Epidemiologic Studies of Alcohol Use Disorders (ongoing)

描述（由申请人提供）：酒精滥用和依赖是美国和世界范围内重大的公共卫生问题。澄清这些问题的发病和慢性原因是一项高度科学优先事项，制定切实有效的干预措施也是一项高度科学优先事项。这是为Deborah Hasin博士申请的K05研究科学家奖，目的是为Hasin博士提供5年的持续支持，以继续和扩大她在酒精中毒研究中的领导作用。这将通过K05从教学和行政职责中解脱出来来实现，使Hasin博士能够继续专注于她的研究和指导，这是一个非常高水平的科学成就和生产力的特点。在K05奖期间，哈辛博士建议继续她在哥伦比亚大学（梅尔曼公共卫生学院，流行病学系和内科和外科医生学院，精神病学系）的研究项目。哈辛博士的研究主要集中在四个领域。(1)普通人群中酒精使用障碍概念的有效性以及这些障碍的自然历史。(2)重度抑郁症与酒精和药物使用障碍的关系。哈辛博士的工作回答了这两个领域的一些主要问题，并继续解决重要的遗留问题。(3)基因-环境相互作用。以色列人口亚群在接触饮酒环境和饮酒方面存在差异。通过研究最近俄罗斯移民到以色列和其他以色列人的酒精代谢基因、酒精消费和依赖程度，哈辛博士发现了一个独特的机会，可以在截然不同的环境条件下研究特定的基因（背景人均酒精消费水平）。哈辛博士在这一领域的工作被认为对酒精基因环境研究的未来方向至关重要。哈辛博士还将继续开发一个新的领域。(4)对HIV初级保健患者不安全饮酒的简短干预。哈辛博士将与哥伦比亚大学和其他地方的专家一起开展多方面的研究项目。K05计划还包括继续参与国内和国际科学活动，扩大哈辛博士的指导和科学教育。通过解除哈辛博士的其他职责，K05奖将使哈辛博士能够保持她对酒精中毒研究领域的杰出贡献。

DESCRIPTION (provided by applicant): Alcohol abuse and dependence are significant public health problems in the U.S. and worldwide. Clarifying the causes for onset and chronicity of these problems is a high scientific priority, as is the development of practical, effective interventions. This is an application for a K05 Research Scientist Award for Deborah Hasin, Ph.D. The purpose is to provide 5 years of ongoing support for Dr. Hasin to continue and expand her leadership role in alcoholism research. This will be achieved through the K05 release from teaching and administrative duties, allowing Dr. Hasin to continue to concentrate on her research and mentoring, which is characterized by a very high level of scientific accomplishment and productivity. During the K05 award, Dr. Hasin proposes to continue her research program at Columbia University (Mailman School of Public Health, Department of Epidemiology and College of Physicians and Surgeons, Department of Psychiatry). Dr. Hasin's research has focused on four main areas. (1) The validity of concepts of alcohol use disorders in the general population and the natural history of those disorders. (2) The relationship of major depression to alcohol and drug use disorders. Dr. Hasin's work has answered some of the main questions in these two areas, and continues to address important remaining issues. (3) Gene-environment interaction. Israeli population subgroups differ in their exposures to drinking environments and in their drinking. By studying alcohol metabolizing genes, alcohol consumption, and dependence severity in recent Russian immigrants to Israel and other Israelis, Dr. Hasin has identified a unique opportunity to study specific genes under sharply contrasting environmental circumstances (background per capita alcohol consumption levels). Dr. Hasin's work in this area has been described as critical for future directions in gene-environment studies of alcohol. Dr. Hasin will also continue to develop a newer area. (4) Brief intervention for unsafe drinking among patients in HIV primary care. Dr. Hasin will conduct her multifaceted program of research with experts at Columbia University and elsewhere. The K05 plan also includes continued participation in national and international scientific activities, and expansion of Dr. Hasin's mentoring and science education. By releasing Dr. Hasin from other responsibilities, the K05 award will allow Dr. Hasin to maintain her outstanding level of contribution to the field of alcoholism research.