LSU DENTAL COBRE: DEVELOPMENT OF NEW ADHESIVE FLOURIDE-RELEASING MONOMERS

LSU Dental COBRE：新型粘合剂氟化物释放单体的开发

• 批准号: 7720559
• 负责人: XIAOMING XU
• 金额: $ 29.85万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720559
• 关键词: Adhesions; Adhesives; Anti-Bacterial Agents; Centers of Research Excellence; Compomers; Computer Retrieval of Information on Scientific Projects Database; Dental; Dental Bonding; Dental Materials; Dental Restoration Failure; Dental caries; Development; Fluorides; Funding; Goals; Grant; Institution; Life; Mechanics; Mentors; Methods; Object Attachment; Postdoctoral Fellow; Property; Recurrence; Reporting; Research; Research Personnel; Resources; Score; Source; Streptococcus mutans; Tooth structure; Training; Training Programs; United States National Institutes of Health; Work; Zirconium; bactericide; biomaterial compatibility; improved; monomer; novel; research study; restoration; restorative material; zirconium oxide

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Recurrent caries is the most frequent cause for the failure of dental restorations. Fluoride-releasing restorative materials can reduce recurrent caries at the restoration margins. However, current dental composites and compomers have low fluoride release and recharge capabilities and they require bonding agents to bond to the tooth structure. Current dental bonding agents also have little fluoride-releasing and recharging capabilities and form a barrier hindering the transport of fluoride. Sealants have been used to fill the pits and fissures in posterior teeth but current sealants either release little fluoride or have poor adhesion. The goal of this project is to develop new fluoride-releasing dental bonding adhesives and sealants. We hypothesize that new fluoride-releasing dental bonding adhesives and sealants will release fluoride directly into the tooth structure, improve bonding, and facilitate the transport of fluoride from fluoride-releasing compomers and composites or topic fluoride agents to the tooth structure due to the fluorideexchange capability. Therefore, they can significantly reduce the recurrent caries and prolong the life of the restoration. The following is the progress in year 4. Objective: To synthesize new adhesive chelating monomers, F-exchange monomers and antibacterial monomers. To formulate and characterize novel antibacterial fluoride-releasing dental materials. To be trained to become independent researcher and to obtain a R01 grant. Methods: Worked with the mentoring team, attended the COBRE training program, conducted experiment with research associates Results: Three new adhesive chelating monomers containing 2,3-HOPO and their ternary zirconium fluoride chelates (F-releasing monomers) have been successfully synthesized. These F-releasing monomers are stable up to pH 7.5. Two new antibacterial monomers (AMs) and one reported antibacterial monomer (as control) have been synthesized. One of the new AMs has shown higher bactericidal effect against S. Mutans and better biocompatibility than the control AM. A new experimental antibacterial fluoride-releasing composite has been formulated and shown higher fluoride releasing and recharging capability than the control composite while it maintains similar physical and mechanical properties to the control composite. Discussion: An R01 application has been submitted but did not receive score. The new preliminary results are being included to the revised R01 application, which will be submitted before July 5th.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 简介：经常性龋齿是导致牙齿修复体失败的最常见原因。释放氟化物的恢复材料可以减少恢复边缘的复发性龋齿。但是，当前的牙科复合材料和兼容物具有较低的氟化物释放和充电能力，它们需要粘结剂才能粘合到牙齿结构。当前的牙齿粘合剂也很少释放氟化物和充电功能，并形成阻碍氟化物运输的屏障。密封剂已被用来填充凹坑和后牙的裂缝，但目前的密封剂要么释放氟化物，要么粘附不良。该项目的目的是开发新的氟化物释放牙齿粘合剂和密封剂。我们假设新的释放氟化物的牙齿粘合剂和密封剂将氟化物直接释放到牙齿结构中，改善粘合物，并促进氟化物从氟化物释放的复合材料和复合材料或氟化物材料从氟化物交换能力引起的牙齿结构。因此，它们可以显着减少复发性的龋齿并延长恢复的寿命。以下是第4年的进展。 目的：合成新的粘合性螯合单体，F-交换单体和抗菌单体。制定和表征新型抗菌氟化物释放牙科材料。接受培训，成为独立研究人员并获得R01赠款。 方法：与指导团队合作，参加了鞋垫培训计划，与研究协会进行了实验 结果：已经成功合成了三个含有2,3-HOPO及其三元锆螯合物（F-释放单体）的新的粘合性螯合单体。这些释放F的单体稳定至pH 7.5。已经合成了两个新的抗菌单体（AMS）和一个报道的抗菌单体（作为对照）。与对照AM相比，新的AM之一显示出对链球菌的杀菌作用更高，生物相容性更好。与控制复合材料相比，已经制定了一种新的实验性抗菌氟化物释放复合材料并显示出更高的氟化物释放和充电能力，而它具有与控制复合材料相似的物理和机械性能。 讨论：已提交R01申请，但未获得分数。新的初步结果将包括在修订后的R01申请中，该申请将在7月5日之前提交。