UKY DENTAL COBRE: BIOINFORMATICS & BIOSTATISTICS CORE

英国牙科 COBRE：生物信息学

• 批准号: 7382113
• 负责人: Richard J. Kryscio
• 金额: $ 22.5万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382113
• 关键词: UKY; DENTAL; COBRE; BIOINFORMATICS; BIOSTATISTICS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This core provides expert advice on experimental design, data management, subject recruitment, and data analysis to the clinical projects in this COBRE and it provides expertise on the analysis of the bioinformatics data generated in the basic science projects. This advice promotes efficiency in terms of the minimal number of patients to be recruited to a clinical study or the minimum number of chips to be processed in a microarray experiment so that information is maximized. Advice rendered at an early stage in the design of the project makes a difference. It also significantly improves the chances that the project will be successful as evidenced by the role this core played in one success in each area. Inherent in this core is a training component since its personnel supervise graduate students trainees in their own discipline and work on a one to one basis with young investigators in the dental sciences. The younger faculty in this core are also mentored by the senior faculty. A journal paper summarizing a pilot project supporting a current clinical project and several abstracts based on related dental graduate student research have been submitted. An R01 application in the basic science area, in which this core provided key technical support, has been awarded and another application is in progress. As the projects in this COBRE mature personnel in this core will analyze the data generated and when needed will create new methodology to help interpret the results.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该核心向该圆锥形的临床项目提供了有关实验设计，数据管理，主题招聘和数据分析的专家建议，并为基础科学项目中生成的生物信息学数据分析提供了专业知识。该建议从招募到临床研究的患者数量或在微阵列实验中处理的最少芯片数量来促进效率，从而最大程度地提高信息。在项目设计的早期阶段提供的建议会有所作为。这也显着提高了该项目将成功的机会，这是由于该核心在每个领域的一个成功中所扮演的角色所证明的。该核心固有的是培训组成部分，因为其人员监督了自己的学科研究生学员，并与牙科科学的年轻调查员一对一地工作。该核心的年轻教师也受到高级教师的指导。一份汇总了一个支持当前临床项目的试点项目的杂志论文，并提交了基于相关牙科研究生研究的一些摘要。基础科学领域的R01应用程序已授予该核心提供的重要技术支持，并正在进行另一个应用程序。随着该核心成熟人员中的项目将分析生成的数据，并在需要时创建新方法来帮助解释结果。