MECHANISMS OF MUSCLE PROTEIN LOSS AFTER HIP SURGERY/HIP FRACTURE

髋关节手术/髋部骨折后肌肉蛋白丢失的机制

• 批准号: 7605404
• 负责人: ARNY A FERRANDO
• 金额: $ 0.61万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605404
• 关键词: Amino Acids; Arthroplasty; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Experimental Designs; Funding; Grant; Hip Fractures; Hip region structure; Hospitals; Institution; Ketoconazole; Muscle; Muscle Proteins; Operative Surgical Procedures; Patients; Pharmaceutical Preparations; Placebos; Procedures; Process; Proteins; Randomized; Recovery; Rehabilitation therapy; Research; Research Personnel; Resources; Source; Stress; Supplementation; Testing; United States National Institutes of Health; Work; dietary supplements; hip surgery

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Muscle loss after hip surgery requires a longer period of rehabilitation and delays the return to work. Hypothesis: Reducing the body's stress and increasing its ability to make protein will decrease muscle loss after hip surgery and help rehabilitation. Specific Aims and Procedures (summary): We will study how the body and muscle make protein after hip surgery and before discharge from the hospital. Further, we will test the effects of a nutritional supplement and a common drug on these processes. Experimental Design (summary): This study will have 5 groups of randomly assigned patients. Group 1 will serve as a normal control group and be studied only once before surgery. Groups 2-5 will be studied immediately after hip arthroplasty (during surgical recovery) and again prior to discharge from the hospital after surgical intervention. These groups include placebo (Group 2), amino acid (AA) supplementation (Group 3), ketoconazole administration (Group 4), and a combined group to receive both ketoconazole and AA (Group 5). Significance (summary): Reducing the loss of muscle after surgery will help with recovery and return to normal function.

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