LSU DENTAL COBRE: DEVELOPMENT OF NEW ADHESIVE FLOURIDE-RELEASING MONOMERS

LSU Dental COBRE：新型粘合剂氟化物释放单体的开发

• 批准号: 7720559
• 负责人: XIAOMING XU
• 金额: $ 29.85万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720559
• 关键词: Adhesions; Adhesives; Anti-Bacterial Agents; Centers of Research Excellence; Compomers; Computer Retrieval of Information on Scientific Projects Database; Dental; Dental Bonding; Dental Materials; Dental Restoration Failure; Dental caries; Development; Fluorides; Funding; Goals; Grant; Institution; Life; Mechanics; Mentors; Methods; Object Attachment; Postdoctoral Fellow; Property; Recurrence; Reporting; Research; Research Personnel; Resources; Score; Source; Streptococcus mutans; Tooth structure; Training; Training Programs; United States National Institutes of Health; Work; Zirconium; bactericide; biomaterial compatibility; improved; monomer; novel; research study; restoration; restorative material; zirconium oxide

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Recurrent caries is the most frequent cause for the failure of dental restorations. Fluoride-releasing restorative materials can reduce recurrent caries at the restoration margins. However, current dental composites and compomers have low fluoride release and recharge capabilities and they require bonding agents to bond to the tooth structure. Current dental bonding agents also have little fluoride-releasing and recharging capabilities and form a barrier hindering the transport of fluoride. Sealants have been used to fill the pits and fissures in posterior teeth but current sealants either release little fluoride or have poor adhesion. The goal of this project is to develop new fluoride-releasing dental bonding adhesives and sealants. We hypothesize that new fluoride-releasing dental bonding adhesives and sealants will release fluoride directly into the tooth structure, improve bonding, and facilitate the transport of fluoride from fluoride-releasing compomers and composites or topic fluoride agents to the tooth structure due to the fluorideexchange capability. Therefore, they can significantly reduce the recurrent caries and prolong the life of the restoration. The following is the progress in year 4. Objective: To synthesize new adhesive chelating monomers, F-exchange monomers and antibacterial monomers. To formulate and characterize novel antibacterial fluoride-releasing dental materials. To be trained to become independent researcher and to obtain a R01 grant. Methods: Worked with the mentoring team, attended the COBRE training program, conducted experiment with research associates Results: Three new adhesive chelating monomers containing 2,3-HOPO and their ternary zirconium fluoride chelates (F-releasing monomers) have been successfully synthesized. These F-releasing monomers are stable up to pH 7.5. Two new antibacterial monomers (AMs) and one reported antibacterial monomer (as control) have been synthesized. One of the new AMs has shown higher bactericidal effect against S. Mutans and better biocompatibility than the control AM. A new experimental antibacterial fluoride-releasing composite has been formulated and shown higher fluoride releasing and recharging capability than the control composite while it maintains similar physical and mechanical properties to the control composite. Discussion: An R01 application has been submitted but did not receive score. The new preliminary results are being included to the revised R01 application, which will be submitted before July 5th.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 简介： 复发性龋齿是牙齿修复失败的最常见原因。释放氟化物的修复材料可以减少修复体边缘的复发性龋齿。然而，当前的牙科复合材料和复合体的氟化物释放和补给能力较低，并且它们需要粘合剂来粘合到牙齿结构。目前的牙科粘合剂也几乎没有氟化物释放和再充电能力，并形成阻碍氟化物传输的屏障。密封剂已被用来填充后牙的凹坑和裂隙，但目前的密封剂要么释放很少的氟化物，要么粘附力差。该项目的目标是开发新型的释放氟化物的牙科粘合胶和密封剂。我们假设新型释放氟化物的牙科粘合粘合剂和密封剂将直接将氟化物释放到牙齿结构中，改善粘合，并由于氟化物交换能力而促进氟化物从释放氟化物的复合体和复合材料或局部氟化剂传输到牙齿结构。因此，它们可以显着减少复发龋齿并延长修复体的寿命。以下是第4年的进展。 目的：合成新型粘合剂螯合单体、氟交换单体和抗菌单体。配制并表征新型抗菌释放氟化物牙科材料。接受培训成为独立研究员并获得 R01 资助。 方法：与导师团队合作，参加 COBRE 培训计划，与研究员一起进行实验 结果：成功合成了三种含有2,3-HOPO及其三元氟化锆螯合物（释氟单体）的新型粘合剂螯合单体。这些释放 F 的单体在 pH 值达 7.5 时仍保持稳定。合成了两种新的抗菌单体（AM）和一种报道的抗菌单体（作为对照）。与对照 AM 相比，其中一种新型 AM 对变形链球菌具有更高的杀菌效果，并且具有更好的生物相容性。配制了一种新的实验性抗菌释氟复合材料，与对照复合材料相比，它表现出更高的氟化物释放和再充电能力，同时保持与对照复合材料相似的物理和机械性能。 讨论：R01申请已提交但未收到分数。新的初步结果将包含在修订后的 R01 申请中，该申请将于 7 月 5 日之前提交。