STORAGE PHOSPHOR FILM FOR RADIATION THERAPY DOSIMETRY

用于放射治疗剂量测定的存储荧光粉膜

• 批准号: 8484213
• 负责人: Harold Hui Li
• 金额: $ 28.76万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8484213
• 关键词: Benchmarking; Characteristics; Chemical Structure; Chemistry; Clinical; Communities; Complex; Data; Dependence; Deposition; Development; Diagnostic radiologic examination; Dose; Electronics; Europium; Exhibits; Film; Hardness; Head and neck structure; Institution; Intensity-Modulated Radiotherapy; Measurement; Microchemistry; Modality; Monitor; Nature; Physics; Potassium Chloride; Process; Radiation; Radiation Oncology; Radiation Tolerance; Radiation therapy; Radiometry; Reporting; Research; Resolution; Sampling; Shapes; Signal Transduction; Source; System; Techniques; Testing; Thick; Time; United States National Institutes of Health; Vacuum; Water; Work; X-Ray Film; base; detector; dosimetry; evaporation; experience; flexibility; improved; ionization; irradiation; luminescence; novel; particle; prototype; quality assurance; research and development; response; simulation; tool; treatment planning; two-dimensional; vapor

Modern radiation therapy modalities, for example, intensity modulated radiation therapy (IMRT), are associated with highly conformal dose distributions with steep gradients. Commissioning of these modalities requires the use of multidimensional dosimeters which have been under intense research and development. A recent report from the Radiological Physics Center (RPC) revealed that roughly 30% of institutions failed to deliver a dose distribution to a head-and-neck phantom that agrees with their own treatment plan to within 7% or 4 mm. The RPC report provides strong evidence that IMRT implementation is prone to error and that improved quality assurance tools are required. The overarching hypothesis of this research is that a low-Z KCl:Eu2+ storage phosphor film (SPF) will provide the first 2D dosimeter capable of conducting benchmark dosimetry measurements, substantially improving the commissioning and quality assurance of radiation therapy treatment planning and delivery systems. Our first aim is to optimize KCl:Eu2+ storage phosphor particle composition and chemical structure to maximize radiation sensitivity, radiation hardness, response uniformity, and signal stability. Our second aim is to develop a process to fabricate an SPF by evaporating the optimized storage phosphor developed in aim 1 to a thickness on the order of one micron using physical vapor deposition onto a nearly water-equivalent substrate. Our third aim is to demonstrate that the SPF dosimeter developed in aim 2 will provide benchmark-quality dose distribution measurements and to demonstrate the flexibility of the SPF fabrication process by building planar and cylindrical dosimeters.

现代放射疗法方式，例如强度调制辐射疗法（IMRT）是相关的 具有高度的保形剂量分布，具有陡峭的梯度。这些方式的调试需要 使用多维剂量计的使用，这些剂量计已受到强烈的研究和开发。最近的报告 来自放射物理中心（RPC）的发现，大约30％的机构未能提供剂量 分配给头颈幻影，与他们自己的治疗计划一致，达到7％或4毫米以内。这 RPC报告提供了有力的证据，表明IMRT实施容易出错，并且质量提高了 需要保证工具。这项研究的总体假设是低Z KCl：EU2+存储 磷光膜（SPF）将提供能够进行基准剂量法的第一个2D剂量计 测量，大大改善了放射疗法的调试和质量保证 治疗计划和交付系统。我们的第一个目的是优化KCL：EU2+储存磷光粒子 组成和化学结构，以最大化辐射敏感性，辐射硬度，响应均匀性， 和信号稳定性。我们的第二个目的是开发一个过程来通过蒸发优化来制造SPF 用物理蒸气沉积在AIM 1中开发到AIM 1的储存磷光 上几乎水等效的底物。我们的第三个目的是证明SPF剂量计在 AIM 2将提供基准质量剂量分布测量，并证明 通过建筑平面和圆柱剂量计的SPF制造过程。

项目成果

Temporal signal stability of KCl:Eu(2+) storage phosphor dosimeters.

KCl:Eu(2) 存储荧光粉剂量计的时间信号稳定性。

• DOI: 10.1118/1.4789482
• 发表时间: 2013
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Xiao,Zhiyan;Hansel,Rachael;Chen,Haijian;Du,Dongsu;Yang,Deshan;Li,HHarold
• 通讯作者: Li,HHarold

The role of activator concentration and precipitate formation on optical and dosimetric properties of KCl:Eu(2+) storage phosphor detectors.

活化剂浓度和沉淀形成对 KCl:Eu(2) 存储荧光粉探测器的光学和剂量学特性的作用。

• DOI: 10.1118/1.4817522
• 发表时间: 2013
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Hansel,RachaelA;Xiao,Zhiyan;Hu,Yanle;Green,Olga;Yang,Deshan;HaroldLi,H
• 通讯作者: HaroldLi,H

The role of oxygen in the photostimulation luminescence process of europium doped potassium chloride.

氧在铕掺杂氯化钾光刺激发光过程中的作用。

• DOI: 10.1016/j.radmeas.2015.03.013
• 发表时间: 2015
• 期刊: Radiation measurements
• 影响因子: 2
• 作者: Xiao,Zhiyan;Mazur,ThomasR;Driewer,JosephP;Li,HHarold
• 通讯作者: Li,HHarold

Temperature dependence of the photostimulated luminescence in KCl:Eu2+

KCl:Eu2 中光激发光的温度依赖性

• DOI: 10.1016/j.nimb.2013.09.031
• 发表时间: 2014
• 期刊: Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms
• 作者: Xiao,Zhiyan;Hansel,Rachael;Zhang,Lei;Li,HHarold
• 通讯作者: Li,HHarold

X ray storage performance of KCl:Eu(2+) with high cumulated dose.

高累积剂量KCl:Eu(2)的X射线存储性能。

• DOI: 10.1016/j.nimb.2013.08.067
• 发表时间: 2014
• 期刊: Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms
• 作者: Hansel,RachaelA;Xiao,Zhiyan;Zhang,Lei;Li,HHarold
• 通讯作者: Li,HHarold