MECHANISMS OF MUSCLE PROTEIN LOSS AFTER HIP SURGERY/HIP FRACTURE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。背景：髋关节手术后的肌肉损失需要更长的康复期，并推迟重返工作岗位。假设：减少身体的压力，增加其制造蛋白质的能力，将减少髋关节手术后的肌肉损失，有助于康复。具体目标和程序(摘要)：我们将研究髋关节手术后和出院前身体和肌肉如何产生蛋白质。此外，我们将测试营养补充剂和普通药物对这些过程的影响。实验设计(总结)：本研究将有5组随机分配的患者。第一组作为正常对照组，术前只做一次检查。第2-5组将在髋关节置换术后立即进行研究(在手术恢复期间)，并在手术干预后出院前再次进行研究。这些组包括安慰剂(第2组)、氨基酸(AA)补充剂(第3组)、酮康唑给药(第4组)，以及同时接受酮康唑和AA的联合组(第5组)。意义(摘要)：减少术后肌肉损失将有助于恢复和恢复正常功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Muscle loss after hip surgery requires a longer period of rehabilitation and delays the return to work. Hypothesis: Reducing the body's stress and increasing its ability to make protein will decrease muscle loss after hip surgery and help rehabilitation. Specific Aims and Procedures (summary): We will study how the body and muscle make protein after hip surgery and before discharge from the hospital. Further, we will test the effects of a nutritional supplement and a common drug on these processes. Experimental Design (summary): This study will have 5 groups of randomly assigned patients. Group 1 will serve as a normal control group and be studied only once before surgery. Groups 2-5 will be studied immediately after hip arthroplasty (during surgical recovery) and again prior to discharge from the hospital after surgical intervention. These groups include placebo (Group 2), amino acid (AA) supplementation (Group 3), ketoconazole administration (Group 4), and a combined group to receive both ketoconazole and AA (Group 5). Significance (summary): Reducing the loss of muscle after surgery will help with recovery and return to normal function.