COBRE: UNE MED CTR: CORE C: HISTOLOGY CORE

COBRE：UNE MED CTR：核心 C：组织学核心

• 批准号: 7382089
• 负责人: Claudia T Kappen
• 金额: $ 14.14万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382089
• 关键词: COBRE; UNE; MED; CTR; CORE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Histology Core has the mission to serve the investigators of the COBRE Program with their needs in specialized morphological and histological analysis of neurosensory development and relevant mouse phenotypes. A Core Facility for histology offers several advantages to the COBRE investigators and the COBRE Program: 1) Enrichment of Resources: The establishment of the Core Facility with expert personnel will provide the individual investigators with a multitude of services, equipment resources and technical expertise that is not readily available within their individual laboratories. This will significantly broaden the depth of the individual research projects and support the development of state-of-the-art and technologically comprehensive research programs within the individual junior investigators' laboratories. 2) Efficiency of Personnel and Cost Management: The concentration of such resources within the Core allows for better efficiency and standardization in the usage of typically costly reagents, such as for example, specialized antibodies. Furthermore, the involvement of the highly trained and experienced Director of Phenotyping Services at UNMC, Ms. M. Anita Jennings, will reduce the need for each PI to allocate their personnel to methodologies that require extensive training and time in order to be proficiently carried out. In addition, the use of common reagents will better allow investigators from the different laboratories to compare and interpret results. 3) Quality Assurance, Mentoring and Information Flow: Scientifically, the Core will enable a standardization of procedures, of flow of information, and of frameworks for interpretation that will greatly enhance the infrastructure for success of individual projects through common quality assurance, data generation and interpretation standards. In this way, investigators benefit from the combined expertise generated through all of the projects. Most importantly, information flow will be improved through the use of a common Website for access to the Histology Core that integrates the efforts of individual investigators along common themes. 4) Enhancement of Infrastructure: The long-term objective of the COBRE, namely, to establish a critical mass of investigators on one area through the Center for Neurosensory Development in Nebraska, will also be served by the Core Facility. The availability of a specialized Histology Core Facility will increase the competitiveness of COBRE investigators for extramural funding, serve in retention of funded investigators, and attract and recruit new investigators into the Center for Neurosensory Development.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。组织学核心的使命是在神经感觉发育和相关小鼠表型的专业形态学和组织学分析中为毛to计划的研究者提供他们的需求。组织学的核心设施为毛毛调查人员和山核桃计划提供了几个优势：1）丰富资源：建立核心设施由专家人员为个人调查人员提供多种服务，设备资源和技术专长，而在其个人实验室内不易获得。这将大大扩大个别研究项目的深度，并支持各个初级研究人员实验室中最先进和技术全面的研究计划的发展。 2）人员和成本管理的效率：此类资源在核心中的集中度允许在使用通常昂贵的试剂（例如专用抗体）中提高效率和标准化。此外，M. Anita Jennings女士在UNMC的表型服务训练有素且经验丰富的表型主管的参与将减少每个PI将其人员分配给需要广泛培训和时间才能熟练进行的方法论的需求。此外，使用常见试剂将更好地允许来自不同实验室的研究人员比较和解释结果。 3）质量保证，指导和信息流：从科学上讲，核心将使程序，信息流以及解释框架的标准化，这将通过共同的质量保证，数据生成和解释标准大大增强单个项目成功的基础设施。这样，调查人员受益于通过所有项目产生的综合专业知识。最重要的是，通过使用通用网站访问组织核心的组织核心将改善信息流，该组织核心将单个研究人员纳入共同主题的努力。 4）基础设施的增强：毛毛的长期目标，即通过内布拉斯加州神经感觉开发中心在一个地区建立一大批研究人员，也将由核心设施提供服务。专业组织学核心设施的可用性将提高毛cre研究者在校外资金中的竞争力，服务于资助的研究人员，并吸引并招募新的研究人员进入神经感觉开发中心。