LSU DENTAL COBRE: DEVELOPMENT OF NEW ADHESIVE FLOURIDE-RELEASING MONOMERS

LSU Dental COBRE：新型粘合剂氟化物释放单体的开发

• 批准号: 7720559
• 负责人: XIAOMING XU
• 金额: $ 29.85万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720559
• 关键词: Adhesions; Adhesives; Anti-Bacterial Agents; Centers of Research Excellence; Compomers; Computer Retrieval of Information on Scientific Projects Database; Dental; Dental Bonding; Dental Materials; Dental Restoration Failure; Dental caries; Development; Fluorides; Funding; Goals; Grant; Institution; Life; Mechanics; Mentors; Methods; Object Attachment; Postdoctoral Fellow; Property; Recurrence; Reporting; Research; Research Personnel; Resources; Score; Source; Streptococcus mutans; Tooth structure; Training; Training Programs; United States National Institutes of Health; Work; Zirconium; bactericide; biomaterial compatibility; improved; monomer; novel; research study; restoration; restorative material; zirconium oxide

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Recurrent caries is the most frequent cause for the failure of dental restorations. Fluoride-releasing restorative materials can reduce recurrent caries at the restoration margins. However, current dental composites and compomers have low fluoride release and recharge capabilities and they require bonding agents to bond to the tooth structure. Current dental bonding agents also have little fluoride-releasing and recharging capabilities and form a barrier hindering the transport of fluoride. Sealants have been used to fill the pits and fissures in posterior teeth but current sealants either release little fluoride or have poor adhesion. The goal of this project is to develop new fluoride-releasing dental bonding adhesives and sealants. We hypothesize that new fluoride-releasing dental bonding adhesives and sealants will release fluoride directly into the tooth structure, improve bonding, and facilitate the transport of fluoride from fluoride-releasing compomers and composites or topic fluoride agents to the tooth structure due to the fluorideexchange capability. Therefore, they can significantly reduce the recurrent caries and prolong the life of the restoration. The following is the progress in year 4. Objective: To synthesize new adhesive chelating monomers, F-exchange monomers and antibacterial monomers. To formulate and characterize novel antibacterial fluoride-releasing dental materials. To be trained to become independent researcher and to obtain a R01 grant. Methods: Worked with the mentoring team, attended the COBRE training program, conducted experiment with research associates Results: Three new adhesive chelating monomers containing 2,3-HOPO and their ternary zirconium fluoride chelates (F-releasing monomers) have been successfully synthesized. These F-releasing monomers are stable up to pH 7.5. Two new antibacterial monomers (AMs) and one reported antibacterial monomer (as control) have been synthesized. One of the new AMs has shown higher bactericidal effect against S. Mutans and better biocompatibility than the control AM. A new experimental antibacterial fluoride-releasing composite has been formulated and shown higher fluoride releasing and recharging capability than the control composite while it maintains similar physical and mechanical properties to the control composite. Discussion: An R01 application has been submitted but did not receive score. The new preliminary results are being included to the revised R01 application, which will be submitted before July 5th.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 前言：复发的龋病是导致牙体修复失败的最常见原因。释放氟化物的修复材料可以减少修复边缘的复发龋齿。然而，目前的牙科复合材料和复合体具有较低的氟化物释放和充电能力，它们需要粘结剂才能结合到牙齿结构上。目前的牙科粘结剂也几乎没有氟化物的释放和再充电能力，并且形成了阻碍氟化物运输的屏障。封闭剂已经被用来填充后牙的凹陷和裂隙，但目前的封闭剂要么释放很少的氟化物，要么粘附性差。该项目的目标是开发新型氟化物释放型牙科粘接剂和密封剂。我们推测，由于氟离子交换能力，新型释氟牙科粘结剂和封闭剂将直接将氟化物释放到牙齿结构中，改善粘接性能，并促进氟化物从释氟化合物和复合材料或主题氟化物向牙齿结构的传输。因此，它们可以显著减少龋病复发，延长修复体的寿命。以下是第四年的进展情况。 目的：合成新型胶粘剂螯合单体、氟交换单体和抗菌单体。研制和表征新型抗菌释氟牙科材料。接受培训成为独立研究人员，并获得R01拨款。 方法：与指导团队合作，参加Cobre培训计划，与研究人员一起进行实验 结果：成功合成了3种含2，3-HOPO及其三元氟化锆络合物(释氟单体)的新型黏附性螯合单体。这些释放氟的单体在pH 7.5以下都是稳定的。合成了两个新的抗菌单体(AM)和一个已报道的抗菌单体(对照)。其中一种新的AM对变形链球菌显示出更高的杀菌效果，并且比对照AM具有更好的生物相容性研制了一种新型抗菌释氟复合材料，在保持与对照复合材料相似的物理力学性能的同时，表现出比对照复合材料更高的释氟和充电能力。 讨论：已提交R01申请，但未收到分数。新的初步结果将包括在修订后的R01申请中，该申请将于7月5日之前提交。