Core C: University of Kentucky Alzheimer's Disease Core Center

核心C：肯塔基大学阿尔茨海默病核心中心

• 批准号: 10689361
• 负责人: Richard J. Kryscio
• 金额: $ 22.93万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689361
• 关键词: Advisory Committees; Aging; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Applications Grants; Attention; Bioinformatics; Biological Markers; Biometry; COVID-19 pandemic; Clinical; Clinical Data; Clinical Trials; Clinical Trials Data Monitoring Committees; Cognitive; Collaborations; Communities; Computer software; Consult; Data; Data Analyses; Data Collection; Dementia; Development; Elderly; Elements; Enrollment; Environment; Epidemiology; Etiology; Evaluation; Event; Experimental Designs; Extramural Activities; Faculty; Funding; Generations; Genetic; Gerontology; Information Systems; Interruption; Kentucky; Leadership; Life; Literature; Manuscripts; Methodology; Mission; Neuroepidemiology; Observational Study; Online Systems; Participant; Pathology; Pilot Projects; Procedures; Psychology; Public Health; Publications; Reporting; Research; Research Design; Research Methodology; Research Personnel; Resources; Risk Factors; Role; Sampling; Seasons; Services; Software Engineering; Statistical Data Interpretation; Study Section; System; Tablets; Time; Training; Universities; Ursidae Family; Vision; base; central database; clinical biomarkers; cohort; dashboard; data dictionary; data management; data warehouse; direct application; doctoral student; education research; electronic data capture system; improved; innovation; interest; meetings; member; mixed dementia; neuropathology; novel; outreach; portability; programs; recruit; statistics; student training; success; user-friendly; web app; web site

Project Summary/Abstract: Data Management and Statistics Core The Data Management and Statistics (DMS) Core can be conceptualized as the lynchpin for integration of the ADRC Cores and is vital to the success of the UK-ADRC. Its critical roles include managing a large centralized database, consulting with ADRC-affiliated researchers, and working to develop and apply innovative statistical methodology for data analysis. Data management efforts focus on collecting, storing, and sharing high quality data using a web-based platform. This focus begins with the leadership and vision and attention to detail provided by the DMS Core. This core has an enviable track record of timely and accurate reporting of a high volume of data to NACC. Further, weekly Core meetings are popular with UK-ADRC investigators who find that the expert advice provided by our seasoned investigators improves their success in pilot studies, grant applications, and publications. The Core also participates as a full partner to the research mission of the UK- ADRC emphasizing transitions in late life from normal to multiple etiology dementia. A key element of this Core is the well-established track record of developing novel methodology to analyze data collected at the UK- ADRC and from other cohorts with a focus on elderly subjects’ transitions to MCI and eventually dementia. The Core also provides training for students enrolled in the graduate programs in Gerontology, Public Health, Epidemiology and Biostatistics, Psychology, and Statistics. It is committed to developing younger faculty to become productive ADRC investigators. In keeping with the mission of the UK-ADRC, faculty in this Core also contribute to the dementia research community at large through service on external advisory committees, study sections, manuscript reviews, and data safety monitoring boards. The DMS Core will continue these critical responsibilities through the following specific aims. Aim 1: Maintain and expand an integrated data warehouse and suite of web-based data collection applications and reporting platforms for ADRC Cores and projects. Aim 2: Provide expertise on experimental design and statistical analysis. Aim 3: Support the clinical, biomarker, neuropathological, educational, and outreach missions of the ADRC. Aim 4: Contribute to the activities of the dementia community at large through service and research.

项目摘要/摘要：数据管理与统计核心