STORAGE PHOSPHOR FILM FOR RADIATION THERAPY DOSIMETRY

用于放射治疗剂量测定的存储荧光粉膜

• 批准号: 8096736
• 负责人: Harold Hui Li
• 金额: $ 30.59万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8096736
• 关键词: Benchmarking; Characteristics; Chemical Structure; Chemistry; Clinical; Communities; Complex; Data; Dependence; Deposition; Development; Diagnostic radiologic examination; Dose; Electronics; Europium; Exhibits; Film; Hardness; Head and neck structure; Institution; Intensity-Modulated Radiotherapy; Measurement; Microchemistry; Modality; Monitor; Nature; Physics; Potassium Chloride; Process; Radiation; Radiation Oncology; Radiation Tolerance; Radiation therapy; Radiometry; Reporting; Research; Resolution; Sampling; Shapes; Signal Transduction; Source; System; Techniques; Testing; Thick; Time; United States National Institutes of Health; Vacuum; Water; Work; X-Ray Film; base; detector; dosimetry; evaporation; experience; flexibility; improved; ionization; irradiation; luminescence; novel; particle; prototype; public health relevance; quality assurance; research and development; response; simulation; tool; treatment planning; two-dimensional; vapor

DESCRIPTION (provided by applicant): Modern radiation therapy modalities, for example, intensity modulated radiation therapy (IMRT), are associated with highly conformal dose distributions with steep gradients. Commissioning of these modalities requires the use of multidimensional dosimeters which have been under intense research and development. A recent report from the Radiological Physics Center (RPC) revealed that roughly 30% of institutions failed to deliver a dose distribution to a head-and-neck phantom that agrees with their own treatment plan to within 7% or 4 mm. The RPC report provides strong evidence that IMRT implementation is prone to error and that improved quality assurance tools are required. The overarching hypothesis of this research is that a low-Z KCl:Eu2+ storage phosphor film (SPF) will provide the first 2D dosimeter capable of conducting benchmark dosimetry measurements, substantially improving the commissioning and quality assurance of radiation therapy treatment planning and delivery systems. Our first aim is to optimize KCl:Eu2+ storage phosphor particle composition and chemical structure to maximize radiation sensitivity, radiation hardness, response uniformity, and signal stability. Our second aim is to develop a process to fabricate an SPF by evaporating the optimized storage phosphor developed in aim 1 to a thickness on the order of one micron using physical vapor deposition onto a nearly water-equivalent substrate. Our third aim is to demonstrate that the SPF dosimeter developed in aim 2 will provide benchmark-quality dose distribution measurements and to demonstrate the flexibility of the SPF fabrication process by building planar and cylindrical dosimeters. PUBLIC HEALTH RELEVANCE: The successful completion of this research will provide the radiation oncology community with the first two-dimensional dosimeter prototype capable of acquiring benchmark dose measurements. This will be critical for the safe and efficient utilization of modern, complex radiation delivery techniques such as IMRT.

描述（由申请人提供）：例如，现代放射疗法方式，例如强度调制辐射疗法（IMRT），与具有陡峭梯度的高度保形剂量分布有关。对这些方式进行调试需要使用多维剂量计，而多维剂量计在强烈的研究和开发下。放射物理中心（RPC）的最新报告显示，大约30％的机构未能将剂量分配给头颈幻影，该幻影与他们自己的治疗计划一致，以在7％或4毫米内。 RPC报告提供了有力的证据，表明IMRT实施容易出错，并且需要改善质量保证工具。这项研究的总体假设是，低Z KCl：EU2+储存磷光膜（SPF）将提供能够进行基准测量测量的第一个2D剂量计，从而实质上改善了放射治疗治疗计划和递送系统的调试和质量保证。我们的第一个目的是优化KCL：EU2+储存磷光颗粒组成和化学结构，以最大程度地提高辐射灵敏度，辐射硬度，响应均匀性和信号稳定性。我们的第二个目的是通过将AIM 1中开发的优化储存磷光蒸发到一个微米的厚度上，使用物理蒸气沉积到几乎水等效的底物上，从而开发出一种制造SPF的过程。我们的第三个目的是证明AIM 2中开发的SPF剂量计将提供基准质量的剂量分布测量，并通过构建平面和圆柱剂量计来证明SPF制造过程的灵活性。 公共卫生相关性：这项研究的成功完成将为辐射肿瘤学界提供第一个二维剂量计原型，能够获得基准剂量测量。这对于现代，复杂的辐射输送技术（例如IMRT）的安全有效利用至关重要。