MECHANISMS OF MUSCLE PROTEIN LOSS AFTER HIP SURGERY/HIP FRACTURE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 背景：髋关节手术后的肌肉损失需要较长的康复期，并延迟恢复工作。 假设：减少身体的压力和增加其制造蛋白质的能力将减少髋关节手术后的肌肉损失，并有助于康复。 具体目的和程序（摘要）：我们将研究髋关节手术后和出院前身体和肌肉如何制造蛋白质。此外，我们将测试营养补充剂和常见药物对这些过程的影响。 实验设计（总结）：本研究将随机分配5组患者。第1组将作为正常对照组，仅在手术前研究一次。第2-5组将在髋关节置换术后立即（手术恢复期间）和手术干预后出院前再次进行研究。这些组包括安慰剂（第2组）、氨基酸（AA）补充剂（第3组）、酮康唑给药（第4组）和接受酮康唑和AA的联合组（第5组）。 意义（总结）：减少手术后肌肉的损失将有助于恢复和恢复正常功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Muscle loss after hip surgery requires a longer period of rehabilitation and delays the return to work. Hypothesis: Reducing the body's stress and increasing its ability to make protein will decrease muscle loss after hip surgery and help rehabilitation. Specific Aims and Procedures (summary): We will study how the body and muscle make protein after hip surgery and before discharge from the hospital. Further, we will test the effects of a nutritional supplement and a common drug on these processes. Experimental Design (summary): This study will have 5 groups of randomly assigned patients. Group 1 will serve as a normal control group and be studied only once before surgery. Groups 2-5 will be studied immediately after hip arthroplasty (during surgical recovery) and again prior to discharge from the hospital after surgical intervention. These groups include placebo (Group 2), amino acid (AA) supplementation (Group 3), ketoconazole administration (Group 4), and a combined group to receive both ketoconazole and AA (Group 5). Significance (summary): Reducing the loss of muscle after surgery will help with recovery and return to normal function.