UKY DENTAL COBRE: BIOINFORMATICS & BIOSTATISTICS CORE

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该核心为 COBRE 中的临床项目提供实验设计、数据管理、受试者招募和数据分析方面的专家建议，并提供基础科学项目中生成的生物信息学数据分析的专业知识。 该建议提高了临床研究中招募的患者数量最少或微阵列实验中处理的芯片数量最少的效率，从而使信息最大化。在项目设计的早期阶段提供的建议会产生影响。它还显着提高了项目成功的机会，正如该核心在每个领域的成功中所发挥的作用所证明的那样。这一核心固有的是培训部分，因为其人员在自己的学科中监督研究生受训者，并与牙科科学领域的年轻研究人员进行一对一的工作。 该核心的年轻教师也受到资深教师的指导。 已经提交了一篇期刊论文，总结了支持当前临床项目的试点项目以及基于相关牙科研究生研究的几份摘要。该核心提供关键技术支持的基础科学领域R01申请已获得批准，另一项申请正在进行中。 由于 COBRE 中的项目，该核心的成熟人员将分析生成的数据，并在需要时创建新的方法来帮助解释结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This core provides expert advice on experimental design, data management, subject recruitment, and data analysis to the clinical projects in this COBRE and it provides expertise on the analysis of the bioinformatics data generated in the basic science projects. This advice promotes efficiency in terms of the minimal number of patients to be recruited to a clinical study or the minimum number of chips to be processed in a microarray experiment so that information is maximized. Advice rendered at an early stage in the design of the project makes a difference. It also significantly improves the chances that the project will be successful as evidenced by the role this core played in one success in each area. Inherent in this core is a training component since its personnel supervise graduate students trainees in their own discipline and work on a one to one basis with young investigators in the dental sciences. The younger faculty in this core are also mentored by the senior faculty. A journal paper summarizing a pilot project supporting a current clinical project and several abstracts based on related dental graduate student research have been submitted. An R01 application in the basic science area, in which this core provided key technical support, has been awarded and another application is in progress. As the projects in this COBRE mature personnel in this core will analyze the data generated and when needed will create new methodology to help interpret the results.