PLANNING INTERDISCIPLINARY STUDIES OF DIABETIC HEART: PILOT RESEARCH PROJECTS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。跨学科规划途径小组将开发和实施两个与两个基本发现途径主题相关的具体试点项目。这项工作将成为连接学科和跨越"途径“的重要手段。这些项目的设计目的是筛选出选定数量的候选生物标志物，然后在人体中验证这些标志物;从实验室到人群研究。因此，该方法将需要发现和转化研究以及临床实施途径规划小组成员的广泛投入，并将依赖于技术平台提供的支持。适当项目的例子包括研究特定细胞内脂肪酸中间体作为毒性介质和糖尿病心脏疾病严重程度标志物的作用，从小鼠到人类。另一个例子可能涉及一个项目，以评估脂质激活的核受体在糖尿病血管炎性反应中的作用，从病理生物学机制到基于体内纳米颗粒的成像。从本质上讲，试点项目将作为一个关键机制，将不同的规划小组作为一个跨学科小组聚集在一起，以解决一个有限的生物医学问题。此外，跨学科小组的长处和短处将在项目的规划和执行过程中显现出来。研究建议将由理事会审查和批准。试点项目的两个一般阶段如下：第一阶段：生物标志物的生成和早期验证第二阶段：开发和验证糖尿病心血管生物标志物

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Interdisciplinary Planning Pathway groups will develop and conduct two specific Pilot Projects thematically linked to the two Fundamental Discovery Pathways. This exercise will serve as a critical means of linking disciplines and bridging across the Pathways. The projects will be designed to gererate a select number of candidate biomarkers followed by validation of the markers in humans; from bench-to-population studies. Accordingly, this approach will require the extensive input by members of both the Discovery and Translational Studies and Clinical Implementation Pathway planning groups and will rely on support provided by the Technology Platform. Examples of appropriate projects include studies to investigate the role of specific intracellular fatty acid intermediates as mediators of toxicity and markers of disease severity in the diabetic heart from mouse to human. Another example might involve a project to evaluate the role of lipid-activated nuclear receptors in the diabetic vascular imflammatory response from pathobiologic mechanisms to in vivo nanoparticle-based imaging. In essence, the Pilot Projects will serve as a critical mechanism to bring the distinct planning groups together as an interdisciplinary team to address a circumscribed biomedical problem. In addition, the strengths and weakness of the interdisciplinary teams will become apparent during the planning and execution of the projects. The research proposals will be reviewed and approved by the Council. The two general phases of the pilot projects are as followes: Phase I: Generation of biomarker and early validation Phase II: Develop and validate a Diabetic Cardiovascular Biomarker Pane