ELECTRICAL STIMULATION FOR UPPER LIMB RECOVERY IN STROKE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这是一项双中心、单盲、随机的临床试验。189名中风后3个月内的幸存者将被纳入并随机分为三组：1)循环神经肌肉电刺激(NMES)组，2)肌电触发NMES组，和3)循环感觉刺激组。循环NMES将提供重复的手腕和手指伸展，而不需要受试者的输入，EMG触发的NMES将响应来自偏瘫腕伸肌的自愿激活的EMG信号提供重复的手腕和手指伸展，而感觉刺激将提供重复的感觉刺激，而不需要运动激活。所有受试者将接受为期8周的治疗，每天80分钟，每周5天。将在住院中风康复室提供初步培训，然后在家中完成治疗。运动障碍的盲法评估(Fugl-Meyer运动评估)和活动限制(手臂运动能力测试)将在基线、治疗中期、治疗结束时以及治疗完成后1、3和6个月进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a two center, single-blinded randomized clinical trial. A total of 189 stroke survivors within 3 months of their stroke will be enrolled and randomized to one of three groups: 1) cyclic neuromuscular electrical stimulation (NMES), 2) EMG-triggered NMES, and 3) cyclic sensory stimulation. Cyclic NMES will provide repetitive wrist and finger extension without input from the subject, EMG-triggered NMES will provide repetitive wrist and finger extension in response to volitionally activated EMG signal from the paretic wrist extensor, and sensory stimulation will provide repetitive sensory stimulation without motor activation. All subjects will be treated for 80 minutes per day, 5 days per week, for 8 weeks. Initial training will be provided on the inpatient stroke rehabilitation unit and then treatments will be completed at home. Blinded assessments of motor impairment (Fugl-Meyer Motor Assessment) and activity limitation (Arm Motor Ability Test) will be administered at baseline, mid-treatment, end of treatment, and at 1, 3, and 6 months after completion of treatment.