COBRE: UNE MED CTR: CORE C: HISTOLOGY CORE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。组织学核心的使命是为COBRE计划的研究人员提供服务，满足他们对感觉神经发育和相关小鼠表型的专门形态学和组织学分析的需求。组织学核心设施为COBRE研究人员和COBRE计划提供了几个优势：1）丰富资源：建立具有专家人员的核心设施将为个体研究人员提供大量服务，设备资源和技术专业知识，这些在他们的个体实验室中是不容易获得的。这将大大拓宽个人研究项目的深度，并支持在个人初级研究人员实验室内开发最先进和技术全面的研究方案。2)人员和成本管理的效率：将这些资源集中在核心内允许在使用通常昂贵的试剂（例如，专门的抗体）时具有更好的效率和标准化。此外，联合国监测委员会表型鉴定处处长M. Anita Jennings将减少每个PI将其人员分配到需要大量培训和时间才能熟练执行的方法的需要。此外，使用通用试剂将使来自不同实验室的研究人员能够更好地比较和解释结果。3)质量保证、指导和信息流动：科学的核心将使程序、信息流动和解释框架标准化，通过共同的质量保证、数据生成和解释标准，大大加强单个项目成功的基础设施。通过这种方式，调查人员从所有项目产生的综合专门知识中受益。最重要的是，通过使用一个共同的网站访问组织学核心，信息流动将得到改善，该网站将各个研究者的努力沿着共同的主题进行整合。4)加强基础设施：COBRE的长期目标，即通过内布拉斯加州的神经感觉发育中心在一个领域建立足够数量的研究人员，也将由核心设施提供服务。一个专门的组织学核心设施的可用性将提高COBRE研究者的竞争力，以获得校外资金，保留资助的研究者，并吸引和招募新的研究者进入神经感觉发育中心。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Histology Core has the mission to serve the investigators of the COBRE Program with their needs in specialized morphological and histological analysis of neurosensory development and relevant mouse phenotypes. A Core Facility for histology offers several advantages to the COBRE investigators and the COBRE Program: 1) Enrichment of Resources: The establishment of the Core Facility with expert personnel will provide the individual investigators with a multitude of services, equipment resources and technical expertise that is not readily available within their individual laboratories. This will significantly broaden the depth of the individual research projects and support the development of state-of-the-art and technologically comprehensive research programs within the individual junior investigators' laboratories. 2) Efficiency of Personnel and Cost Management: The concentration of such resources within the Core allows for better efficiency and standardization in the usage of typically costly reagents, such as for example, specialized antibodies. Furthermore, the involvement of the highly trained and experienced Director of Phenotyping Services at UNMC, Ms. M. Anita Jennings, will reduce the need for each PI to allocate their personnel to methodologies that require extensive training and time in order to be proficiently carried out. In addition, the use of common reagents will better allow investigators from the different laboratories to compare and interpret results. 3) Quality Assurance, Mentoring and Information Flow: Scientifically, the Core will enable a standardization of procedures, of flow of information, and of frameworks for interpretation that will greatly enhance the infrastructure for success of individual projects through common quality assurance, data generation and interpretation standards. In this way, investigators benefit from the combined expertise generated through all of the projects. Most importantly, information flow will be improved through the use of a common Website for access to the Histology Core that integrates the efforts of individual investigators along common themes. 4) Enhancement of Infrastructure: The long-term objective of the COBRE, namely, to establish a critical mass of investigators on one area through the Center for Neurosensory Development in Nebraska, will also be served by the Core Facility. The availability of a specialized Histology Core Facility will increase the competitiveness of COBRE investigators for extramural funding, serve in retention of funded investigators, and attract and recruit new investigators into the Center for Neurosensory Development.