PLANNING INTERDISCIPLINARY STUDIES OF DIABETIC HEART: PILOT RESEARCH PROJECTS

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。跨学科规划途径小组将开发并开展两个与两条基本发现途径主题相关的具体试点项目。这项练习将作为连接学科和跨越途径的重要手段。这些项目将旨在产生一定数量的候选生物标志物，然后在人体中验证这些标志物；从实验室研究到人群研究。因此，这种方法将需要发现和转化研究以及临床实施途径规划小组成员的广泛投入，并将依赖于技术平台提供的支持。适当项目的例子包括研究特定细胞内脂肪酸中间体作为从小鼠到人类的糖尿病心脏中的毒性介质和疾病严重程度标志物的作用。另一个例子可能涉及一个项目，从病理生物学机制到基于体内纳米颗粒的成像，评估脂质激活核受体在糖尿病血管炎症反应中的作用。从本质上讲，试点项目将作为一个关键机制，将不同的规划小组聚集在一起，形成一个跨学科团队，以解决有限的生物医学问题。此外，跨学科团队的优势和劣势将在项目的规划和执行过程中变得显而易见。研究提案将由理事会审议并批准。试点项目的两个一般阶段如下： 第一阶段：生物标志物的生成和早期验证 第二阶段：开发和验证糖尿病心血管生物标志物组合

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Interdisciplinary Planning Pathway groups will develop and conduct two specific Pilot Projects thematically linked to the two Fundamental Discovery Pathways. This exercise will serve as a critical means of linking disciplines and bridging across the Pathways. The projects will be designed to gererate a select number of candidate biomarkers followed by validation of the markers in humans; from bench-to-population studies. Accordingly, this approach will require the extensive input by members of both the Discovery and Translational Studies and Clinical Implementation Pathway planning groups and will rely on support provided by the Technology Platform. Examples of appropriate projects include studies to investigate the role of specific intracellular fatty acid intermediates as mediators of toxicity and markers of disease severity in the diabetic heart from mouse to human. Another example might involve a project to evaluate the role of lipid-activated nuclear receptors in the diabetic vascular imflammatory response from pathobiologic mechanisms to in vivo nanoparticle-based imaging. In essence, the Pilot Projects will serve as a critical mechanism to bring the distinct planning groups together as an interdisciplinary team to address a circumscribed biomedical problem. In addition, the strengths and weakness of the interdisciplinary teams will become apparent during the planning and execution of the projects. The research proposals will be reviewed and approved by the Council. The two general phases of the pilot projects are as followes: Phase I: Generation of biomarker and early validation Phase II: Develop and validate a Diabetic Cardiovascular Biomarker Pane