COBRE PHASE III: Center for Neuroplasticity at the University of Puerto Rico

COBRE 第三阶段：波多黎各大学神经可塑性中心

• 批准号: 10628974
• 负责人: JOSE Antonio LASALDE-DOMINICCI
• 金额: $ 105.45万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628974
• 关键词: Advisory Committees; Alcohols; Anatomy; Animals; Applications Grants; Area; Award; Basic Science; Benchmarking; Biology; Biomedical Research; Businesses; Centers of Research Excellence; Chemistry; Clinical Research; Collaborations; Communities; Contract Services; Core Facility; Cyclic GMP; Development; Disease; Educational workshop; Electrophysiology (science); Ensure; Entrepreneurship; Faculty; Familiarity; Fees; Floor; Fluorescence; Fostering; Funding; Goals; Grant; IACUC; Image; Industry; Institution; Interdisciplinary Study; Investigation; Investments; Leadership; Medical; Mental disorders; Mentors; Mentorship; Microscope; Microscopy; Molecular; Nerve Degeneration; Neurobiology; Neuronal Plasticity; Neurosciences; Participant; Pharmacology; Pharmacy facility; Phase; Physiology; Pilot Projects; Principal Investigator; Privatization; Productivity; Puerto Rico; Qualifying; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Science; Scientist; Services; Slide; Source; Therapeutic; Training; United States National Institutes of Health; Universities; addiction; biomedical resource; career; design and construction; experience; industry partner; innovation; instrument; instrumentation; medical schools; member; multidisciplinary; multiphoton microscopy; nervous system disorder; neural; neuroadaptation; neuroimaging; neuroprotection; patch clamp; pre-clinical research; preclinical study; programs; recruit; square foot; synergism; translational applications

Project Summary (Overall section): The UPR COBRE Center for Neuroplasticity (UPR-CCfN) was established with a COBRE phase 1 award in 2013 as a collaboration of two main UPR campuses, the Institute of Neurobiology (UPR-MSC) and the Department of Biology at UPR Rio Piedras (UPR-RP). The UPR-CCfN has since expanded collaborations to include several UPR campuses, including the Departments of Biology and Chemistry (UPRRP), Departments of Physiology, Pharmacology, Pharmacy, and Anatomy (UPR-MSC), Department of Chemistry (UPR Humacao campus), and Universidad Central del Caribe Medical School, a private institution in PR. During COBRE phases 1-2 the UPR-CCfN achieved several benchmarks: (1) It has significantly enhanced ability of new and early-stage UPR researchers to conduct competitive research in the area of neuroscience. (2) It has established a critical mass of 24 investigators. (3) It has developed the COBRE Neuroimaging and Electrophysiology Facility (NIEF) core into a state-of-the-art resource for the UPR-CCfN investigators and the larger UPR biomedical research community. This was accomplished by providing outstanding specialized technical services, training, and access to state-of- the-art instrumentation in fluorescence, confocal, and multiphoton microscopy along with electrophysiology that has enhanced the productivity of our researchers. (4) A major accomplishment of the NIEF was becoming a Nikon Center of Excellence (NCoE), globally renowned for its state-of-the- art facilities for advanced research imaging. (5) The UPR-CCfN has extraordinarily increased its biomedical research capacity as it recently took occupancy of a new state-of-the-art research infrastructure, which includes a more than $26 million institutional investment on two floors (~40 square feet) of the Molecular Science Research Center (MSRC); the Neuroplasticity Center (floor 6); and Vivarium (floor 7). (6) UPR-CCfN has developed a robust business plan that will sustain and upgrade our NIEF core facilities, provide technical support, and programmatic activities beyond COBRE Phase 3. During Phase 3 the UPR-CCfN will continue to provide a multidisciplinary cadre of investigators with cutting-edge facilities, scientific capability, and multidisciplinary collaborations with the public and biopharma sectors for the treatment of neurodegeneration-related diseases. The UPR-CCfN will foster research innovation, maximize research synergy and collaborations as well as mentoring and entrepreneurship. Our overreaching goal is that during Phase 3, the UPR-CCfN will propel into a world- recognized Center for Neuroplasticity and Neurodegeneration with translational/therapeutic applications.

项目总结(总体部分)： 成立了UPR Cobre神经可塑性中心(UPR-CCfN)，获得了Cobre第一阶段奖 2013年，作为普遍定期审议两个主要校区的合作，神经生物学研究所(UPR-MSC)和 里约热内卢大学生物系(UPR-RP)。UPR-CCfN自那以来一直在扩大 合作，包括几个普遍定期审议校园，包括生物系和化学系 (UPRRP)，生理学、药理学、药学和解剖学系(UPR-MSC)， 化学系(UPR Humacao校区)和中央加勒比大学医学院， 一家私人公关机构。在Cobre阶段1-2期间，UPR-CCfN实现了几个基准：(1) 它显著提高了新的和早期的普遍定期审议研究人员进行竞争的能力 神经科学领域的研究。(2)它已经建立了24名调查人员的临界数量。(3)它有 将Cobre神经成像和电生理设备(Nef)核心开发为最先进的 为UPR-CCfN调查人员和更大的UPR生物医学研究社区提供的资源。这是 通过提供出色的专业技术服务、培训和访问 最先进的荧光、共聚焦和多光子显微镜仪器以及 电生理学提高了我们研究人员的工作效率。(四)重大成就 成为尼康卓越中心(NCoE)，以其最先进的 先进研究成像的艺术设施。(5)UPR-CCfN异常增加了其 生物医学研究能力，因为它最近占据了一项新的最先进的研究 基础设施，包括两个楼层(约40平方英尺)的2600多万美元机构投资 分子科学研究中心(MSRC)、神经可塑性中心(6楼)；以及 间隔层(7层)。(6)UPR-CCfN制定了稳健的业务计划，将持续和升级 我们的Nef核心设施，提供技术支持，以及超越科布雷阶段的方案活动 3.在第三阶段期间，普遍定期审议--协调委员会将继续向一支多学科调查员队伍提供 尖端的设施、科学能力以及与公众和 治疗神经变性相关疾病的生物医药部门。UPR-CCfN将促进 研究创新，最大限度地实现研究协同和协作，以及指导和 企业家精神。我们超越的目标是，在第三阶段，UPR-CCfN将推动进入一个- 公认的神经可塑性和神经变性中心与翻译/治疗 申请。