Commercialisation potential of a decellularised porcine bladder matrix.

脱细胞猪膀胱基质的商业化潜力。

• 批准号: BB/E527220/1
• 负责人: Jennifer Southgate
• 金额: $ 11.45万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FE527220%2F1
• 关键词: Commercialisation; potential; decellularised; porcine; bladder

We have developed a novel procedure to decellularise full-thickness porcine bladder tissue by utilising the bladder's unique capacity for expansion; a patent is in application. The resultant biometerial is highly stable in its non-cross-linked form, non-cytotoxic in cell culture and retains the strength and compliant properties of the native urinary bladder. Prior to commercialisation, further pre-clinical evaluation of the decellularised porcine bladder tissue is required in order to identify benchmark biomechanical properties, investigate the immunological status and determine whether the biomaterial is able to support both in vitro and in vivo recellularisation. This information is necessary in order to identify specific clinical uses and target appropriate commercialisation sectors.

我们已经开发出一种新的程序，通过利用膀胱独特的扩张能力来使全层猪膀胱组织脱细胞;专利正在申请中。所得生物材料在其非交联形式下高度稳定，在细胞培养中无细胞毒性，并保留天然膀胱的强度和顺应性。在商业化之前，需要对去细胞化猪膀胱组织进行进一步的临床前评价，以确定基准生物力学特性，研究免疫学状态并确定生物材料是否能够支持体外和体内再细胞化。为了确定具体的临床用途和针对适当的商业化部门，这些信息是必要的。

项目成果

Augmentation of the insufficient tissue bed for surgical repair of hypospadias using acellular matrix grafts: A proof of concept study.

使用acellular基质移植物的组织床的不足组织床的外科手术修复：概念研究证明。

• DOI: 10.1177/2041731421998840
• 发表时间: 2021-01
• 期刊: Journal of tissue engineering
• 影响因子: 8.2
• 作者: Morgante D;Radford A;Abbas SK;Ingham E;Subramaniam R;Southgate J
• 通讯作者: Southgate J