LSU DENTAL COBRE: DEVELOPMENT OF NEW ADHESIVE FLOURIDE-RELEASING MONOMERS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Recurrent caries is the most frequent cause for the failure of dental restorations. Fluoride-releasing restorative materials can reduce recurrent caries at the restoration margins. However, current dental composites and compomers have low fluoride release and recharge capabilities and they require bonding agents to bond to the tooth structure. Current dental bonding agents also have little fluoride-releasing and recharging capabilities and form a barrier hindering the transport of fluoride. Sealants have been used to fill the pits and fissures in posterior teeth but current sealants either release little fluoride or have poor adhesion. The goal of this project is to develop new fluoride-releasing dental bonding adhesives and sealants. We hypothesize that new fluoride-releasing dental bonding adhesives and sealants will release fluoride directly into the tooth structure, improve bonding, and facilitate the transport of fluoride from fluoride-releasing compomers and composites or topic fluoride agents to the tooth structure due to the fluorideexchange capability. Therefore, they can significantly reduce the recurrent caries and prolong the life of the restoration. The following is the progress in year 4. Objective: To synthesize new adhesive chelating monomers, F-exchange monomers and antibacterial monomers. To formulate and characterize novel antibacterial fluoride-releasing dental materials. To be trained to become independent researcher and to obtain a R01 grant. Methods: Worked with the mentoring team, attended the COBRE training program, conducted experiment with research associates Results: Three new adhesive chelating monomers containing 2,3-HOPO and their ternary zirconium fluoride chelates (F-releasing monomers) have been successfully synthesized. These F-releasing monomers are stable up to pH 7.5. Two new antibacterial monomers (AMs) and one reported antibacterial monomer (as control) have been synthesized. One of the new AMs has shown higher bactericidal effect against S. Mutans and better biocompatibility than the control AM. A new experimental antibacterial fluoride-releasing composite has been formulated and shown higher fluoride releasing and recharging capability than the control composite while it maintains similar physical and mechanical properties to the control composite. Discussion: An R01 application has been submitted but did not receive score. The new preliminary results are being included to the revised R01 application, which will be submitted before July 5th.