COMBINED EFFECTS OF NUTRITIONAL AND EXERCISE COUNTERMEASURES

营养和运动对策的综合作用

• 批准号: 7605398
• 负责人: ARNY A FERRANDO
• 金额: $ 5.28万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605398
• 关键词: Age; Amino Acids; Astronauts; Bed rest; Blood; Calories; Computer Retrieval of Information on Scientific Projects Database; Condition; Consent Forms; Daily; Diet; Exercise; Experimental Designs; Funding; Grant; Hormones; Hour; Hydrocortisone; Institution; Life; Muscle; Muscle Proteins; Muscle function; Nutritional; Patients; Procedures; Randomized; Research; Research Personnel; Resistance; Resources; Screening procedure; Simulate; Source; Space Flight; Stress; Supplementation; Training; United States National Institutes of Health; Visit; Week; Weight; day; experience; follow-up; member; metabolic abnormality assessment; nutrition; protein metabolism; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: This experiment will simulate many of the physical conditions experienced by astronauts during spaceflight by examining the effects of resistance exercise (weight training), nutrition and a stress hormone (cortisol) on muscle during 28 days of bedrest. Specific Aims and Procedures (summary): To determine if a combination of resistance exercise and amino acid supplementation can reduce muscle loss and maintain muscle function during 28 days of bedrest by mimicking the diet of astronauts during spaceflight by providing approximately 80% of the calories normally ingested during daily life. Experimental Design (summary): This study will include normal healthy subjects between the ages of 18-50. Subjects will undergo a comprehensive screening visit prior to participating and will be assessed by multiple members of the research team. The study involves a 36-day in-patient stay in the GCRC with two nine hour metabolic studies. The metabolic studies will take place on days 6 and 34 of bedrest. Cortisol will be administered throughout the 28 day bedrest portion of the study to increase blood cortisol levels to those experienced in spaceflight. Subjects will be randomly assigned to one of six experimental conditions (please refer to page 2 of the consent form). Subjects will be required to return to the GCRC for three additional 30 minute follow-up visits two weeks following the study. Significance (summary): Information derived from these studies will allow a better understanding of the mechanisms involved in the response of muscle protein metabolism to exercise, inactivity, and nutrition.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 背景：该实验将模拟宇航员在太空飞行期间经历的许多身体状况，通过检查 28 天卧床休息期间抗阻运动（重量训练）、营养和应激激素（皮质醇）对肌肉的影响。 具体目标和程序（摘要）：通过模仿宇航员在太空飞行期间的饮食，提供日常生活中正常摄入的约 80% 的卡路里，确定抗阻运动和氨基酸补充相结合是否可以减少肌肉损失并在 28 天卧床休息期间维持肌肉功能。 实验设计（摘要）：本研究将包括 18-50 岁之间的正常健康受试者。受试者在参与之前将接受全面的筛选访问，并将由研究团队的多名成员进行评估。该研究包括在 GCRC 中进行 36 天的住院治疗，并进行两项 9 小时的代谢研究。代谢研究将在卧床休息的第 6 天和第 34 天进行。在该研究的 28 天卧床休息部分中，将注射皮质醇，以提高那些经历过太空飞行的人的血液皮质醇水平。受试者将被随机分配到六种实验条件之一（请参阅同意书的第 2 页）。研究两周后，受试者将被要求返回 GCRC 进行另外 3 次 30 分钟的随访。 意义（摘要）：从这些研究中获得的信息将有助于更好地理解肌肉蛋白质代谢对运动、不活动和营养的反应所涉及的机制。