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Sex-Specific Pathways Linking Stress and Drug Abuse

连接压力和药物滥用的性别特异性途径

基本信息

批准号：
7369728
负责人：
Rajita Sinha
金额：
$ 12.73万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-04-15 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7369728
关键词：
Acute Area Arousal Award Catecholamines Chronic Clinical Cocaine Cocaine Dependence Communities Cues Development Development Plans Disease Drug Addiction Drug abuse Drug usage Early-life trauma Educational Curriculum Emotions Employment Event Extramural Activities Family Funding Funding Mechanisms Gender Grant HPSE gene Health Hydrocortisone Imagery Independent Scientist Award Individual Differences Inpatients Joints Laboratories Life Life Stress Linear Models Link Major Depressive Disorder Measures Methods Modeling Morbidity - disease rate National Institute of Drug Abuse Neurobiology Pathway interactions Peer Review Personality Pharmaceutical Preparations Physiological Plasma Post-Traumatic Stress Disorders Productivity Publications Rate Relapse Research Research Personnel Research Project Grants Risk Sampling Severities Sex Characteristics Source Specialized Center Stimulus Stress Surveys TNFRSF5 gene Time Training United States National Institutes of Health Wages Woman Women&apos s Health Work career coping craving drug craving drug relapse emotional abuse experience hypothalamic-pituitary-adrenal axis improved men multidisciplinary negative mood programs psychobiologic psychologic response sex skills social stress stressor symposium tool

项目摘要

DESCRIPTION (provided by applicant): This K02 application seeks support which is essential for my continued career development as a newly independent clinical researcher. Funded by a joint NIH Office of Research on Women's Health (ORWH) and NIDA institutional training grant (K12-DA14038; PI: Carolyn Mazure, Program Director: Bruce Rounsaville), I have attained substantial experience in examining sex differences in the association between stress and drug abuse over the past 3 years. I have demonstrated considerable research productivity as evidenced by my peer-reviewed publications, my scientific directorship of a Women's Health Specialized Center of Research (SCOR) on sex, stress and cocaine addiction (P50-DA16556, PI: Sinha), my principal and co-principal investigatorships on two center sections, a previous NIDA funded R01 (R01-DA11077, PI: Sinha) and a recently awarded R01 (AA13892, PI: Sinha). However, this source of salary support (75%) will expire by 12/31/03, leading me to seek an alternative mechanism of funding. Therefore, this K02 award is vital for sustaining my current full-time research focus and for facilitating my development into a fully independent investigator. Justification for the award is provided by a comprehensive 5-year Career Development Plan that fills important gaps in my current expertise in sex-specific factors in the neurobiology of stress and drug relapse. Specifically, I will acquire specialized skills in several additional multidisciplinary areas: (a) basic sex-specific neurobiology of stress and drug addiction; (b) pharmacological and psychological methods to study stress and drug craving states; and (c) advanced bio-statistical tools such as mixed linear models and random effects models. Intensive training is provided by an integrated curriculum of intramural coursework, extramural didactics, individualized preceptorships, interactive symposia, and research-related organizational meetings on drug abuse and women's health. A representative research project (P50-DA16556, Center Project PI: R. Sinha) is included, which will examine, (1) sex differences in the subjective, autonomic and HPA response to stress and to drug cues as compared to neutral cues in cocaine dependent men and women, and (2) sex differences in the association between early trauma, stressful life events, acute psychobiological responses to stress and to drug cues and cocaine relapse. This research project along with additional lines of research that I am conducting illustrates the significant impact this career award will have in furthering not only my scientific career, but also our fundamental understanding of how stress increases the risk of drug relapse differentially in men and women. Such an understanding will have important implications for the development of gender-specific treatments for cocaine dependence that will ultimately improve the health of cocaine-addicted women and their families.

描述（由申请人提供）：此 K02 申请寻求支持，这对于我作为新独立临床研究员的持续职业发展至关重要。在 NIH 妇女健康研究办公室 (ORWH) 和 NIDA 机构培训基金（K12-DA14038；PI：Carolyn Mazure，项目总监：Bruce Rounsaville）的联合资助下，我在过去 3 年里在研究压力与药物滥用之间的性别差异方面获得了丰富的经验。我的同行评审出版物、我在性、压力和可卡因成瘾方面的妇女健康专业研究中心 (SCOR) 的科学主任（P50-DA16556，PI：Sinha）、我在两个中心部门的主要和联合主要研究职位、之前 NIDA 资助的 R01（R01-DA11077，PI：Sinha）都证明了我具有相当高的研究生产力。 Sinha）和最近获得的 R01（AA13892，PI：Sinha）。然而，这种工资支持来源 (75%) 将于 2003 年 12 月 31 日到期，导致我寻求替代的资金机制。因此，这个 K02 奖项对于维持我目前的全职研究重点并促进我发展成为一名完全独立的研究者至关重要。获得该奖项的理由是一项全面的五年职业发展计划，该计划填补了我目前在压力和药物复发的神经生物学中的性别特异性因素方面的专业知识的重要空白。具体来说，我将获得几个额外的多学科领域的专业技能：（a）压力和毒瘾的基本性别特异性神经生物学； (b) 研究压力和药物渴望状态的药理学和心理学方法； (c) 先进的生物统计工具，例如混合线性模型和随机效应模型。强化培训由校内课程、校外教学、个性化指导、互动研讨会以及与药物滥用和妇女健康研究相关的组织会议组成的综合课程提供。其中包括一个代表性研究项目（P50-DA16556，中心项目负责人：R. Sinha），该项目将检查：（1）与可卡因依赖男性和女性的中性线索相比，对压力和药物线索的主观、自主和 HPA 反应的性别差异，以及（2）早期创伤、压力生活事件、对压力和药物线索和可卡因的急性心理生物学反应之间关联的性别差异复发。这个研究项目以及我正在进行的其他研究表明，这个职业奖项不仅对促进我的科学事业产生重大影响，而且对我们对压力如何不同地增加男性和女性药物复发风险的基本理解产生影响。这种理解将对开发针对可卡因依赖的针对性别的治疗方法产生重要影响，从而最终改善可卡因成瘾妇女及其家人的健康。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Sex steroid hormones, stress response, and drug craving in cocaine-dependent women: implications for relapse susceptibility.

可卡因依赖女性的性类固醇激素、压力反应和药物渴望：对复发易感性的影响。

DOI：
10.1037/1064-1297.15.5.445
发表时间：
2007
期刊：
Experimental and clinical psychopharmacology
影响因子：
2.3
作者：
Sinha,Rajita;Fox,Helen;Hong,Kwang-Ik;Sofuoglu,Mehmet;Morgan,PeterT;Bergquist,KenT
通讯作者：
Bergquist,KenT

HPA axis response to psychological stress and treatment retention in residential substance abuse treatment: a prospective study.