EXERCISE TRAINING ON FRAILTY IN COMMUNITY DWELLING OLDER ADULTS

针对社区老年人衰弱的运动训练

• 批准号: 7355159
• 负责人: ELLEN F BINDER
• 金额: $ 0.59万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355159
• 关键词: EXERCISE; TRAINING; FRAILTY; COMMUNITY; DWELLING

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Progressive resistance training (PRT) has been shown to increase muscle strength and fat free mass (FFM) in the elderly. Limited information is available regarding the effects of PRT on lean and fat mass in frail elders. Methods: Ninety-three community-dwelling sedentary men and women, 78 years and older with physical frailty, defined using standardized objective criteria were enrolled in a 9-month trial of exercise training. Participants were randomly assigned to a control group (CTL) that performed low intensity home exercise program, or an exercise-training program (ET) that included 3 months of supervised PRT. Results: After completion of 3 months of PRT, ET subjects had greater improvements than CTL in maximal voluntary force production for knee extension (mean D +5.3 ¿13 ft/lb vs. +1.1¿11 ft/lb, p=0.05) measured using isokinetic dynamometry. Total body FFM (measured using dual energy x-ray absorptiometry, DEXA) increased in the ET group, but not the CTL group (mean D+0.84 ¿1.4 kg vs. +0.01¿1.5 kg, p0.005). Total, trunk, intra-abdominal, and subcutaneous fat mass (measured using DEXA and 1H-magnetic resonance imaging) did not change in response to PRT. Conclusions: Three months of PRT induced improvements in maximal voluntary thigh muscle strength and whole body FFM in frail, community-dwelling elderly women and men. The supervised exercise program may not be sufficient to reduce whole body or intra-abdominal fat area in this population.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。背景：渐进式阻力训练（PRT）已被证明可以增加老年人的肌肉力量和无脂量（FFM）。关于PRT对体弱老年人瘦脂肪量影响的信息有限。方法：93名78岁及以上身体虚弱的社区居住久坐男性和女性，采用标准化的客观标准进行了9个月的运动训练试验。参与者被随机分配到对照组（CTL），进行低强度的家庭锻炼计划，或运动训练计划（ET），其中包括3个月的监督PRT。结果：在完成3个月的PRT后，ET受试者在膝关节伸展的最大自主力产生方面比CTL有更大的改善（平均D +5.3¿13 ft/lb vs +1.1¿11 ft/lb, p=0.05）。全身FFM（使用双能x线吸收仪，DEXA测量）在ET组增加，但CTL组没有（平均D+0.84 ~ 1.4 kg vs +0.01 ~ 1.5 kg, p0.005）。总脂肪量、躯干脂肪量、腹内脂肪量和皮下脂肪量（使用DEXA和1h磁共振成像测量）在PRT治疗后没有变化。结论：三个月的PRT可改善体弱的社区老年女性和男性的最大随意大腿肌力和全身FFM。在监督下的锻炼计划可能不足以减少整个身体或腹腔内的脂肪面积。