Core C: University of Kentucky Alzheimer's Disease Core Center

核心C：肯塔基大学阿尔茨海默病核心中心

• 批准号: 10261964
• 负责人: Richard J. Kryscio
• 金额: $ 34.29万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10261964
• 关键词: Advisory Committees; Aging; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Applications Grants; Attention; Bioinformatics; Biological Markers; Biometry; COVID-19 pandemic; Clinical; Clinical Data; Clinical Trials; Clinical Trials Data Monitoring Committees; Cognitive; Collaborations; Communities; Consult; Data; Data Analyses; Data Collection; Dementia; Development; Elderly; Elements; Enrollment; Environment; Epidemiology; Etiology; Evaluation; Event; Experimental Designs; Extramural Activities; Faculty; Funding; Generations; Genetic; Gerontology; Health Services Research; Information Systems; Interruption; Kentucky; Leadership; Life; Literature; Manuscripts; Methodology; Mission; Neuroepidemiology; Observational Study; Online Systems; Participant; Pathology; Pilot Projects; Procedures; Psychology; Public Health; Publications; Reporting; Research; Research Design; Research Methodology; Research Personnel; Resources; Risk Factors; Role; Sampling; Seasons; Services; Statistical Data Interpretation; Study Section; System; Tablets; Time; Training; Universities; Ursidae Family; Vision; base; central database; clinical biomarkers; cohort; dashboard; data dictionary; data management; data warehouse; direct application; doctoral student; education research; electronic data capture system; improved; innovation; interest; meetings; member; mixed dementia; neuropathology; novel; outreach; programs; recruit; statistics; student training; success; user-friendly; web app; web site

Project Summary/Abstract: Data Management and Statistics Core The Data Management and Statistics (DMS) Core can be conceptualized as the lynchpin for integration of the ADRC Cores and is vital to the success of the UK-ADRC. Its critical roles include managing a large centralized database, consulting with ADRC-affiliated researchers, and working to develop and apply innovative statistical methodology for data analysis. Data management efforts focus on collecting, storing, and sharing high quality data using a web-based platform. This focus begins with the leadership and vision and attention to detail provided by the DMS Core. This core has an enviable track record of timely and accurate reporting of a high volume of data to NACC. Further, weekly Core meetings are popular with UK-ADRC investigators who find that the expert advice provided by our seasoned investigators improves their success in pilot studies, grant applications, and publications. The Core also participates as a full partner to the research mission of the UK- ADRC emphasizing transitions in late life from normal to multiple etiology dementia. A key element of this Core is the well-established track record of developing novel methodology to analyze data collected at the UK- ADRC and from other cohorts with a focus on elderly subjects’ transitions to MCI and eventually dementia. The Core also provides training for students enrolled in the graduate programs in Gerontology, Public Health, Epidemiology and Biostatistics, Psychology, and Statistics. It is committed to developing younger faculty to become productive ADRC investigators. In keeping with the mission of the UK-ADRC, faculty in this Core also contribute to the dementia research community at large through service on external advisory committees, study sections, manuscript reviews, and data safety monitoring boards. The DMS Core will continue these critical responsibilities through the following specific aims. Aim 1: Maintain and expand an integrated data warehouse and suite of web-based data collection applications and reporting platforms for ADRC Cores and projects. Aim 2: Provide expertise on experimental design and statistical analysis. Aim 3: Support the clinical, biomarker, neuropathological, educational, and outreach missions of the ADRC. Aim 4: Contribute to the activities of the dementia community at large through service and research.

项目摘要/摘要：数据管理和统计核心 数据管理和统计（DMS）核心可以被概念化为集成 ADRC核心，对英国-ADRC的成功至关重要。它的关键作用包括管理大型集中式 数据库，与ADRC附属研究人员进行咨询，并努力开发和应用创新统计数据 数据分析的方法。数据管理工作重点是收集，存储和共享高质量 使用基于Web的平台的数据。这个重点始于领导力，远见和对细节的关注 由DMS核心提供。该核心具有令人羡慕的及时和准确报告的记录 数据量到NACC。此外，每周的核心会议在英国-ADRC调查人员中很受欢迎，他们发现 我们经验丰富的调查人员提供的专家建议改善了他们在试点研究中的成功，格兰特 申请和出版物。核心还作为英国研究任务的正式合作伙伴 - ADRC强调了晚期从正常生活到多种病因痴呆的过渡。这个关键要素 核心是开发新方法的良好往绩，以分析在英国收集的数据 - ADRC和其他同类人群，重点是较早的受试者向MCI和最终痴呆症的过渡。这 Core还为参加老年研究生课程的学生提供培训，公共卫生， 流行病学和生物统计学，心理学和统计学。它致力于发展年轻教师 成为富有生产力的ADRC调查人员。为了符合英国-ADRC的使命，该核心的教师也 通过外部咨询委员会的服务为痴呆症研究社区做出贡献， 研究部分，手稿评论和数据安全监控板。 DMS核心将继续这些 通过以下特定目标承担关键责任。 目标1：维护和扩展基于Web的数据收集应用程序的集成数据仓库和套件 以及针对ADRC核心和项目的报告平台。 目标2：提供实验设计和统计分析的专业知识。 目标3：支持ADRC的临床，生物标志物，神经病理学，教育和外展任务。 目标4：通过服务和研究为痴呆症社区的活动做出贡献。