AMINO ACID SUPPPLEMENTATION AND MUSCLE

氨基酸补充和肌肉

• 批准号: 7431658
• 负责人: ARNY A FERRANDO
• 金额: $ 26.16万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7431658
• 关键词: Amino Acids; Bed rest; Caring; Daily; Elderly; Essential Amino Acids; Exercise; Goals; Individual; Injury; Intervention; Investigation; Morbidity - disease rate; Muscle; Muscle Proteins; Muscle function; Nutritional; Operative Surgical Procedures; Orthopedic Surgery procedures; Orthopedics; Prevalence; Protein Biosynthesis; Recovery; Resistance; Risk; Standards of Weights and Measures; Stress; Supplementation; Testing; Time; Treatment Protocols; Walking; Woman; day; mortality; older men; protein metabolism; wasting

Muscle wasting and weakness are prevalent after forced inactivity and bedrest. Unfortunately, bedrest is an inherent aspect of recovery from major orthopedic surgery, serious injury, or prolonged illness. The inherent loss of lean body mass (LBM) with inactivity is associated with increased recovery time and increased morbidity. Due to the greater prevalence of major orthopedic operations and serious illness, older individuals are at an increased risk for morbidity and mortality associated with extended periods of forced inactivity when combined with these stresses. Our previous investigations in younger individuals demonstrated that minimal resistance exercise and nutritional supplementation with essential amino acids (EAA) can maintain LBM and preserve or diminish the loss of muscle function. Therefore, the goal of this project is to examine the effects of EAA alone or in combination with resistance or walking exercise on muscle protein metabolism, LBM, and muscle function in older individuals. We propose to study three groups of older men and women (65-80 years) before, during, and after 10 days of bedrest: 1) a group who will receive three supplements per day of EAA alone (EAA), 2) a group that will receive the same EAA supplementation plus three sessions of resistance exercise throughout bedrest (EAA+RE), and 3) a group who will receive EAA supplementation plus the standard-of-care daily walking exercise (EAA+WE). The effects of RE and WE alone will be tested by Dr. Trappe at UAMS; however, we will examine the hypotheses that the combination of EAA and these exercise regimens will be more effective in preserving muscle protein synthesis, LBM, and muscle function than either intervention alone. Further, we propose that combination of these interventions will expedite recovery from bedrest. Finally, we propose that these interventions, or combination of interventions, will be effective in maintaining muscle protein synthesis, muscle mass, and function in the elderly.

被迫不活动和卧床休息后，肌肉萎缩和无力很常见。不幸的是，卧床休息是从大型骨科手术、严重受伤或长期疾病中恢复的一个固有方面。不活动导致的去脂体重 (LBM) 固有损失与恢复时间增加和发病率增加有关。由于大型骨科手术和严重疾病的流行，老年人因长时间被迫不活动而面临这些压力，因此发病和死亡的风险增加。我们之前对年轻人的研究表明，最小限度的阻力运动和补充必需氨基酸（EAA）营养可以维持 LBM 并保持或减少肌肉功能的丧失。因此，该项目的目标是检查 EAA 单独使用或与阻力或步行锻炼相结合对老年人肌肉蛋白代谢、LBM 和肌肉功能的影响。我们建议在卧床休息 10 天之前、期间和之后对三组老年男性和女性（65-80 岁）进行研究：1) 一组每天仅接受 3 次 EAA 补充剂 (EAA)；2) 一组接受相同的 EAA 补充剂加上整个卧床期间的 3 次阻力运动 (EAA+RE)；3) 一组接受 EAA 补充剂加上标准护理每日步行锻炼 (EAA+WE)。 UAMS 的 Trappe 博士将单独测试 RE 和 WE 的效果；然而，我们将检验以下假设：EAA 与这些运动方案相结合，比单独使用任何一种干预措施更能有效地保护肌肉蛋白质合成、LBM 和肌肉功能。此外，我们建议结合这些干预措施将加速卧床恢复。最后，我们建议这些干预措施或干预措施的组合将有效维持老年人的肌肉蛋白质合成、肌肉质量和功能。