UNM COBRE: DIVERSE RECOGNITION CAPABILITY: INVERTEBRATE MODEL

UNM COBRE：多样化的识别能力：无脊椎动物模型

• 批准号: 7382026
• 负责人: SI-MING ZHANG
• 金额: $ 23.44万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382026
• 关键词: UNM; COBRE; DIVERSE; RECOGNITION; CAPABILITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The conventional paradigm of innate immunity suggests that relatively few pattern-recognition receptors (PRRs) are needed for non-self recognition. PRRs are able to recognize highly conserved pathogen-associated molecular patterns (PAMPs) present on the surface of pathogens, no matter how great the differences among the pathogens. Based on the emerging studies from different labs, this view seems incomplete. Our recent work on the diversification of fibrinogen related protein (FREP) genes provides the first evidence in invertebrates for the diversification of innate defense molecules through a novel mechanism. The goal of this project is to study the mechanism of diversification of an immune-related gene (FREP) family in an invertebrate host and to investigate molecular aspects of the interaction between this host and relevant parasites. The specific goals of the project are to determine underlying mechanisms generating diversity of FREP genes observed in our previous investigations, and to develop RNA interference (RNAi) to assess FREP functions. Understanding the mechanism of diversification and function of FREPs will broaden our understanding of invertebrate innate immunity in general and snail internal defense in particular. Ultimately, the study will have benefits for the control of schistosomiasis, a snail-borne disease that affects 200 million people world wide.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。传统的先天免疫范式表明，非自我识别需要相对较少的模式识别受体(PRR)。PRRs能够识别存在于病原体表面的高度保守的病原体相关分子模式(PAMP)，无论病原体之间的差异有多大。根据来自不同实验室的新研究，这一观点似乎并不完整。我们最近在纤维蛋白原相关蛋白(FREP)基因多样性方面的工作为无脊椎动物通过一种新的机制实现天然防御分子的多样化提供了第一个证据。本项目的目标是研究无脊椎动物宿主中免疫相关基因(FREP)家族的多样化机制，并研究该宿主与相关寄生虫相互作用的分子方面。该项目的具体目标是确定在我们之前的研究中观察到的FREP基因多样性的潜在机制，并开发RNA干扰(RNAi)来评估FREP的功能。了解FREPs的多样性和功能机制将拓宽我们对无脊椎动物天然免疫，特别是蜗牛内部防御的理解。最终，这项研究将有利于血吸虫病的控制，血吸虫病是一种由蜗牛传播的疾病，影响着全球2亿人。