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STORAGE PHOSPHOR FILM FOR RADIATION THERAPY DOSIMETRY

用于放射治疗剂量测定的存储荧光粉膜

基本信息

批准号：
8484213
负责人：
Harold Hui Li
金额：
$ 28.76万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8484213
关键词：
Benchmarking Characteristics Chemical Structure Chemistry Clinical Communities Complex Data Dependence Deposition Development Diagnostic radiologic examination Dose Electronics Europium Exhibits Film Hardness Head and neck structure Institution Intensity-Modulated Radiotherapy Measurement Microchemistry Modality Monitor Nature Physics Potassium Chloride Process Radiation Radiation Oncology Radiation Tolerance Radiation therapy Radiometry Reporting Research Resolution Sampling Shapes Signal Transduction Source System Techniques Testing Thick Time United States National Institutes of Health Vacuum Water Work X-Ray Film base detector dosimetry evaporation experience flexibility improved ionization irradiation luminescence novel particle prototype quality assurance research and development response simulation tool treatment planning two-dimensional vapor

项目摘要

Modern radiation therapy modalities, for example, intensity modulated radiation therapy (IMRT), are associated with highly conformal dose distributions with steep gradients. Commissioning of these modalities requires the use of multidimensional dosimeters which have been under intense research and development. A recent report from the Radiological Physics Center (RPC) revealed that roughly 30% of institutions failed to deliver a dose distribution to a head-and-neck phantom that agrees with their own treatment plan to within 7% or 4 mm. The RPC report provides strong evidence that IMRT implementation is prone to error and that improved quality assurance tools are required. The overarching hypothesis of this research is that a low-Z KCl:Eu2+ storage phosphor film (SPF) will provide the first 2D dosimeter capable of conducting benchmark dosimetry measurements, substantially improving the commissioning and quality assurance of radiation therapy treatment planning and delivery systems. Our first aim is to optimize KCl:Eu2+ storage phosphor particle composition and chemical structure to maximize radiation sensitivity, radiation hardness, response uniformity, and signal stability. Our second aim is to develop a process to fabricate an SPF by evaporating the optimized storage phosphor developed in aim 1 to a thickness on the order of one micron using physical vapor deposition onto a nearly water-equivalent substrate. Our third aim is to demonstrate that the SPF dosimeter developed in aim 2 will provide benchmark-quality dose distribution measurements and to demonstrate the flexibility of the SPF fabrication process by building planar and cylindrical dosimeters.

现代放射治疗方式，例如调强放射治疗（IMRT），是相关的

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Temporal signal stability of KCl:Eu(2+) storage phosphor dosimeters.

KCl:Eu(2) 存储荧光粉剂量计的时间信号稳定性。

DOI：
10.1118/1.4789482
发表时间：
2013
期刊：
Medical physics
影响因子：
3.8
作者：
Xiao,Zhiyan;Hansel,Rachael;Chen,Haijian;Du,Dongsu;Yang,Deshan;Li,HHarold
通讯作者：
Li,HHarold

The role of activator concentration and precipitate formation on optical and dosimetric properties of KCl:Eu(2+) storage phosphor detectors.

活化剂浓度和沉淀形成对 KCl:Eu(2) 存储荧光粉探测器的光学和剂量学特性的作用。

DOI：
10.1118/1.4817522
发表时间：
2013
期刊：
Medical physics
影响因子：
3.8
作者：
Hansel,RachaelA;Xiao,Zhiyan;Hu,Yanle;Green,Olga;Yang,Deshan;HaroldLi,H
通讯作者：
HaroldLi,H

The role of oxygen in the photostimulation luminescence process of europium doped potassium chloride.

氧在铕掺杂氯化钾光刺激发光过程中的作用。

DOI：
10.1016/j.radmeas.2015.03.013
发表时间：
2015
期刊：
Radiation measurements
影响因子：
2
作者：
Xiao,Zhiyan;Mazur,ThomasR;Driewer,JosephP;Li,HHarold
通讯作者：
Li,HHarold

Temperature dependence of the photostimulated luminescence in KCl:Eu2+

KCl:Eu2 中光激发光的温度依赖性

DOI：
10.1016/j.nimb.2013.09.031
发表时间：
2014
期刊：
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms
影响因子：
0
作者：
Xiao,Zhiyan;Hansel,Rachael;Zhang,Lei;Li,HHarold
通讯作者：
Li,HHarold

X ray storage performance of KCl:Eu(2+) with high cumulated dose.

高累积剂量KCl:Eu(2)的X射线存储性能。

DOI：
10.1016/j.nimb.2013.08.067
发表时间：
2014
期刊：
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms
影响因子：
0
作者：
Hansel,RachaelA;Xiao,Zhiyan;Zhang,Lei;Li,HHarold
通讯作者：
Li,HHarold