AMINO ACID SUPPPLEMENTATION AND MUSCLE

肌肉萎缩和虚弱是普遍的强迫活动和卧床休息后。不幸的是，卧床休息是一个固有的方面，从重大骨科手术，严重受伤，或长期疾病的恢复。不活动时瘦体重（LBM）的固有损失与恢复时间增加和发病率增加有关。由于主要的整形手术和严重疾病的发病率更高，老年人的发病率和死亡率的风险增加，与长期强迫不活动相结合时，这些压力。我们之前对年轻人的研究表明，最小阻力运动和补充必需氨基酸（EAA）的营养可以维持LBM并保持或减少肌肉功能的丧失。因此，本项目的目标是研究EAA单独或与阻力或步行运动相结合对老年人肌肉蛋白质代谢，LBM和肌肉功能的影响。我们建议研究三组老年男女（65-80岁）在卧床休息10天之前、期间和之后：1）每天仅接受三次EAA补充剂（EAA）的组，2）在整个卧床期间接受相同EAA补充剂加上三次阻力运动的组（EAA+RE），以及3）将接受EAA补充剂加标准护理每日步行锻炼（EAA+WE）的组。Trappe博士将在UAMS测试RE和WE单独的效果;然而，我们将研究EAA和这些运动方案的组合在保护肌肉蛋白质合成，LBM和肌肉功能方面比单独干预更有效的假设。此外，我们建议这些干预措施的结合将加快从卧床休息中恢复。最后，我们建议这些干预措施或干预措施的组合将有效地维持老年人的肌肉蛋白质合成，肌肉质量和功能。

Muscle wasting and weakness are prevalent after forced inactivity and bedrest. Unfortunately, bedrest is an inherent aspect of recovery from major orthopedic surgery, serious injury, or prolonged illness. The inherent loss of lean body mass (LBM) with inactivity is associated with increased recovery time and increased morbidity. Due to the greater prevalence of major orthopedic operations and serious illness, older individuals are at an increased risk for morbidity and mortality associated with extended periods of forced inactivity when combined with these stresses. Our previous investigations in younger individuals demonstrated that minimal resistance exercise and nutritional supplementation with essential amino acids (EAA) can maintain LBM and preserve or diminish the loss of muscle function. Therefore, the goal of this project is to examine the effects of EAA alone or in combination with resistance or walking exercise on muscle protein metabolism, LBM, and muscle function in older individuals. We propose to study three groups of older men and women (65-80 years) before, during, and after 10 days of bedrest: 1) a group who will receive three supplements per day of EAA alone (EAA), 2) a group that will receive the same EAA supplementation plus three sessions of resistance exercise throughout bedrest (EAA+RE), and 3) a group who will receive EAA supplementation plus the standard-of-care daily walking exercise (EAA+WE). The effects of RE and WE alone will be tested by Dr. Trappe at UAMS; however, we will examine the hypotheses that the combination of EAA and these exercise regimens will be more effective in preserving muscle protein synthesis, LBM, and muscle function than either intervention alone. Further, we propose that combination of these interventions will expedite recovery from bedrest. Finally, we propose that these interventions, or combination of interventions, will be effective in maintaining muscle protein synthesis, muscle mass, and function in the elderly.