REUSABLE STORAGE PHOSPHOR FOR ADVANCED RADIATION THERAPY DOSIMETRY

用于高级放射治疗剂量测定的可重复使用的存储荧光粉

• 批准号: 7359793
• 负责人: Harold Hui Li
• 金额: $ 20.52万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-15 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7359793
• 关键词: Applications Grants; Arts; Biomedical Engineering; Characteristics; Clinic; Clinical; Data; Defect; Dependence; Development; Devices; Dose; Dose-Rate; Electron Beam; Electronics; Europium; Feedback; Film; Fluorescence; Funding Mechanisms; Goals; Image; Intensity-Modulated Radiotherapy; Light; Liquid substance; Measurement; Measures; Methods; Monitor; NIH Program Announcements; Numbers; Output; Particle Size; Photons; Plasticizers; Polymers; Potassium Chloride; Powder dose form; Process; Production; Property; Radiation Oncology; Radiation therapy; Radiology Specialty; Range; Reproducibility; Research; Resolution; Roentgen Rays; Sampling; Scanning Electron Microscopy; Signal Transduction; Solvents; Standards of Weights and Measures; Suspension substance; Suspensions; System; Techniques; Temperature; Thick; Time; Validation; Water; Weight; X ray diffraction analysis; X-Ray Diffraction; X-Ray Film; abstracting; base; clinically relevant; dosimetry; follow-up; improved; luminescence; novel; particle; prototype; response; treatment planning; two-dimensional

DESCRIPTION (provided by applicant): Reusable storage phosphor for radiation therapy dosimetry. Abstract Modern radiation therapy has advanced considerably in the last decade with the development of improved imaging and conformal dose delivery techniques. With the subsequent increased complexity of treatment planning and dose delivery, there has been growing demand for multi-dimensional quantitative dose delivery validation. Radiographic film has become the de facto standard for two-dimensional dose distribution measurements. As clinics move towards electronic imaging, the film processors that are critical for radiographic film use are being removed. Multi-point electronic dosimeters have recently been introduced and are being used for dose distribution validation. While the use of these devices is fast and convenient, they are limited to measuring single planes oriented normal to the incident beams and cannot be used in most geometric phantoms, the use of which are critical to treatment planning system commissioning. In addition to the measurement dimensionality, an important operating characteristic for dosimeters is the user's ability to characterize and monitor the dosimeter response. This has been possible with multipoint electronic dosimeters, but not higher-resolution single-use dosimeters such as radiographic or radiochromic film. We propose to develop a novel, reusable, high-resolution two-dimensional dosimeter with an effective atomic number (Z) close to water. This dosimeter will be a storage phosphor plate (SPP) consisting of low Z storage phosphor particles dispersed in a polymer binder. Our first aim is to develop a process for preparing low Z storage phosphor powders. Our second aim is to quantify the dosimetric properties and optimize the phosphor production process developed in aim 1. Our third aim is to produce a prototype SPP using a state-of-the-art tape-casting method. The successful completion of these specific aims will provide a quantitative two-dimensional dosimeter that can be used in existing geometric phantoms and that can be reused so that the dosimetry characteristics can be determined and monitored by the physicist.

描述（由申请人提供）：用于放射治疗剂量测定的可重复使用存储磷光体。 摘要现代放射治疗在过去的十年中取得了很大的进步，随着成像技术和适形剂量输送技术的发展。随着治疗计划和剂量输送的复杂性增加，对多维定量剂量输送验证的需求不断增长。射线胶片已成为二维剂量分布测量的事实上的标准。随着诊所向电子成像方向发展，对射线照相胶片使用至关重要的胶片处理器正在被移除。最近引进了多点电子剂量计，用于剂量分布验证。虽然这些设备的使用是快速和方便的，但它们仅限于测量垂直于入射光束定向的单个平面，并且不能用于大多数几何体模，其使用对于治疗计划系统调试是至关重要的。除了测量维度之外，剂量计的一个重要操作特性是用户表征和监测剂量计响应的能力。多点电子剂量计可以做到这一点，但高分辨率的一次性剂量计（如射线照相或辐射变色胶片）则不行。我们建议开发一种新型的，可重复使用的，高分辨率的二维剂量计的有效原子序数（Z）接近水。该剂量计将是由分散在聚合物粘合剂中的低Z存储磷光体颗粒组成的存储磷光体板（SPP）。我们的第一个目标是开发一种制备低Z存储荧光粉的方法。我们的第二个目标是量化的剂量特性和优化的荧光粉生产过程中开发的目标1。我们的第三个目标是使用最先进的流延方法生产SPP原型。这些具体目标的成功完成将提供一个定量的二维剂量计，可用于现有的几何体模，并可以重复使用，使剂量测定特性可以确定和监测的物理学家。