ELECTRICAL STIMULATION FOR UPPER LIMB RECOVERY IN STROKE

中风时上肢恢复的电刺激

• 批准号: 7378026
• 负责人: John Chae
• 金额: $ 0.22万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378026
• 关键词: ELECTRICAL; STIMULATION; UPPER; LIMB; RECOVERY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a two center, single-blinded randomized clinical trial. A total of 189 stroke survivors within 3 months of their stroke will be enrolled and randomized to one of three groups: 1) cyclic neuromuscular electrical stimulation (NMES), 2) EMG-triggered NMES, and 3) cyclic sensory stimulation. Cyclic NMES will provide repetitive wrist and finger extension without input from the subject, EMG-triggered NMES will provide repetitive wrist and finger extension in response to volitionally activated EMG signal from the paretic wrist extensor, and sensory stimulation will provide repetitive sensory stimulation without motor activation. All subjects will be treated for 80 minutes per day, 5 days per week, for 8 weeks. Initial training will be provided on the inpatient stroke rehabilitation unit and then treatments will be completed at home. Blinded assessments of motor impairment (Fugl-Meyer Motor Assessment) and activity limitation (Arm Motor Ability Test) will be administered at baseline, mid-treatment, end of treatment, and at 1, 3, and 6 months after completion of treatment.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项双中心、单盲、随机临床试验。共189例卒中3个月内的卒中幸存者将入组并随机分配至三组之一：1）周期性神经肌肉电刺激（NMES），2）EMG触发的NMES，3）周期性感觉刺激。循环NMES将在没有来自受试者的输入的情况下提供重复的手腕和手指伸展，EMG触发的NMES将响应于来自麻痹手腕伸肌的意志激活的EMG信号而提供重复的手腕和手指伸展，并且感觉刺激将在没有运动激活的情况下提供重复的感觉刺激。所有受试者将接受每天80分钟的治疗，每周5天，持续8周。初步培训将在住院中风康复单位提供，然后治疗将在家里完成。将在基线、治疗中期、治疗结束时以及治疗完成后1、3和6个月进行运动障碍（Fugl-Meyer运动评估）和活动受限（手臂运动能力测试）的盲态评估。