LSU DENTAL COBRE: DEVELOPMENT OF NEW ADHESIVE FLOURIDE-RELEASING MONOMERS

LSU Dental COBRE：新型粘合剂氟化物释放单体的开发

• 批准号: 7610699
• 负责人: XIAOMING XU
• 金额: $ 26.4万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610699
• 关键词: Acidity; Adhesions; Adhesives; Centers of Research Excellence; Compomers; Computer Retrieval of Information on Scientific Projects Database; Dental; Dental Bonding; Dental Restoration Failure; Dental caries; Development; Fluorides; Foundations; Funding; Future; Goals; Grant; Institution; Laboratories; Life; Mentors; Metals; Methods; Object Attachment; Organic solvent product; Postdoctoral Fellow; Recurrence; Research; Research Personnel; Resources; Source; Tooth structure; Training; Training Programs; United States National Institutes of Health; Water; Work; improved; monomer; restoration; restorative material

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Recurrent caries is the most frequent cause for the failure of dental restorations. Fluoride-releasing restorative materials can reduce recurrent caries at the restoration margins. However, current dental composites and compomers have low fluoride release and recharge capabilities and they require bonding agents to bond to the tooth structure. Current dental bonding agents also have little fluoride-releasing and recharging capabilities and form a barrier hindering the transport of fluoride. Sealants have been used to fill the pits and fissures in posterior teeth but current sealants either release little fluoride or have poor adhesion. The goal of this project is to develop new fluoride-releasing dental bonding adhesives and sealants. We hypothesize that new fluoride-releasing dental bonding adhesives and sealants will release fluoride directly into the tooth structure, improve bonding, and facilitate the transport of fluoride from fluoride-releasing compomers and composites or topic fluoride agents to the tooth structure due to the fluoride?exchange capability. Therefore, they can significantly reduce the recurrent caries and prolong the life of the restoration. The following is the progress in year1. Objective: To synthesize new adhesive chelating monomers and F-exchange chelates. To be trained to become independent researcher and to obtain a R01 grant. Methods: Worked with the mentoring team, attended the COBRE training program, set up a new laboratory, hired and trained research associates. Results: Four new adhesive chelating monomers have been successfully synthesized. These monomers can form stable ternary metal fluoride (F-exchange) chelates that are soluble in mixed water?organic solvents. Three of the monomers may be used in self-etching primer (bonding agents) due to their high acidity, and one of them may be used in adhesives and sealants due to its high fluoride-exchange capability. Discussion: These preliminary results have laid an important foundation for the next year?s study and the future R01 application.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 简介：复发性龋齿是牙科治疗失败的最常见原因。释放氟化物的修复材料可以减少修复边缘的复发性龋。然而，目前的牙科复合材料和复合体具有低的氟化物释放和再充电能力，并且它们需要粘合剂来粘合到牙齿结构。目前的牙科粘合剂也几乎没有氟化物释放和再充电能力，并形成阻碍氟化物运输的屏障。密封剂已被用于填充后牙的窝沟和裂缝，但目前的密封剂要么释放很少的氟化物，要么粘附力差。本项目的目标是开发新的氟化物释放牙科粘合剂和密封剂。我们假设，新的氟化物释放牙科粘合剂和密封剂将释放氟化物直接进入牙齿结构，改善粘接，并促进氟化物从氟化物释放复合物和复合材料或局部氟化物剂的牙齿结构，由于氟化物？交换能力。因此，它们可以显着减少复发性龋齿并延长修复体的寿命。以下是第一年的进展。 目的：合成新型粘附性螯合单体及氟交换螯合物。接受培训，成为独立的研究人员，并获得R 01赠款。 方法：与导师团队合作，参加COBRE培训计划，建立新的实验室，聘请和培训研究助理。 结果：成功合成了4种新型粘合剂螯合单体。这些单体可以形成稳定的三元金属氟化物（F-交换）螯合物，可溶于混合水？有机溶剂其中三种单体由于其高酸性可用于自蚀刻底漆（粘合剂），其中一种单体由于其高氟化物交换能力可用于粘合剂和密封剂。 讨论：这些初步成果是否为明年打下了重要基础？的研究和R 01的应用前景。