COBRE PHASE III: Center for Neuroplasticity at the University of Puerto Rico

COBRE 第三阶段：波多黎各大学神经可塑性中心

• 批准号: 10628974
• 负责人: JOSE Antonio LASALDE-DOMINICCI
• 金额: $ 105.45万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628974
• 关键词: Advisory Committees; Alcohols; Anatomy; Animals; Applications Grants; Area; Award; Basic Science; Benchmarking; Biology; Biomedical Research; Businesses; Centers of Research Excellence; Chemistry; Clinical Research; Collaborations; Communities; Contract Services; Core Facility; Cyclic GMP; Development; Disease; Educational workshop; Electrophysiology (science); Ensure; Entrepreneurship; Faculty; Familiarity; Fees; Floor; Fluorescence; Fostering; Funding; Goals; Grant; IACUC; Image; Industry; Institution; Interdisciplinary Study; Investigation; Investments; Leadership; Medical; Mental disorders; Mentors; Mentorship; Microscope; Microscopy; Molecular; Nerve Degeneration; Neurobiology; Neuronal Plasticity; Neurosciences; Participant; Pharmacology; Pharmacy facility; Phase; Physiology; Pilot Projects; Principal Investigator; Privatization; Productivity; Puerto Rico; Qualifying; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Science; Scientist; Services; Slide; Source; Therapeutic; Training; United States National Institutes of Health; Universities; addiction; biomedical resource; career; design and construction; experience; industry partner; innovation; instrument; instrumentation; medical schools; member; multidisciplinary; multiphoton microscopy; nervous system disorder; neural; neuroadaptation; neuroimaging; neuroprotection; patch clamp; pre-clinical research; preclinical study; programs; recruit; square foot; synergism; translational applications

Project Summary (Overall section): The UPR COBRE Center for Neuroplasticity (UPR-CCfN) was established with a COBRE phase 1 award in 2013 as a collaboration of two main UPR campuses, the Institute of Neurobiology (UPR-MSC) and the Department of Biology at UPR Rio Piedras (UPR-RP). The UPR-CCfN has since expanded collaborations to include several UPR campuses, including the Departments of Biology and Chemistry (UPRRP), Departments of Physiology, Pharmacology, Pharmacy, and Anatomy (UPR-MSC), Department of Chemistry (UPR Humacao campus), and Universidad Central del Caribe Medical School, a private institution in PR. During COBRE phases 1-2 the UPR-CCfN achieved several benchmarks: (1) It has significantly enhanced ability of new and early-stage UPR researchers to conduct competitive research in the area of neuroscience. (2) It has established a critical mass of 24 investigators. (3) It has developed the COBRE Neuroimaging and Electrophysiology Facility (NIEF) core into a state-of-the-art resource for the UPR-CCfN investigators and the larger UPR biomedical research community. This was accomplished by providing outstanding specialized technical services, training, and access to state-of- the-art instrumentation in fluorescence, confocal, and multiphoton microscopy along with electrophysiology that has enhanced the productivity of our researchers. (4) A major accomplishment of the NIEF was becoming a Nikon Center of Excellence (NCoE), globally renowned for its state-of-the- art facilities for advanced research imaging. (5) The UPR-CCfN has extraordinarily increased its biomedical research capacity as it recently took occupancy of a new state-of-the-art research infrastructure, which includes a more than $26 million institutional investment on two floors (~40 square feet) of the Molecular Science Research Center (MSRC); the Neuroplasticity Center (floor 6); and Vivarium (floor 7). (6) UPR-CCfN has developed a robust business plan that will sustain and upgrade our NIEF core facilities, provide technical support, and programmatic activities beyond COBRE Phase 3. During Phase 3 the UPR-CCfN will continue to provide a multidisciplinary cadre of investigators with cutting-edge facilities, scientific capability, and multidisciplinary collaborations with the public and biopharma sectors for the treatment of neurodegeneration-related diseases. The UPR-CCfN will foster research innovation, maximize research synergy and collaborations as well as mentoring and entrepreneurship. Our overreaching goal is that during Phase 3, the UPR-CCfN will propel into a world- recognized Center for Neuroplasticity and Neurodegeneration with translational/therapeutic applications.

项目摘要（总体部分）： 建立了UPR COBRE神经塑性中心（UPR-CCFN），并获得了COBRE 1阶段奖 2013年，作为两个主要UPR校园的合作，神经生物学研究所（UPR-MSC）和 UPR Rio Piedras（UPR-RP）生物学系。此后，UPR-CCFN扩展了 合作以包括几个UPR校园，包括生物学和化学部门 （UPRP），生理学，药理学，药房和解剖学部（UPR-MSC）， 化学系（UPR Humacao校园）和Central Del Caribe医学院 公关中的私人机构。在毛线阶段1-2期间，UPR-CCFN实现了几个基准：（1） 它具有新的和早期UPR研究人员进行竞争性的能力明显提高 神经科学领域的研究。 （2）它已经建立了24个研究人员的临界质量。 （3）有 开发了圆锥神经影像学和电生理学设施（NIEF）核心 UPR-CCFN研究人员和较大的UPR生物医学研究界的资源。这是 通过提供出色的专业技术服务，培训和访问权限来完成 荧光，共聚焦和多光子显微镜的艺术仪器以及 电生理学增强了我们的研究人员的生产力。 （4）一项重大成就 尼夫（Nief）成为尼康卓越中心（NCOE），以其最先进的方式闻名 高级研究成像的艺术设施。 （5）UPR-CCFN非常增加 生物医学研究能力最近占用了一项新的最先进的研究 基础设施，其中包括两层超过2600万美元的机构投资（〜40平方英尺） 分子科学研究中心（MSRC）的脚；神经可塑性中心（6楼）；和 Vivarium（7楼）。 （6）UPR-CCFN制定了一项强大的商业计划，可以维持和升级 我们的NIEF核心设施，提供技术支持和越界以外的程序化活动 3。在第3阶段，UPR-CCFN将继续为研究人员提供多学科干部 尖端的设施，科学能力以及与公众的多学科合作 用于治疗神经退行性疾病的生物制药部门。 UPR-CCFN将培养 研究创新，最大化研究协同和协作以及指导和指导 企业家精神。我们的超越目标是，在第3阶段，UPR-CCFN将推动进入世界 - 公认的神经塑性和神经变性中心，具有转化/治疗性 申请。