UKY DENTAL COBRE: BIOINFORMATICS & BIOSTATISTICS CORE

英国牙科 COBRE：生物信息学

• 批准号: 7382113
• 负责人: Richard J. Kryscio
• 金额: $ 22.5万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382113
• 关键词: UKY; DENTAL; COBRE; BIOINFORMATICS; BIOSTATISTICS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This core provides expert advice on experimental design, data management, subject recruitment, and data analysis to the clinical projects in this COBRE and it provides expertise on the analysis of the bioinformatics data generated in the basic science projects. This advice promotes efficiency in terms of the minimal number of patients to be recruited to a clinical study or the minimum number of chips to be processed in a microarray experiment so that information is maximized. Advice rendered at an early stage in the design of the project makes a difference. It also significantly improves the chances that the project will be successful as evidenced by the role this core played in one success in each area. Inherent in this core is a training component since its personnel supervise graduate students trainees in their own discipline and work on a one to one basis with young investigators in the dental sciences. The younger faculty in this core are also mentored by the senior faculty. A journal paper summarizing a pilot project supporting a current clinical project and several abstracts based on related dental graduate student research have been submitted. An R01 application in the basic science area, in which this core provided key technical support, has been awarded and another application is in progress. As the projects in this COBRE mature personnel in this core will analyze the data generated and when needed will create new methodology to help interpret the results.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该核心为COBRE中的临床项目提供实验设计，数据管理，受试者招募和数据分析方面的专家建议，并提供基础科学项目中生成的生物信息学数据分析方面的专业知识。这一建议提高了临床研究中招募的患者数量最少或微阵列实验中处理的芯片数量最少的效率，从而使信息最大化。在项目设计的早期阶段提供咨询意见会产生影响。它还大大提高了项目成功的机会，这一点可以从该核心在每个领域的成功中所发挥的作用中得到证明。这一核心的内在组成部分是培训，因为其工作人员监督研究生学员在自己的学科，并在一对一的基础上与年轻的研究人员在牙科科学。这个核心的年轻教师也由高级教师指导。已提交了一篇期刊论文，总结了一个支持当前临床项目的试点项目和几篇基于相关牙科研究生研究的摘要。在基础科学领域的R 01应用中，该核心提供了关键的技术支持，已获得批准，另一项应用正在进行中。随着COBRE项目的成熟，核心人员将分析生成的数据，并在需要时创建新的方法来帮助解释结果。