ON THE ROLE OF THE GINS COMPLEX IN REPLICATION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。GINS复合物由至少四种不同的多肽组成，在真核生物的DNA复制中起着重要但尚未确定的作用。在这项工作中，我们使用了一系列在实验室中开发的生化技术，结合酵母的遗传操作来阐明这种复合物的功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The GINS complex, consisting of at least four different polypeptides, plays an important but as yet undefined role in DNA replication of eukaryotes. In this work, we are using a series of biochemical techniques developed in the laboratory in conjunction with genetic manipulation of yeast to throw light on the function of this complex.