ON THE ROLE OF THE GINS COMPLEX IN REPLICATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 GINS复合体由至少四种不同的多肽组成，在真核生物的DNA复制中发挥着重要但尚未确定的作用。在这项工作中，我们使用了实验室开发的一系列生化技术，并结合酵母的遗传操作来揭示这种复合体的功能。描述这项工作的手稿已经提交。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The GINS complex, consisting of at least four different polypeptides, plays an important but as yet undefined role in DNA replication of eukaryotes. In this work, we are using a series of biochemical techniques developed in the laboratory in conjunction with genetic manipulation of yeast to throw light on the function of this complex. A manuscript describing this work has been submitted.