COBRE Center for Central Nervous System Function

COBRE 中枢神经系统功能中心

• 批准号: 10630553
• 负责人: JEROME N SANES
• 金额: $ 119.63万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630553
• 关键词: Applications Grants; Award; Behavior; Biological Models; Biology; Brain; Brain Diseases; Centers of Research Excellence; Central Nervous System; Communities; Computational Biology; Core Facility; Country; Data Analyses; Disease model; Ensure; Environment; Experimental Designs; Faculty; Functional Magnetic Resonance Imaging; Funding; Generations; Goals; Grant; Growth; High Performance Computing; Hospitals; Human; Human Characteristics; Hybrids; Japan; Journals; K-Series Research Career Programs; Leadership; Link; Magnetic Resonance Imaging; Mentors; Mission; National Institute of General Medical Sciences; Nervous System Physiology; Neurons; Neurosciences; Neurosciences Research; Outcome; Paper; Peer Review; Performance; Phase; Phase Transition; Pilot Projects; Positioning Attribute; Pre-Clinical Model; Privatization; Publications; Publishing; Records; Research; Research Infrastructure; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Research Support; Research Technics; Resources; Rhode Island; Rodent; Science; Scientist; Services; System; United States; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Vision; Work; Writing; behavioral phenotyping; brain health; career; cluster computing; cognitive enhancement; cohort; design; member; neuroimaging; novel; outreach services; programs; research facility; success

The long-term goal of the COBRE Center for Central Nervous System Function is to develop a neuroscience research center that provides research support to a wide array of neuroscience researchers at Brown University and its affiliated hospitals and the Rhode Island neuroscience research community. Since we began our COBRE in 2013, we have supported 13 Project Leaders and nine Pilot Project Leaders as they developed their research and academic careers. Collectively, our supported cohort has been awarded nearly 20 R01 or equivalent research grants, which along with other awarded grants has yielded more than $50 million in external funding. Grants relevant to our COBRE received by members of our Research Cores have totaled another $4 million. Of the 11 Project Leaders who served two or more years, nine have successfully graduated, with a tenth having received positive reviews of an R01 grant proposal. Collectively, our COBRE supported scientists have published nearly 130 peer-reviewed papers citing COBRE support and more than 400 papers overall. These papers have appeared in prestigious journals, including Nature Human Behavior, Current Biology, Neuron, eLife, PLoS Computational Biology, Journal of Neuroscience and other field-specific journals. We have developed a research core to assist our community in best practices for experimental design and data analysis. The main objective for Phase 3 COBRE support relates to building-out our research core to serve the needs of the neuroscience community at Brown and Rhode Island and also to expand and strengthen our Pilot Project Program. We will enhance the scope of our Research Core by integrating two existing neuroscience core facilities, the MRI Research Facility and the Rodent Behavior Phenotyping Core, into one administrative entity. Additionally, we will partner with service cores of other local COBREs and those at Brown-affiliated hospitals to broaden our service outreach. Our vision is that by sustaining and transitioning the established research infrastructure into an integrated entity, we will enable neuroscientists to conduct their work more effectively and efficiently.

COBRE中枢神经系统功能中心的长期目标是发展神经科学 研究中心，为布朗大学的一系列神经科学研究人员提供研究支持 大学及其附属医院和罗得岛神经科学研究界。自从我们开始 在2013年的COBRE中，我们支持了13个项目负责人和9个试点项目负责人， 他们的研究和学术生涯。总的来说，我们支持的队列已获得近20个R01或 同等的研究赠款，其中沿着与其他授予的赠款已产生超过5000万美元， 外部资金。我们的研究核心成员收到的与我们的COBRE相关的赠款总计 另外四百万。在任职两年或两年以上的11名项目负责人中，有9人成功毕业， 其中十分之一已经收到了R01赠款提案的积极评价。总的来说，我们的COBRE支持 科学家们已经发表了近130篇引用COBRE支持的同行评审论文，以及400多篇论文 总的来说。这些论文发表在著名的期刊上，包括《自然人类行为》、《当代 Biology、Neuron、eLife、PLoS Computational Biology、Journal of Neuroscience和其他特定领域的期刊。 我们已经开发了一个研究核心，以帮助我们的社区在实验设计和 数据分析第三阶段COBRE支持的主要目标是扩大我们的研究核心， 满足布朗和罗得岛神经科学界的需求，并扩大和 加强我们的试点项目。我们将加强我们的研究核心的范围，通过整合两个 现有的神经科学核心设施，MRI研究设施和啮齿动物行为表型核心， 成为一个行政实体。此外，我们还将与其他本地COBREs的服务核心合作， 扩大我们的服务范围我们的愿景是，通过维持和过渡 将现有的研究基础设施整合为一个综合实体，我们将使神经科学家能够进行他们的研究。 更有效和高效地工作。