Investigating the role of autophagic cell death during plant infection by the rice blast fungus Magnaporthe grisea

研究稻瘟病菌 Magnaporthe grisea 植物感染期间自噬细胞死亡的作用

• 批准号: BB/E022677/1
• 负责人: Nicholas Talbot
• 金额: $ 53.09万
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FE022677%2F1
• 关键词: Investigating; role; autophagic; cell; death

The aim of this project is to understand how rice plants become infected with a very serious disease called rice blast. Rice blast disease destroys up to 30% of the rice harvest each year and is a serious and recurrent threat to food security. We have discovered that the fungus that causes rice blast disease undergoes a form of programmed cell death that is necessary for it to bring about infection of a rice leaf. This project is designed to help us understand why a fungus undergoes this type of programmed suicide of its spores, in order to allow its specialised infection structures to function correctly. The project is significant because new control strategies are urgently required for rice blast disease. Fungicides are expensive and resistance to them can develop very rapidly. More durable control methods, either based on chemical intervention or resistance breeding, require a knowledge of the biology of the fungal agent responsible for this devastating disease. A large international community is studying rice blast because of its economic and social importance. Because of this, the genome of the fungus has been sequenced and many tools have been developed to study the fungus genetically. This provides a significant opportunity to learn more about fundamental biology of plant disease, but in a disease of international significance. The rice blast fungus is also similar to many of the fungi that cause disease on crops grown widely in the UK such as wheat and barley and its infection strategy is very similar to that of powdery mildews and rusts, for example. Knowledge gained from this project may therefore also benefit UK agriculture.

这个项目的目的是了解水稻如何感染一种叫做稻瘟病的非常严重的疾病。稻瘟病每年摧毁高达30%的水稻收成，是对粮食安全的严重和经常性威胁。我们已经发现，引起稻瘟病的真菌经历了一种程序性细胞死亡的形式，这是它感染水稻叶片所必需的。这个项目旨在帮助我们理解为什么真菌会经历这种孢子的程序性自杀，以便使其专门的感染结构正确发挥作用。该项目意义重大，因为迫切需要新的稻瘟病防治策略。杀真菌剂价格昂贵，对它们的抗药性会迅速产生。更持久的控制方法，无论是基于化学干预或抗性育种，都需要对这种毁灭性疾病的真菌因子的生物学知识。由于稻瘟病在经济和社会上的重要性，国际社会正在研究稻瘟病。正因为如此，真菌的基因组已被测序，并开发了许多工具来研究真菌的遗传。这提供了一个重要的机会，了解更多关于植物疾病的基础生物学，但在一个具有国际意义的疾病。稻瘟病真菌也类似于许多在英国广泛种植的作物（如小麦和大麦）上引起疾病的真菌，其感染策略与白粉病和锈病非常相似。因此，从该项目中获得的知识也可能使英国农业受益。

项目成果

Comparative genome analysis reveals an absence of leucine-rich repeat pattern-recognition receptor proteins in the kingdom Fungi.

• DOI: 10.1371/journal.pone.0012725
• 发表时间: 2010-09-14
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Soanes DM;Talbot NJ
• 通讯作者: Talbot NJ

Infection-associated nuclear degeneration in the rice blast fungus Magnaporthe oryzae requires non-selective macro-autophagy.

• DOI: 10.1371/journal.pone.0033270
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: He M;Kershaw MJ;Soanes DM;Xia Y;Talbot NJ
• 通讯作者: Talbot NJ