UKY DENTAL COBRE: BIOINFORMATICS & BIOSTATISTICS CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该核心为Cobre的临床项目提供实验设计、数据管理、受试者招募和数据分析方面的专家建议，并提供在分析基础科学项目中产生的生物信息学数据方面的专业知识。这一建议提高了效率，因为在临床研究中招募的患者数量最少，或者在微阵列实验中处理的芯片数量最少，从而使信息最大化。在项目设计的早期阶段提供的建议会有所不同。它还大大提高了项目成功的机会，这一核心在每个领域的一次成功中发挥的作用就是明证。这一核心中固有的是培训部分，因为它的工作人员在自己的学科中监督研究生、受训者，并与牙科领域的年轻研究人员一对一地工作。这一核心中的年轻教员也由资深教员指导。一篇期刊论文总结了一个支持当前临床项目的试点项目，并提交了几个基于相关牙科研究生研究的摘要。这一核心提供了关键技术支持的基础科学领域的一项R01申请已经获批，另一项申请正在进行中。随着科布雷项目的成熟，这个核心的人员将分析产生的数据，并在需要时创建新的方法来帮助解释结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This core provides expert advice on experimental design, data management, subject recruitment, and data analysis to the clinical projects in this COBRE and it provides expertise on the analysis of the bioinformatics data generated in the basic science projects. This advice promotes efficiency in terms of the minimal number of patients to be recruited to a clinical study or the minimum number of chips to be processed in a microarray experiment so that information is maximized. Advice rendered at an early stage in the design of the project makes a difference. It also significantly improves the chances that the project will be successful as evidenced by the role this core played in one success in each area. Inherent in this core is a training component since its personnel supervise graduate students trainees in their own discipline and work on a one to one basis with young investigators in the dental sciences. The younger faculty in this core are also mentored by the senior faculty. A journal paper summarizing a pilot project supporting a current clinical project and several abstracts based on related dental graduate student research have been submitted. An R01 application in the basic science area, in which this core provided key technical support, has been awarded and another application is in progress. As the projects in this COBRE mature personnel in this core will analyze the data generated and when needed will create new methodology to help interpret the results.