All-fiber, wavelength tunable femtosecond sources for biomedical applications

适用于生物医学应用的全光纤、波长可调飞秒源

• 批准号: 7345671
• 负责人: CHRIS XU
• 金额: $ 19.58万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7345671
• 关键词: Academia; Biomedical Research; Class; Clinical; Collaborations; Communication; Couples; Development; Diagnostic; Environment; Feedback; Fiber; Fiber Optics; Foundations; Frequencies; Future Generations; Goals; Grant; Industry; Lasers; Manufacturer Name; Medical; Methodology; Operative Surgical Procedures; Optics; Output; Partner in relationship; Physiologic pulse; Printing; Pulse taking; Range; Rate; Research; Research Infrastructure; Research Personnel; Safety; Science; Silicon Dioxide; Solid; Source; System; Techniques; Technology; Telecommunications; Testing; Time; Tissues; Universities; base; concept; cost; design; emission spectroscopy; foot; innovation; instrumentation; novel; optical fiber; programs; research study

DESCRIPTION (provided by applicant): The goal of this research program is to develop a novel optical fiber that will enable wavelength tunable, all-fiber, energetic femtosecond sources, and then demonstrate the value of the proposed laser system for biomedical applications. The innovation of the proposed femtosecond sources is based on a new class of optical fiber that was recently demonstrated, where, for the first time, a large anomalous dispersion was achieved at wavelengths below 1300 nm in an all-silica fiber. The proposed research concentrates on the development of a novel higher order mode fiber for wavelength tuning based on the concept of soliton self-frequency shift. Leveraging the highly mature and integrated techniques that have been developed for the telecommunications industry, we aim to create two "telecom grade" femtosecond sources that are truly robust and turn-key, and tailored specifically for biomedical research and clinical diagnostics. This research program involves close collaboration between Cornell University (Dr. Xu) and fiber manufacturer OFS-Fitel (Dr. Ramachandran). The industry-academia collaboration proposed in this program strongly couples biomedical optics and the fiber-optic communication industry, creating great synergies between two seemingly divergent fields and providing new opportunities for innovation in biomedical research. The ultimate aim of this exploratory instrumentation grant is to establish a novel methodology for wavelength tunable, energetic femtosecond fiber lasers for biomedical applications.The proposed program, if successfully completed, leads to a novel, wavelength tunable, femtosecond fiber laser that will have a broad impact on biomedical applications of ultrafast technologies. There are significant practical advantages offered by the all-fiber configuration, such as compact foot print, robust operation, and operational safety in a clinical environment. The successful completion of this research program will make femtosecond sources truly widely accessible to biologists and medical researchers and practitioner.

描述（由申请人提供）：本研究计划的目标是开发一种新型光纤，该光纤将实现波长可调谐，全光纤，高能飞秒光源，然后证明拟议的激光系统在生物医学应用中的价值。所提出的飞秒光源的创新是基于最近展示的一类新的光纤，其中第一次在全石英光纤中在低于1300 nm的波长处实现了大的异常色散。该研究的重点是开发一种基于孤立子自频移概念的新型高次模波长调谐光纤。利用为电信行业开发的高度成熟和集成的技术，我们的目标是创建两个“电信级”飞秒源，它们真正强大和交钥匙，并专门为生物医学研究和临床诊断量身定制。这项研究计划涉及康奈尔大学（徐博士）和光纤制造商OFS-Fitel（Ramachandran博士）之间的密切合作。该计划中提出的产学合作将生物医学光学和光纤通信行业紧密结合在一起，在两个看似不同的领域之间创造了巨大的协同效应，并为生物医学研究的创新提供了新的机会。该项目的最终目标是为生物医学应用建立一种新的波长可调谐的高能飞秒光纤激光器的方法，如果该项目成功完成，将产生一种新的波长可调谐的飞秒光纤激光器，对超快技术的生物医学应用产生广泛的影响。全光纤配置具有显著的实用优势，例如紧凑的占地面积、稳健的操作以及在临床环境中的操作安全性。这项研究计划的成功完成将使生物学家和医学研究人员和从业者真正广泛地获得飞秒源。