LSU DENTAL COBRE: DEVELOPMENT OF NEW ADHESIVE FLOURIDE-RELEASING MONOMERS

LSU Dental COBRE：新型粘合剂氟化物释放单体的开发

• 批准号: 7720559
• 负责人: XIAOMING XU
• 金额: $ 29.85万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720559
• 关键词: Adhesions; Adhesives; Anti-Bacterial Agents; Centers of Research Excellence; Compomers; Computer Retrieval of Information on Scientific Projects Database; Dental; Dental Bonding; Dental Materials; Dental Restoration Failure; Dental caries; Development; Fluorides; Funding; Goals; Grant; Institution; Life; Mechanics; Mentors; Methods; Object Attachment; Postdoctoral Fellow; Property; Recurrence; Reporting; Research; Research Personnel; Resources; Score; Source; Streptococcus mutans; Tooth structure; Training; Training Programs; United States National Institutes of Health; Work; Zirconium; bactericide; biomaterial compatibility; improved; monomer; novel; research study; restoration; restorative material; zirconium oxide

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Recurrent caries is the most frequent cause for the failure of dental restorations. Fluoride-releasing restorative materials can reduce recurrent caries at the restoration margins. However, current dental composites and compomers have low fluoride release and recharge capabilities and they require bonding agents to bond to the tooth structure. Current dental bonding agents also have little fluoride-releasing and recharging capabilities and form a barrier hindering the transport of fluoride. Sealants have been used to fill the pits and fissures in posterior teeth but current sealants either release little fluoride or have poor adhesion. The goal of this project is to develop new fluoride-releasing dental bonding adhesives and sealants. We hypothesize that new fluoride-releasing dental bonding adhesives and sealants will release fluoride directly into the tooth structure, improve bonding, and facilitate the transport of fluoride from fluoride-releasing compomers and composites or topic fluoride agents to the tooth structure due to the fluorideexchange capability. Therefore, they can significantly reduce the recurrent caries and prolong the life of the restoration. The following is the progress in year 4. Objective: To synthesize new adhesive chelating monomers, F-exchange monomers and antibacterial monomers. To formulate and characterize novel antibacterial fluoride-releasing dental materials. To be trained to become independent researcher and to obtain a R01 grant. Methods: Worked with the mentoring team, attended the COBRE training program, conducted experiment with research associates Results: Three new adhesive chelating monomers containing 2,3-HOPO and their ternary zirconium fluoride chelates (F-releasing monomers) have been successfully synthesized. These F-releasing monomers are stable up to pH 7.5. Two new antibacterial monomers (AMs) and one reported antibacterial monomer (as control) have been synthesized. One of the new AMs has shown higher bactericidal effect against S. Mutans and better biocompatibility than the control AM. A new experimental antibacterial fluoride-releasing composite has been formulated and shown higher fluoride releasing and recharging capability than the control composite while it maintains similar physical and mechanical properties to the control composite. Discussion: An R01 application has been submitted but did not receive score. The new preliminary results are being included to the revised R01 application, which will be submitted before July 5th.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 简介：复发性龋齿是牙科治疗失败的最常见原因。释放氟化物的修复材料可以减少修复边缘的复发性龋。然而，目前的牙科复合材料和复合体具有低的氟化物释放和再充电能力，并且它们需要粘合剂来粘合到牙齿结构。目前的牙科粘合剂也几乎没有氟化物释放和再充电能力，并形成阻碍氟化物运输的屏障。密封剂已被用于填充后牙的窝沟和裂缝，但目前的密封剂要么释放很少的氟化物，要么粘附力差。本项目的目标是开发新的氟化物释放牙科粘合剂和密封剂。我们假设，新的释放氟化物的牙科粘接剂和密封剂将释放氟化物直接进入牙齿结构，改善粘接，并促进氟化物从释放氟化物的复合物和复合物或局部氟化物剂运输到牙齿结构，交换能力。因此，它们可以显着减少复发性龋齿并延长修复体的寿命。以下是第四年的进展。 目的：合成新型粘附性螯合单体、氟交换单体和抗菌单体。制备新型抗菌释氟牙科材料并进行表征。接受培训，成为独立的研究人员，并获得R 01赠款。 方法：与导师团队合作，参加COBRE培训计划，与研究助理一起进行实验 结果如下：合成了三种含2，3-HOPO的新型粘合性螯合单体及其三元氟化锆螯合物（释氟单体）。这些释放F的单体在pH 7.5以下是稳定的。合成了两种新的抗菌单体和一种已报道的抗菌单体（作为对照）。其中一种新的AM对沙门氏菌有较好的杀菌效果。与对照AM相比，突变体和更好的生物相容性。一种新的实验性抗菌氟化物释放复合材料已被配制并显示出比对照复合材料更高的氟化物释放和再充电能力，同时它保持与对照复合材料相似的物理和机械性能。 讨论：R 01申请已提交，但未收到分数。新的初步结果将包含在修订后的R 01申请中，该申请将于7月5日之前提交。