔维斯顿医院的特别研究部门生活115至119天。 他们将在那几天的90天倾斜的头部躺在床上。 随着床休息，他们将进行精神和身体测试，以测量床休息之前，之中和之后的身心变化。 床休息的每一天，本研究对象都会进行十分钟的振动程序。 当他们躺在床上时，受试者的脚将被固定在适当的振动板上，该弹簧附着在受试者会佩戴的背心上。 意义（摘要）： 科学家希望获得信息，以帮助使宇航员在未来的太空航班上保持健康。