Load-Driven Bone Lengthening

负载驱动的骨延长

基本信息

  • 批准号:
    7513232
  • 负责人:
  • 金额:
    $ 7.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-08-04 至 2011-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The long-term objective of the proposed project is to understand the mechanism of load-driven bone lengthening. Although distraction osteogenesis is effective to treat the patients with limb length discrepancy, this invasive procedure occasionally generates problems such as premature consolidation, delayed union, and infection. In order to investigate a possibility of load-driven non-invasive therapy, we will focus on knee loading a form of joint loading modalities. In this R03 project, we address a set of questions: (1) Does knee loading enhance proliferation of chondrocytes in the growth plate and lengthen the proliferative and hypertrophic zones in the distal femur and the proximal tibia? (2) Is the lengthening effect dependent on ages? (3) Does injection of insulin growth factor-2 (IGF-2) into the growth plate enhance the loading effects? We hypothesize: (a) Lateral loads, applied to the knee with appropriate loading conditions, can lengthen both the femur and the tibia through stimulating proliferation of chondrocytes in the growth plate; (b) Efficacy of load-driven bone lengthening is stronger in the youth than the elderly; and (c) The lengthening effect can be augmented in the elderly by injecting IGF-1 in the growth plate. In order to examine the above hypotheses, three specific aims are proposed using a hindlimb of C57BL/6 mice as a model system. " Evaluation of load-driven bone lengthening under varying mechanical conditions " Comparison of the loading effects among mice with varying ages " Effects of local administration of IGF-2 into the growth plate with and without knee loading. We will use a custom-made piezoelectric mechanical loader, and conduct bone histomorphometric and gene expression analyses using varying imaging modalities. The proposed study is expected to contribute to developing a non-invasive physical therapy for treatment of patients with limb length discrepancy. PROJECT NARRATIVE Currently the invasive surgical procedure (distraction osteogenesis) is commonly employed to lengthen long bones. However, this procedure presents a series of potential risks such as premature consolidation, delayed union, bone infection, joint stiffness, and fracture of newly formed bone. The proposed R03 project will contribute to examining a possibility of non-invasive physical therapy for treatment of patients with limb length discrepancy.
描述(由申请人提供):

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Ping Zhang其他文献

毛细管电泳差分非接触电导检测器测定氨基酸
  • DOI:
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    6.1
  • 作者:
    Yaolong Li;Zhenli Zhang;Ping Zhang;Qi Kang
  • 通讯作者:
    Qi Kang

Ping Zhang的其他文献

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{{ truncateString('Ping Zhang', 18)}}的其他基金

IMPORTANCE OF PERIODONTITIS IN THE INNATE IMMUNE REGULATION OF ALZHEIMER'S DISEASE
牙周炎在阿尔茨海默病先天免疫调节中的重要性
  • 批准号:
    10658447
  • 财政年份:
    2023
  • 资助金额:
    $ 7.55万
  • 项目类别:
ROLE OF OSTEOCLAST PRECURSORS IN PERIODONTAL BONE LOSS
破骨细胞前体在牙周骨丢失中的作用
  • 批准号:
    9381236
  • 财政年份:
    2017
  • 资助金额:
    $ 7.55万
  • 项目类别:
ROLE OF OSTEOCLAST PRECURSORS IN PERIODONTAL BONE LOSS
破骨细胞前体在牙周骨丢失中的作用
  • 批准号:
    10201568
  • 财政年份:
    2017
  • 资助金额:
    $ 7.55万
  • 项目类别:
Molecular mechanisms of the innate regulation of osteoclastogenesis.
破骨细胞生成先天调节的分子机制。
  • 批准号:
    8488432
  • 财政年份:
    2012
  • 资助金额:
    $ 7.55万
  • 项目类别:
Molecular mechanisms of the innate regulation of osteoclastogenesis.
破骨细胞生成先天调节的分子机制。
  • 批准号:
    8383398
  • 财政年份:
    2012
  • 资助金额:
    $ 7.55万
  • 项目类别:
Load-Driven Bone Lengthening
负载驱动的骨延长
  • 批准号:
    7847554
  • 财政年份:
    2008
  • 资助金额:
    $ 7.55万
  • 项目类别:
Load-Driven Bone Lengthening
负载驱动的骨延长
  • 批准号:
    7670257
  • 财政年份:
    2008
  • 资助金额:
    $ 7.55万
  • 项目类别:
Mechanistic Analyses of kinase signaling complexes
激酶信号复合物的机制分析
  • 批准号:
    10486948
  • 财政年份:
  • 资助金额:
    $ 7.55万
  • 项目类别:
Mechanistic Analyses of kinase signaling complexes
激酶信号复合物的机制分析
  • 批准号:
    10926302
  • 财政年份:
  • 资助金额:
    $ 7.55万
  • 项目类别:
Structual and function of kinase signaling complexes
激酶信号复合物的结构和功能
  • 批准号:
    10262432
  • 财政年份:
  • 资助金额:
    $ 7.55万
  • 项目类别:

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