ELECTRICAL STIMULATION FOR UPPER LIMB RECOVERY IN STROKE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一个双中心，单盲随机临床试验。共有189名中风幸存者在中风后3个月内被纳入研究，并随机分为三组：1)循环神经肌肉电刺激（NMES）， 2)肌电触发NMES， 3)循环感觉刺激。循环NMES将在没有受试者输入的情况下提供重复的手腕和手指伸展，肌电信号触发的NMES将根据麻痹的手腕伸肌的意志激活的肌电信号提供重复的手腕和手指伸展，感觉刺激将在没有运动激活的情况下提供重复的感觉刺激。所有受试者每天治疗80分钟，每周5天，共8周。最初的培训将在住院中风康复病房进行，然后在家中完成治疗。运动障碍（Fugl-Meyer运动评估）和活动限制（手臂运动能力测试）的盲法评估将在基线、治疗中期、治疗结束以及治疗完成后的1、3和6个月进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a two center, single-blinded randomized clinical trial. A total of 189 stroke survivors within 3 months of their stroke will be enrolled and randomized to one of three groups: 1) cyclic neuromuscular electrical stimulation (NMES), 2) EMG-triggered NMES, and 3) cyclic sensory stimulation. Cyclic NMES will provide repetitive wrist and finger extension without input from the subject, EMG-triggered NMES will provide repetitive wrist and finger extension in response to volitionally activated EMG signal from the paretic wrist extensor, and sensory stimulation will provide repetitive sensory stimulation without motor activation. All subjects will be treated for 80 minutes per day, 5 days per week, for 8 weeks. Initial training will be provided on the inpatient stroke rehabilitation unit and then treatments will be completed at home. Blinded assessments of motor impairment (Fugl-Meyer Motor Assessment) and activity limitation (Arm Motor Ability Test) will be administered at baseline, mid-treatment, end of treatment, and at 1, 3, and 6 months after completion of treatment.